To effectively evaluate the level of economic security of water resources (WES) in China and analyze its influencing factors, a comprehensive evaluation model of WES and a regression analysis model of influencing factors are established based on the panel data of 30 provinces in China from 2011 to 2017. It is found that, first, WES in China presents a fluctuating upward trend. Second, different regions have different economic security levels for their water resources in China, among which WES in the central region is the highest. Third, there is a U-shaped correlation between economic development and WES, and the population, pollution control level, technological innovation have negative impacts on WES. Moreover, this study also finds that with upgrades to the industrial structure and level of human capital, there will be improvements to WES. However, the external coefficient and the investment scale of fixed assets have a negative impact on the economic security of water resources. This is helpful to utilize the water resources, and improve the water resources safety management.