Angiotensin II type 2 receptor gene polymorphisms in cardiovascular disease

Introduction: Hypertension is a complex disease in which a significant interaction between genetic and environmental factors takes place. The renin–angiotensin system plays an important role regulating blood pressure to maintain homeostasis and vascular tone. In the present work, the role of angiotensin II type 1-receptor (AGTR1) gene polymorphisms as susceptibility markers for hypertension was evaluated. Materials and methods: Five polymorphisms in the AGTR1 gene were genotyped by 5′ exonuclease TaqMan genotyping assays in 239 hypertensive and 371 non-hypertensive individuals. Results: A similar distribution of rs275651, rs275652, rs275653, and rs5183 polymorphisms was observed in both studied groups. Different distribution of rs5182 genotypes was observed between the studied groups ( p = 0.016). According to the co-dominant model, individuals with rs5182 CC genotype have a 1.83-fold increased risk of developing hypertension ( p = 0.009). Polymorphisms were distributed in two blocks: block 1 included the rs275651, rs275652, and rs275653 polymorphisms, whereas block 2 included the rs5183 and rs5182 polymorphisms. Individuals with hypertension showed increased frequency of ‘ CA’ haplotype of block 2 when compared to non-hypertensive individuals ( p = 0.015, odds ratio = 1.33). Conclusion: The results suggest that the rs5182 gene polymorphism could be involved in the risk of developing hypertension in Mexican individuals.

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Angiotensinogen and Angiotensin II Type 1 Receptor Gene Polymorphisms and Changes in Repolarization Parameters in Elderly Chinese: A 4-Year Follow-up Study

The Kaohsiung Journal of Medical Sciences ◽

10.1016/s1607-551x(08)70138-4 ◽

2008 ◽

Vol 24 (3) ◽

pp. 111-119

Author(s):

Ya-Ting Lee ◽

Herng-Chia Chiu ◽

Ho-Ming Su ◽

Wen-Chol Voon ◽

Tsung-Hsien Lin ◽

...

Keyword(s):

Angiotensin Ii ◽

Gene Polymorphisms ◽

Receptor Gene ◽

Follow Up Study ◽

Elderly Chinese ◽

Receptor Gene Polymorphisms

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Association of Vitamin D deficiency and Vitamin D Receptor Gene Polymorphisms with Type 2 diabetes mellitus Saudi patients

African Health Sciences ◽

10.4314/ahs.v19i4.2 ◽

1970 ◽

Vol 19 (4) ◽

pp. 2812-2818

Author(s):

Ayman S Al-Hazmi

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Vitamin D ◽

Vitamin D Receptor ◽

Gene Polymorphisms ◽

Receptor Gene ◽

Vitamin D Receptor Gene ◽

Receptor Gene Polymorphisms ◽

25 Oh Vitamin D

Background: Type 2 diabetes mellitus (T2DM) is a global problem. Association of multiple genes in T2DM becomes a hot point recently. This study was aimed to evaluate association of vitamin D receptor gene polymorphisms with susceptibility to T2DM. Subjects and methods: One hundred T2DM Saudi male patients were included in this study and one hundred healthy Saudi men were used as control. For each individual, fasting blood glucose, cholesterol, HDL-C, LDL-C, HbA1c, insulin and 25-(OH) vitamin D were measured. In addition, Apal, BsmI and TaqI genotypes were performed for each subject. Data was analyzed by SPSS version 16, using Spearman's rho and ANOVA tests. Results: There was significant inverse correlation between 25-(OH) vitamin D level and T2DM (p<0.01). HbA1c was inversely correlated with 25-(OH) vitamin D level (P<0.05). Genotype study showed that tt of TaqI genotype was higher in T2DM group compared with control group (p<0.05). Moreover, tt genotype has higher HbA1c than both TT and Tt genotypes (p<0.05). Conclusion: An association was confirmed between TaqI genotypes and T2DM but there is no correlation between BsmI, ApaI and T2DM. In addition, HbA1c is positively correlated with tt genotype of TaqI.Keywords: Vitamin D receptor, diabetes type 2, polymorphism.

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