Multidimensional Phase I Dose Ranging Trials for Stroke Recovery Interventions: Key Challenges and How to Address Them

2021 ◽  
pp. 154596832110193
Author(s):  
Emily J. Dalton ◽  
Leonid Churilov ◽  
Natasha A. Lannin ◽  
Dale Corbett ◽  
Bruce C. V. Campbell ◽  
...  
Keyword(s):  
Decision Support ◽  
Phase I ◽  
Early Phase ◽  
Phase I Trial ◽  
Systematic Approach ◽  
Decision Support Tool ◽  
Maximum Tolerated Dose ◽  
Stroke Recovery ◽  
Support Tool ◽  
Dose Ranging

Despite an increase in the amount of published stroke recovery research, interventions have failed to markedly affect the trajectory of recovery poststroke. We argue that early-phase research to systematically investigate dose is an important contributor to advance the science underpinning stroke recovery. In this article, we aim to ( a) define the problem of insufficient use of a systematic approach to early-phase, multidimensional dose articulation research and ( b) propose a solution that applies this approach to design a multidimensional phase I trial to identify the maximum tolerated dose (MTD). We put forward a design template as a decision support tool to increase knowledge of how to develop a phase I dose-ranging trial for nonpharmaceutical stroke recovery interventions. This solution has the potential to advance the development of efficacious stroke recovery interventions, which include activity-based rehabilitation interventions.

A Decision Support Tool for Evaluating Big Data Investment in Transport: Empirical evidence from European use cases of NOESIS project

2020 ◽  
Author(s):  
Christos Katrakazas ◽  
Natalia Sobrino ◽  
Ilias Trochidis ◽  
Jose Manuel Vassallo ◽  
Stratos Arampatzis ◽  
...  
Keyword(s):  
Big Data ◽  
Decision Support ◽  
Empirical Evidence ◽  
Decision Support Tool ◽  
Use Cases ◽  
Support Tool

A Decision Support Tool for Wastewater Catchment Management

2007 ◽  
Vol 2 (2) ◽  
Author(s):  
S.E. Walters ◽  
D. Savic ◽  
R.J. Hocking
Keyword(s):  
Decision Support ◽  
Asset Management ◽  
Capital Investment ◽  
Management Strategies ◽  
Sewage Treatment ◽  
Decision Support Tool ◽  
Catchment Management ◽  
Clean Water ◽  
Support Tool ◽  
South West

The water industry over the years has primarily focussed on upgrading and investing in clean water provision. However, as research into the science and management of clean water services has progressed rapidly, wastewater provision and services has been slower. Focus, though, is now shifting within Industry and Research into wastewater services. The water regulator, Ofwat, for England and Wales demands the Sewerage Undertakers demonstrate efficient management of wastewater systems in order to obtain funding for Capital Investment projects. South West Water, a Water Service Provider and Sewerage Undertaker located in the South West of England, identified a need gap in their asset management strategies for wastewater catchments. This paper will introduce the production of a Decision Support Tool, DST, to help SWW proactively manage their Wastewater Catchments, examining Sewage Treatment Works, Pumping Stations and Networks. The paper will discuss some concepts within the DST, its production, testing and a brief case study. The DST provides a framework for prioritising catchments to optimise investment choices and actions. The Tool ranks catchments utilising Compromise Programming, CP, as well as AHP Pair-wise comparisons for preference weights. The DST incorporates Asset models, a Whole life Costing Module, as well as a Decay and Intervention Module.

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