scholarly journals Efficient Synthesis of the Insect Elicitor Volicitin and Biologically Active Analogs

2007 ◽  
Vol 2 (10) ◽  
pp. 1934578X0700201
Author(s):  
Venkat Krishnamachari ◽  
Xitao Xie ◽  
Shifang Zhu ◽  
Han-Xun Wei ◽  
Paul W Paré
Keyword(s):  
Biologically Active ◽  
Efficient Synthesis ◽  
Coupling Procedure ◽  
Beet Army Worm ◽  
Army Worm

An improved and efficient copper (I) mediated coupling procedure was used to synthesize N-(17-hydroxylinolenoyl)-L-glutamine (volicitin), a chemical elicitor from the herbivore pest beet army worm, and its biologically active analogs.

scholarly journals Cover Picture: Biologically Active Compounds through Catalysis: Efficient Synthesis ofN-(Heteroarylcarbonyl)-N′-(arylalkyl)piperazines (Chem. Eur. J. 3/2004)

2004 ◽  
Vol 10 (3) ◽  
pp. 563-563
Author(s):  
Kamal Kumar ◽  
Dirk Michalik ◽  
Ivette Garcia Castro ◽  
Annegret Tillack ◽  
Alexander Zapf ◽  
...  
Keyword(s):  
Biologically Active Compounds ◽  
Biologically Active ◽  
Efficient Synthesis ◽  
Active Compounds

ChemInform Abstract: An Efficient Synthesis of Phenanthro-Fused Thiazoles by a Non-Phenolic Oxidative Coupling Procedure of 4,5-Diarylthiazoles.

ChemInform ◽  
2010 ◽  
Vol 30 (39) ◽  
pp. no-no
Author(s):  
I. Moreno ◽  
I. Tellitu ◽  
R. SanMartin ◽  
D. Badia ◽  
L. Carrillo ◽  
...  
Keyword(s):  
Oxidative Coupling ◽  
Efficient Synthesis ◽  
Coupling Procedure

Biologically Active Compounds through Catalysis: Efficient Synthesis ofN-(Heteroarylcarbonyl)-N′-(arylalkyl)piperazines

2004 ◽  
Vol 10 (3) ◽  
pp. 746-757 ◽  
Author(s):  
Kamal Kumar ◽  
Dirk Michalik ◽  
Ivette Garcia Castro ◽  
Annegret Tillack ◽  
Alexander Zapf ◽  
...  
Keyword(s):  
Biologically Active Compounds ◽  
Biologically Active ◽  
Efficient Synthesis ◽  
Active Compounds

scholarly journals An Efficient Synthesis of Tetrodotoxin

2021 ◽  
Author(s):  
David Konrad ◽  
Peter Ruehmann ◽  
Hiroyasu Ando ◽  
Belinda Hetzler ◽  
Bryan Matsuura ◽  
...  
Keyword(s):  
Tertiary Amine ◽  
Stereoselective Synthesis ◽  
Primary Alcohol ◽  
Biologically Active ◽  
Dipolar Cycloaddition ◽  
Protecting Group ◽  
Efficient Synthesis ◽  
Ready Access ◽  
Biologically Active Derivatives ◽  
Glucose Derivative

Tetrodotoxin (TTX) is an indispensable probe in neuroscience, a biosynthetic and ecological enigma, and one of the most celebrated targets of synthetic chemistry. Here, we present a stereoselective synthesis of TTX that proceeds in 22 steps starting from a readily available glucose derivative. The central cyclohexane ring of TTX and its α-tertiary amine moiety was established via the intramolecular 1,3-dipolar cycloaddition of a nitrile oxide, followed by alkynyl addition to the resultant isoxazoline. After some carefully chosen protecting group manipulations, a ruthenium-catalyzed hydroxylactonization set the stage for the formation of its dioxa-adamantane core. Installation of the guanidine, oxidation of a primary alcohol, and late-stage epimerization of the resultant aldehyde gave a mixture of TTX and anhydro TTX. Our synthesis represents one of the most effective of TTX reported to date and could give ready access to biologically active derivatives.

SYNERGISM OF PYRETHROIDS BY PIPERONYL BUTOXIDE AND MGK-264 AGAINST HELIOTHIS VIRESCENS, SPODOPTERA EXIGUA, AND SPODOPTERA FRUGIPERDA (LEPIDOPTERA: NOCTUIDAE)1

1988 ◽  
Vol 23 (3) ◽  
pp. 229-233
Author(s):  
J. A. Joyce ◽  
R. J. Ottens ◽  
G. A. Herzog ◽  
M. H. Bass
Keyword(s):  
Spodoptera Frugiperda ◽  
Heliothis Virescens ◽  
Spodoptera Exigua ◽  
Synergistic Effects ◽  
Fall Armyworm ◽  
Piperonyl Butoxide ◽  
Tobacco Budworm ◽  
Lepidoptera Noctuidae ◽  
Beet Army Worm ◽  
Army Worm

Laboratory cultures of field-collected larval tobacco budworm, Heliothis virescens (F.), beet army worm, Spodoptera exigua (Hübner), and fall armyworm, S. frugiperda (J. E. Smith) were bioassayed for response to three pyrethroids in combination with piperonyl butoxide (PBO), or MGK-264. The greatest synergistic effects were seen in S. exigua which also displayed the greatest tolerance to pyrethroids without synergists. The highest SR50 (synergist ratio) value for S. exigua was 22.1 with fenvalerate-PBO mixed in a ratio of 1:5, the highest for S. frugiperda was 4.6 with fenvalerate-MGK-264 1:5, and the highest for H. virescens was 1.3 with permethrin-MGK-264 1:5 or with fenvalerate-PBO 1:5.

Triflic acid-catalyzed metal-free synthesis of (E)-2-cyanoacrylamides and 3-substituted azetidine-2,4-diones

2018 ◽  
Vol 42 (8) ◽  
pp. 6433-6440 ◽  
Author(s):  
Bapurao D. Rupanwar ◽  
Santosh S. Chavan ◽  
Anil M. Shelke ◽  
Gurunath M. Suryavanshi
Keyword(s):  
Biologically Active ◽  
Efficient Synthesis ◽  
Triflic Acid ◽  
Metal Free ◽  
Highly Efficient ◽  
Acid Catalyzed

A TfOH-catalyzed highly efficient synthesis of biologically active (E)-2-cyanoacrylamides and 3-substituted azetidine-2,4-diones has been reported with 64–94% yields under metal-free conditions.

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