Pure Red Cell Aplasia and Myelofibrosis in B-cell Neoplasm

2005 ◽  
Vol 33 (4) ◽  
pp. 460-466 ◽  
Author(s):  
Y Hatta ◽  
Y Kura ◽  
T Yano ◽  
H Ushiyama ◽  
M Sugitani ◽  
...  
Keyword(s):  
Bone Marrow ◽  
B Cells ◽  
B Cell ◽  
Bone Marrow Aspiration ◽  
Pure Red Cell Aplasia ◽  
Severe Anaemia ◽  
Erythroid Cell ◽  
Red Cell ◽  
Red Cell Aplasia ◽  
Cell Neoplasm

We describe an unusual case of B-cell neoplasm accompanied by pure red cell aplasia (PRCA) and myelofibrosis in a 67-year-old male presenting with severe anaemia. A few unclassified, myeloperoxidase-negative blastoid cells were seen on bone marrow aspiration, and erythroid cell hypoplasia and myelofibrosis on bone marrow biopsy. An autoimmune PRCA was suspected, as serum CH50, C3 and C4 levels were consistently low. Ciclosporin was effective in treating the anaemia, but anaemia returned when the drug was discontinued. Thirteen months later, the patient was admitted with pleural effusion and ascites that contained monoclonal CD19+ CD20+ immature blast cells with a complex karyotype, thought to be neoplastic B-cells. The unclassified blastoid cells seen earlier may therefore have been from the same origin. The patient deteriorated rapidly and died. Only one case of non-Hodgkin's lymphoma with PRCA and myelofibrosis has been reported previously. We discuss the possibility that dysregulated T-cells induced by neoplastic B-cells may have given rise to concomitant PRCA and myelofibrosis.

PURE RED CELL APLASIA : A CASE REPORT

2021 ◽  
pp. 55-56
Author(s):  
G Srivani ◽  
D Roja Aishwarya ◽  
P. V. S. Kiran
Keyword(s):  
Bone Marrow ◽  
Bone Marrow Failure ◽  
Bone Marrow Aspiration ◽  
Oral Prednisolone ◽  
Pure Red Cell Aplasia ◽  
Red Cell ◽  
Red Cell Aplasia ◽  
Normocytic Normochromic Anemia ◽  
Pure Cell ◽  
Normochromic Anemia

Pure cell aplasia is a rare bone marrow failure that affects erythroid lineage characterized by normocytic normochromic anemia with reticulocytopenia in the peripheral blood and absent or infrequent erythroblasts in the bone marrow. It can be congenital or acquired. Acquired can be primary when no cause is identied or secondary-due to underlying or associated pathology. Herein we report a case of a 28 year old female with Primary Acquired Pure Red cell aplasia. The patient presented with severe anemia (Hb-1.9gm%) and low reticulocyte count 0.1%. Bone marrow aspiration shows normocellular marrow with Decreased erythropoiesis with M:E ratio of 20:1..Patient was started on oral prednisolone and improvement was seen and the patient became transfusion independent.

Pure red cell aplasia associated with B cell lymphoma: Demonstration of bone marrow colony inhibition by serum immunoglobulin

1990 ◽  
Vol 14 (3) ◽  
pp. 279-286 ◽  
Author(s):  
Roxanne Alter ◽  
Shantaram S. Joshi ◽  
Joseph D. Verdirame ◽  
Dennis D. Weisenburger
Keyword(s):  
Bone Marrow ◽  
B Cell ◽  
Cell Lymphoma ◽  
B Cell Lymphoma ◽  
Pure Red Cell Aplasia ◽  
Serum Immunoglobulin ◽  
Red Cell ◽  
Red Cell Aplasia

Anemia: Production Defects Generally Associated with Marrow Aplasia or Replacement

2017 ◽  
Author(s):  
Nancy Berliner ◽  
John M Gansner
Keyword(s):  
Bone Marrow ◽  
Differential Diagnosis ◽  
Aplastic Anemia ◽  
Blood Smear ◽  
Pure Red Cell Aplasia ◽  
Red Cell ◽  
Normal Bone Marrow ◽  
Normal Bone ◽  
Red Cell Aplasia

