Prevalence of cerebral vein thrombosis among patients with spontaneous intracranial hypotension

2021 ◽  
pp. 159101992110659
Author(s):  
M Oien ◽  
JK Cutsforth-Gregory ◽  
I Garza ◽  
NR Kissoon ◽  
CM Carr ◽  
...  
Keyword(s):  
Intracranial Hypotension ◽  
Sinus Thrombosis ◽  
Spontaneous Intracranial Hypotension ◽  
Rare Condition ◽  
Cerebral Venous Sinus Thrombosis ◽  
Cerebral Vein ◽  
Imaging Findings ◽  
Arteriovenous Fistulas ◽  
Vein Thrombosis ◽  
Lobar Hemorrhage

Background and purpose Cerebral venous sinus thrombosis (CVST) is a rare condition but an important complication of spontaneous intracranial hypotension (SIH). We reviewed our experience of patients with SIH and assessed for the presence of CVST. Methods We reviewed the medical records and imaging studies from our tertiary referral institution, assessing patients with clinically suspected SIH as well as imaging findings of intracranial hypotension. All relevant brain MRIs were reviewed for the presence of brain sag, pachymeningeal enhancement, and CVST. Results Among 563 patients with a clinical diagnosis of SIH, 431 (76%) demonstrated brain sag. In the overall patient cohort, a total of 5 patients had CVST (0.9%) and all 5 of these patients demonstrated findings of brain sag. Of the patients with CVST, 3 had significant complications, including dural arteriovenous fistulas (2 patients) and lobar hemorrhage with seizure (1 patient). Conclusion SIH is a risk factor for the development of CVST. In our review of 563 patients with clinical and/or imaging findings of SIH, 0.9% of patients were diagnosed with CVST and 3 of these patients (60%) had additional severe complications.

scholarly journals Cerebral venous thrombosis following spontaneous intracranial hypotension diagnosed by craniotomy: A case report and diagnostic pitfalls

2021 ◽  
Vol 12 ◽  
pp. 367
Author(s):  
Shigeomi Yokoya ◽  
Hideki Oka ◽  
Akihiko Hino
Keyword(s):  
Intracranial Hypotension ◽  
Sinus Thrombosis ◽  
Fluid Pressure ◽  
Spontaneous Intracranial Hypotension ◽  
Dural Sinus ◽  
Cerebral Vein ◽  
Imaging Findings ◽  
Cortical Vein ◽  
Vein Thrombosis ◽  
Cortical Vein Thrombosis

Background: Cerebral vein and dural sinus thrombosis (CVT) is a rare but important complication of spontaneous intracranial hypotension (SIH). The diagnosis is difficult in cases lacking typical symptoms and typical imaging findings. Case Description: A 29-year-old male patient with a seizure attack was admitted to our hospital. Based on the head imaging findings, we misdiagnosed the patient with primary cerebral parenchymal lesion and performed an open biopsy. However, during the procedure, the patient was diagnosed with low cerebrospinal fluid pressure and cerebral cortical vein thrombosis. Conclusion: Thus, CVT due to SIH should be considered as a probable cause of secondary parenchymal lesions.

scholarly journals A case of thrombocytopenia and multiple thromboses after vaccination with ChAdOx1 nCoV-19 against SARS-CoV-2

2021 ◽  
Vol 5 (12) ◽  
pp. 2569-2574
Author(s):  
Anne Louise Tølbøll Sørensen ◽  
Magalie Rolland ◽  
Jacob Hartmann ◽  
Zitta Barrella Harboe ◽  
Casper Roed ◽  
...  
Keyword(s):  
Sinus Thrombosis ◽  
Cerebral Venous Sinus Thrombosis ◽  
Cerebral Vein ◽  
Platelet Factor ◽  
Oral Contraceptive Pills ◽  
Vein Thrombosis ◽  
Contraceptive Pills ◽  
Prothrombin Mutation ◽  
Vectored Vaccine ◽  
Clinical Awareness

Recently, reports of severe thromboses, thrombocytopenia, and hemorrhage in persons vaccinated with the chimpanzee adenovirus-vectored vaccine (ChAdOx1 nCoV-19, AZD1222, Vaxzevria; Oxford/AstraZeneca) against severe acute respiratory syndrome coronavirus 2 have emerged. We describe an otherwise healthy 30-year-old woman who developed thrombocytopenia, ecchymosis, portal vein thrombosis, and cerebral venous sinus thrombosis the second week after she received the ChAdOx1 nCoV-19 vaccine. Extensive diagnostic workup for thrombosis predispositions showed heterozygosity for the prothrombin mutation, but no evidence of myeloproliferative neoplasia or infectious or autoimmune diseases. Her only temporary risk factor was long-term use of oral contraceptive pills (OCPs). Although both the prothrombin mutation and use of OCPs predispose to portal and cerebral vein thrombosis, the occurrence of multiple thromboses within a short time and the associated pattern of thrombocytopenia and consumption coagulopathy are highly unusual. A maximum 4T heparin-induced thrombocytopenia (HIT) score and a positive immunoassay for anti-platelet factor 4/heparin antibodies identified autoimmune HIT as a potential pathogenic mechanism. Although causality has not been established, our case emphasizes the importance of clinical awareness. Further studies of this potentially new clinical entity have suggested that it should be regarded as a vaccine-induced immune thrombotic thrombocytopenia.

