scholarly journals Intrinsic hippocampal functional connectivity underlying rigid memory in children and adolescents with autism spectrum disorder: A case–control study

Autism ◽  
2021 ◽  
pp. 136236132110040
Author(s):  
Teruo Hashimoto ◽  
Susumu Yokota ◽  
Yutaka Matsuzaki ◽  
Ryuta Kawashima
Keyword(s):  
Autism Spectrum Disorder ◽  
High Functioning Autism ◽  
Later Life ◽  
Memory Systems ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
Relational Memory ◽  
Typically Developing ◽  
Memory Processing ◽  
Delayed Recognition

Atypical learning and memory in early life can promote atypical behaviors in later life. Less relational learning and inflexible retrieval in childhood may enhance restricted and repeated behaviors in patients with autism spectrum disorder. The purpose of this study was to elucidate the mechanisms of atypical memory in children with autism spectrum disorder. We conducted picture–name pair learning and delayed-recognition tests with two groups: one group with high-functioning autism spectrum disorder children (aged 7–16, n = 41) and one group with typically developing children ( n = 82) that matched the first group’s age, sex, and IQ. We assessed correlations between successful recognition scores and seed-to-whole-brain resting-state functional connectivity. Although both learning and retrieval performances were comparable between the two groups, we observed slightly lower category learning and significantly fewer memory gains in the autism spectrum disorder group than in the typically developing group. The right canonical anterior hippocampal network was involved in successful memory in youths with typically developing, while other memory systems may be involved in successful memory in youths with autism spectrum disorder. Context-independent and less relational memory processing may be associated with fewer memory gains in autism spectrum disorder. These atypical memory characteristics in autism spectrum disorder may accentuate their inflexible behaviors in some situations. Lay abstract Atypical learning and memory in early life can promote atypical behaviors in later life. Specifically, less relational learning and inflexible retrieval in childhood may enhance restricted and repeated behaviors in patients with autism spectrum disorder. The purpose of this study was to elucidate the mechanisms of atypical memory in children with autism spectrum disorder. We conducted picture–name pair learning and delayed-recognition tests with two groups of youths: one group with high-functioning autism spectrum disorder children (aged 7–16, n = 41) and one group with typically developing children ( n = 82) that matched the first group’s age, sex, and full-scale IQ. We examined correlations between successful recognition scores and neural connectivity during resting in the magnetic resonance imaging scanner without thinking about anything. Although both learning and retrieval performances were comparable between the two groups, we observed significantly fewer memory gains in the autism spectrum disorder group than in the typically developing group. The memory network was involved in successful memory retrieval in youths with typically developing, while the other memory systems that do not depend to a great degree on networks may be involved in successful memory in youths with autism spectrum disorder. Context-independent and less relational memory processing may be associated with fewer memory gains in autism spectrum disorder. In other words, autism spectrum disorder youths might benefit from non-relational memory. These atypical memory characteristics in autism spectrum disorder may exaggerate their inflexible behaviors in some situations, or—vice versa—their atypical behaviors may result in rigid and less connected memories.

‘Just trying to talk to people … It’s the hardest’: Perspectives of adolescents with high-functioning autism spectrum disorder on their social communication skills

2018 ◽  
Vol 34 (3) ◽  
pp. 319-334 ◽  
Author(s):  
Rachel Kelly ◽  
Mary-Pat O’Malley ◽  
Stanislava Antonijevic
Keyword(s):  
Autism Spectrum Disorder ◽  
Communication Skills ◽  
Social Communication ◽  
High Functioning Autism ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
Typically Developing ◽  
High Functioning ◽  
Social Communication Skills ◽  
Increased Risk

Difficulty with social communication is the most pervasive difficulty experienced by individuals with high-functioning autism spectrum disorder (HF-ASD). Communication difficulties are often magnified in adolescence as social demands become more intricate. This puts adolescents with HF-ASD at increased risk of social isolation and depression, as they have difficulty developing positive social identity. Yet, there is a dearth of literature addressing the communication issues of this population and even fewer studies including the voice of adolescents with HF-ASD themselves. This study aimed to (1) explore the perspectives of adolescents with HF-ASD as to their social communication skills, (2) explore what (if any) difficulties they perceive themselves as having when talking with their peers, (3) explore if they would like help with social communication skills and (4) determine what kind of help they think may be useful to them and establish if they already use self-initiated strategies. This study was qualitative in nature, using thematic analysis to analyse data collected from 10 semi-structured interviews with 5 adolescents with HF-ASD. Qualitative research underpins the idea that one must understand the significance and explanation that people give to situations, experiences, their own actions and to the actions of others, for one to comprehend human behaviours and actions. A qualitative design allowed us to gain the most in depth insight into how adolescents with HF-ASD understand and perceive their experiences. Three themes emerged revealing the participants’ perceptions of their difficulties communicating, challenging feelings that they experience about communication, and their perspectives about the support for developing communication skills. The participants indicated a need for support to aid their desire to improve communication skills and interactions with typically developing peers. In educational settings, adolescents with HF-ASD may benefit from a peer mentor system to give them opportunities to practice social communication skills with typically developing peers and to encourage inclusion amongst their classmates.