This review focuses on anemia resulting from production defects generally associated with marrow aplasia or replacement. The definition, epidemiology, etiology, pathogenesis, diagnosis, differential diagnosis, management, complications, and prognosis of the following production defects are discussed: Acquired aplastic anemia and acquired pure red cell aplasia. Figures depict a leukoerythroblastic blood smear, a biopsy comparing normal bone marrow and bone marrow showing almost complete aplasia, and a marrow smear. A table lists the causes of aplastic anemia. This review contains 3 figures; 1 table; 108 references.

scholarly journals Pure red cell aplasia caused by Parvo B19 virus in a kidney transplant recipient

2012 ◽  
Vol 52 (186) ◽  
Author(s):  
A Baral ◽  
B Poudel ◽  
R K Agrawal ◽  
R Hada ◽  
S Gurung
Keyword(s):  
Bone Marrow ◽  
Transplant Recipient ◽  
Intravenous Immunoglobulin ◽  
Kidney Transplant ◽  
Parvovirus B19 ◽  
Kidney Transplant Recipient ◽  
Pure Red Cell Aplasia ◽  
Red Cell ◽  
Erythroid Progenitor ◽  
Red Cell Aplasia

Parvo B19 is a single stranded DNA virus, which typically has affi nity for erythroid progenitor cells in the bone marrow and produces a severe form of anemia known as pure red cell aplasia. This condition is particularly worse in immunocompromised individuals. We herein report a young Nepali male who developed severe and persistent anaemia after kidney transplantation while being on immunosuppressive therapy. His bone marrow examination revealed morphological changes of pure red cell aplasia, caused by parvovirus B19. The IgM antibody against the virus was positive and the virus was detected by polymerase chain reaction in the blood. He was managed with intravenous immunoglobulin. He responded well to the treatment and has normal hemoglobin levels three months post treatment. To the best of our knowledge, this is the fi rst such case report from Nepal. Keywords: Intravenous immunoglobulin, kidney transplant recipient, Parvovirus B19, pure red cell aplasia.

scholarly journals Carbamazepine-Induced Pure Red Cell Aplasia

2018 ◽  
Vol 05 (01) ◽  
pp. 050-052 ◽  
Author(s):  
C. Mansoor ◽  
Laksmi Priya
Keyword(s):  
Bone Marrow ◽  
Rare Disease ◽  
Pure Red Cell Aplasia ◽  
Normocytic Anemia ◽  
Red Cell ◽  
Normal Bone Marrow ◽  
Hematologic Disorders ◽  
Normal Bone ◽  
Red Cell Aplasia ◽  
Carbamazepine Therapy

AbstractAntiepileptic therapy is associated with various hematologic disorders. Pure red cell aplasia (PRCA) is a rare disease that may be congenital or acquired. Severe normocytic anemia, reticulocytopenia, and absence of erythroblasts from an otherwise normal bone marrow should raise the suspicion of PRCA. A 32-year-old unmarried woman was admitted with fatigue for 4 months. She had been on carbamazepine therapy for 4 years (200 mg twice daily) for seizure disorder. On evaluation, she was diagnosed to have PRCA secondary to carbamazepine. We describe a patient with carbamazepine-induced PRCA that improved after discontinuation of the drug.

scholarly journals Pure red cell aplasia due to parvovirus following treatment with CHOP and rituximab for B-cell lymphoma*

2002 ◽  
Vol 119 (1) ◽  
pp. 125-127 ◽  
Author(s):  
Kevin W. Song ◽  
Peter Mollee ◽  
Bruce Patterson ◽  
William Brien ◽  
Michael Crump
Keyword(s):  
B Cell ◽  
Cell Lymphoma ◽  
B Cell Lymphoma ◽  
Pure Red Cell Aplasia ◽  
Red Cell ◽  
Red Cell Aplasia
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