Headache Due to Spontaneous Intracranial Hypotension and Subsequent Cerebral Vein Thrombosis

2012 ◽  
Vol 52 (10) ◽  
pp. 1592-1596 ◽  
Author(s):  
Paolo Costa ◽  
Elisabetta Del Zotto ◽  
Alessia Giossi ◽  
Irene Volonghi ◽  
Loris Poli ◽  
...  
Keyword(s):  
Intracranial Hypotension ◽  
Spontaneous Intracranial Hypotension ◽  
Cerebral Vein ◽  
Cerebral Vein Thrombosis ◽  
Vein Thrombosis

scholarly journals Diagnosis and Management of Lemierre’s Syndrome Presented with Multifocal Pneumonia and Cerebral Venous Sinus Thrombosis

2020 ◽  
Vol 2020 ◽  
pp. 1-5
Author(s):  
Yasar Sattar ◽  
Ammu Thampi Susheela ◽  
Bibek Karki ◽  
Adnan Liaqat ◽  
Waqas Ullah ◽  
...  
Keyword(s):  
Sinus Thrombosis ◽  
Fusobacterium Nucleatum ◽  
Cerebral Venous Sinus Thrombosis ◽  
Venous Sinus ◽  
Jugular Vein Thrombosis ◽  
Lemierre Syndrome ◽  
Venous Sinus Thrombosis ◽  
Vein Thrombosis ◽  
Cerebral Sinus Venous Thrombosis ◽  
Magnetic Resonance Imaging Mri

A 27-year-old female patient initially presented with fever, myalgia, sore throat that progressed to multifocal pneumonia, and cerebral sinus venous thrombosis. A combination of upper respiratory symptoms with tooth infection, positive blood culture for Fusobacterium nucleatum, computed tomography (CT) chest finding of multifocal pneumonia, and magnetic resonance imaging (MRI) finding of internal jugular vein thrombosis (IJVT) and cerebral venous sinus thrombosis (CVST) suggested Lemierre syndrome. The patient was managed with fluids, antibiotics, and anticoagulants. The patient survived and discharged from the hospital. The patient’s symptoms improved at 2 months of follow-up.

scholarly journals A Lady with Systemic Lupus Erythematosus Complicated with Central Venous Sinus Thrombosis: A Case Report

2020 ◽  
Vol 20 (01) ◽  
pp. 42-46
Author(s):  
Alexandra Hoi Yan Ng ◽  
Daniel Kam Hung Ng
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Antiphospholipid Antibodies ◽  
Sinus Thrombosis ◽  
Rare Condition ◽  
Cerebral Venous Sinus Thrombosis ◽  
Venous Sinus ◽  
Systemic Lupus ◽  
Venous Sinus Thrombosis ◽  
Increased Risk

Systemic lupus erythematosus (SLE) is associated with an increased risk of venous thromboses and cerebrovascular diseases. Herein, we discuss the case of a young 38-year-old Asian lady who was presented with cerebral venous sinus thrombosis (CVST) shortly after she was diagnosed with SLE. She developed headache, right hemiparesis and sustained an episode of seizure on the first presentation. CVST was diagnosed with plain computed tomography (CT) of the brain and CT venogram. With prompt administration of anticoagulation and immunosuppressant treatment for SLE, she had an excellent neurological recovery. There are many different risk factors for developing CVST in SLE patients. It has been reported in literature that CVST is usually associated with antiphospholipid antibodies but only around 40% of them would have positive antiphospholipid antibodies indicating that there are also other mechanisms contributing to the process [1]. As CVST in SLE is a rare condition, no standardized treatment strategy has been delineated. The main cornerstone of treatment would be anticoagulation and appropriate treatment for SLE as these patients are commonly associated with underlying active SLE. With timely management, the prognosis for CVST in SLE patients is generally favourable.

Fatal cerebral venous sinus thrombosis as major complication of metastatic cervical mass: computed tomography and magnetic resonance findings

2000 ◽  
Vol 114 (10) ◽  
pp. 798-801 ◽  
Author(s):  
Maria F. López-Peláez ◽  
José M. Millán ◽  
Joaquin de Vergas
Keyword(s):  
Sinus Thrombosis ◽  
Major Complication ◽  
Cerebral Venous Sinus Thrombosis ◽  
Venous Sinus ◽  
Jugular Vein Thrombosis ◽  
Cervical Mass ◽  
Venous Sinus Thrombosis ◽  
Vein Thrombosis ◽  
Sagittal Sinus ◽  
Common Causes

Cerebral venous sinus thrombosis is an uncommon but potentially lethal condition, with mortality between 5.5–30 per cent. It was previously associated with infections of the orbit, mastoid or face, but, after the advent of antibiotics, the most common causes include neoplasms, dehydration, oral contraceptives, coagulopathies, collagen diseases, and pregnancy and the puerperium. We report a case of fatal cerebral venous sinus thrombosis in a 68-year-old patient with a metastatic cervical mass, who developed internal jugular vein thrombosis that progressed cranially to transverse and sagittal sinus thrombosis.

Atypical venous thromboses in myeloproliferative neoplasias

Phlebologie ◽  
2015 ◽  
Vol 44 (06) ◽  
pp. 324-329
Author(s):  
C. Dicke ◽  
A. Frölich ◽  
K. Holstein ◽  
C. Bokemeyer ◽  
F. Langer
Keyword(s):  
Platelet Count ◽  
Deep Vein Thrombosis ◽  
Sinus Thrombosis ◽  
Jak2 V617f ◽  
Cerebral Venous Sinus Thrombosis ◽  
Venous Sinus Thrombosis ◽  
Vein Thrombosis ◽  
Thrombotic Complications ◽  
Deep Vein ◽  
Venous Thromboses

SummaryWe describe two patients who developed an extensive catheter-related upper extremity deep vein thrombosis and a cerebral venous sinus thrombosis, respectively. Both thrombotic complications occurred in the presence of an elevated platelet count. Subsequent detection of the JAK2 V617F and MPL mutations led to the diagnosis of a myeloproliferative neoplasia.

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