scholarly journals The pausative pattern of speakers with and without high-functioning autism spectrum disorder from long silences

Pragmatics ◽  
2015 ◽  
Vol 25 (2) ◽  
pp. 229-249
Author(s):  
Francisco J. Rodríguez Muñoz
Keyword(s):  
Autism Spectrum Disorder ◽  
High Functioning Autism ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
Typically Developing ◽  
High Functioning ◽  
Positional Analysis

This study aims to accomplish the functional and positional analysis of long silences – single, double or triple – in the oral productions of 20 speakers with high-functioning autism spectrum disorder and 20 typically-developing speakers. Thus, a pausative pattern, which combines different quantitative measures, is proposed for speakers with this disorder. Different comparisons showed homogeneity in the relative average between the word quantity and the number of long pauses in oral interactions of both groups. Finally, the excess of long internal shared pauses that are produced by speakers with high-functioning autism due to comprehension problems or lack of attention during dialogue is significant.

Profiles of Autonomic Activity in Autism Spectrum Disorder with and without Anxiety

2019 ◽  
Author(s):  
Valentina Parma ◽  
Nicola Cellini ◽  
Lisa Guy ◽  
Alana McVey ◽  
Keiran Rump ◽  
...  
Keyword(s):  
Autism Spectrum Disorder ◽  
Anxiety Disorders ◽  
Physiological Activity ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
Parasympathetic Activity ◽  
Typically Developing ◽  
Physiological Profile ◽  
School Aged Children ◽  
Advance Research

Objective: Anxiety disorders are common among youth with autism spectrum disorder (ASD). Both anxiety and ASD are associated with differences in physiological activity. To date, few studies have investigated the physiological profile of youth with ASD and even fewer have systematically assessed how the co-occurrence of anxiety disorders and ASD modulates resting physiological activity.Method: The aim of the present study was to evaluate sympathetic and parasympathetic activity at rest in 75 school-aged children and adolescents with ASD, with (ASD+Anxiety = 22, 6F) and without co-occurring anxiety (ASD Alone =15, 6F) and to compare their physiological profile with that of matched typically developing controls (TDC) with (Anxiety Alone = 16, 6F) and without co-occurring anxiety disorders (TDC = 22, 8F).Results: Results indicated reduced sympathetic and parasympathetic activity at rest in ASD as compared to TDC youth without anxiety. The ASD+Anxiety and Anxiety Alone groups showed different sympathetic, but similar parasympathetic, activity. Correlational, multivariate, and regression analyses indicated that the four groups differed among several physiological and subjective measures.Conclusion: These findings suggest that ASD and anxiety are associated with distinct profiles of autonomic nervous system activity that cannot be reduced to either the sympathetic or parasympathetic branch alone. An autonomic profile-based approach is more likely to advance research, diagnosis, and treatment of ASD and anxiety than unidimensional, single-modality approaches.

Attention Deficit Hyperactivity Disorder in Autism Spectrum Disorder

2020 ◽  
pp. 158-176
Author(s):  
Karen Bearss ◽  
Aaron J. Kaat
Keyword(s):  
Autism Spectrum Disorder ◽  
Attention Deficit Hyperactivity Disorder ◽  
Attention Deficit ◽  
Autism Spectrum ◽  
Developmental Trajectory ◽  
Spectrum Disorder ◽  
Adhd Symptoms ◽  
Functional Impairments ◽  
Hyperactivity Disorder ◽  
Delayed Recognition

This chapter will review the available evidence on individuals with co-occurring diagnoses of autism spectrum disorder (ASD) and attention deficit hyperactivity disorder (ADHD). This chapter contends that children diagnosed with both disorders (ASD+ADHD) are a subset of the ASD population that is at risk for delayed recognition of their ASD diagnosis, poor treatment response, and poorer functional outcomes compared to those with ASD without ADHD. Specifically, the chapter highlights the best estimates of the prevalence of the comorbidity, the developmental trajectory of people with co-occurring ASD and ADHD, how ADHD symptoms change across development, overlapping genetic and neurobiological risk factors, psychometrics of ADHD diagnostic instruments in an ASD population, neuropsychological and functional impairments associated with co-occurring ASD and ADHD, and the current state of evidence-based treatment for both ASD and ADHD symptoms. Finally, the chapter discusses fruitful avenues of research for improving understanding of this high-risk comorbidity so that mechanism-to-treatment pathways for ADHD in children with ASD can be better developed.

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