A New Carbazole Alkaloid from Murraya koenigii Spreng (Rutaceae)

A new carbazole alkaloid (kurryam) oxygenated at the 4-position, hitherto unknown among carbazole alkaloids, has been isolated from the seeds of an Indian medicinal plant, Murraya koenigii (Rutaceae). The structure has been established as 4-hydroxy-(2′,2′,3)-trimethyl-(6,7)-dimethoxy pyranocarbazole from extensive 2D NMR spectral studies. In addition, two known carbazole alkaloids, (2′,2′,3)-trimethyl 6-methoxy pyranocarbazole and (2′,2′,3)-trimethyl 6-hydroxy pyranocarbazole were isolated from the seeds of the same plant, of which (2′,2′,3)-trimethyl 6-methoxy pyranocarbazole exhibited significant antidiarrhoeal activity, as also did the new compound.

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Mumunine - A New Carbazole Alkaloid from Murraya koenigii (Linn.) Spreng

Journal of Scientific Research ◽

10.3329/jsr.v12i4.45499 ◽

2020 ◽

Vol 12 (4) ◽

pp. 665-672

Author(s):

M. Chakraborty

Keyword(s):

Data Analysis ◽

Spectral Data ◽

Structure Elucidation ◽

2D Nmr ◽

Rich Source ◽

Murraya Koenigii ◽

Spectral Data Analysis ◽

Carbazole Alkaloids

The plant Murraya koenigii, commonly known as curry leaf tree is a rich source of carbazole alkaloids. A number of monomeric as well as dimeric carbazoles with C13, C18 and C23 skeleton have been isolated from the plant. In my present work, a new carbazole alkaloid, designated as mumunine, was isolated from the bark of Murraya koenigii (Linn) Spreng, along with a known carbazole alkaloid, viz. mahanimbine. The structure of the new alkaloid 1 was elucidated on the basis of 1D and 2D NMR spectral data analysis. In this paper, the isolation and structure elucidation of the new compound will be discussed in detail.

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Dammarane triterpenoid saponins from Bacopa monnieri

Canadian Journal of Chemistry ◽

10.1139/v09-111 ◽

2009 ◽

Vol 87 (9) ◽

pp. 1230-1234 ◽

Cited By ~ 10

Author(s):

Pamita Bhandari ◽

Neeraj Kumar ◽

Bikram Singh ◽

Inderjeet Kaur

Keyword(s):

Medicinal Plant ◽

2D Nmr ◽

Bacopa Monnieri ◽

Spectroscopic Methods ◽

Triterpenoid Saponins ◽

Enhancing Effect ◽

Indian Medicinal Plant ◽

Aerial Parts ◽

Memory Enhancer ◽

Memory Enhancing

Bacopa monnieri is a well-known Ayurvedic Indian medicinal plant traditionally used as a memory enhancer. Its memory-enhancing effect is mainly attributed to dammarane triterpenoid saponins. In the present study, two new dammarane-type triterpenoid saponins, bacopaside-XI (1) and bacopaside-XII (2), together with known compounds, bacopaside IV, bacopaside V, and apigenin, were isolated from the aerial parts of the B. monnieri . The structures of the new saponins were elucidated as 3-O-[α-L-arabinofuranosyl(1→3)]-6-O-sulfonyl-β-D-glucopyranosyl pseudojujubogenin (1) and 3-O-{β-D-glucopyranosyl(1→3)[α-L-arabinofuranosyl(1→2)]-β-D-glucopyranosyl}-20-O-α-L-arabinopyranosyl pseudojujubogenin (2) on the basis of extensive investigations of 1D and 2D NMR (HMQC and HMBC), ESI-QTOF-MS/MS spectroscopic methods, and chemical evidences.

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CYCLIC MONOTERPENOID PYRANOCARBAZOLE ALKALOIDS FROM THE BARK OF Murraya koenigii (L.) SPRENG

Jurnal Teknologi ◽

10.11113/jt.v77.5990 ◽

2015 ◽

Vol 77 (2) ◽

Author(s):

Kartini Ahmad ◽

Siow-Ping Tan ◽

Hazrina Hazni ◽

Mohd Azlan Nafiah

Keyword(s):

Mass Spectrometry ◽

2D Nmr ◽

Hexane Extract ◽

Phytochemical Analysis ◽

Murraya Koenigii ◽

Chromatographic Techniques ◽

Carbazole Alkaloids

Murraya koenigii, locally known as "kari" tree, was selected for the phytochemical analysis. The extraction and isolation of the carbazole alkaloids from its n-hexane extract of the bark was carried out by using various chromatographic techniques. Three cyclic monoterpenoid pyranocarbazole alkaloids namely, murrayazolinol, murrayakoeninol and bicyclomahanimbine, were isolated. Their structures were determined on the basis of 1D-, 2D-NMR, IR, UV and mass spectrometry, and by comparison with the data from literature.

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Murrayakoeninol- A New Carbazole Alkaloid from Murraya Koenigii (Linn) Spreng

Natural Product Communications ◽

10.1177/1934578x0900400309 ◽

2009 ◽

Vol 4 (3) ◽

pp. 1934578X0900400 ◽

Cited By ~ 6

Author(s):

Mumu Chakraborty ◽

Sudipta Saha ◽

Sibabrata Mukhapadhyay

Keyword(s):

Spectral Analysis ◽

Chemical Reactions ◽

2D Nmr ◽

Murraya Koenigii ◽

Carbazole Alkaloids

A new carbazole alkaloid, designated as murrayakoeninol, was isolated from the leaves of Murraya koenigii (Linn) Spreng, along with four known carbazole alkaloids, viz. mahanimbine, koenimbine, O-methylmurrayamine-A and murrayazolinine and one from the bark viz. girinimbine. The structure of the new alkaloid 1 was elucidated on the basis of 2D NMR spectral analysis and chemical reactions.

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Indian Ayurvedic Plant Identification Using Multi-Organ Image Analytics: Creation of Image Dataset of Indian Medicinal Plant Organs

SSRN Electronic Journal ◽

10.2139/ssrn.3563074 ◽

2020 ◽

Author(s):

Meera Kansara ◽

Ajay Parikh

Keyword(s):

Medicinal Plant ◽

Plant Identification ◽

Plant Organs ◽

Indian Medicinal Plant ◽

Image Dataset

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Flavonoids from Tephrosia Calophylla

Natural Product Communications ◽

10.1177/1934578x0900400114 ◽

2009 ◽

Vol 4 (1) ◽

pp. 1934578X0900400

Author(s):

Ramireddy V. Narahari Reddy ◽

Shaik I. Khalivulla ◽

Bandi A.K. Reddy ◽

Mopuru V. Bhaskar Reddy ◽

Duvvuru Gunasekar ◽

...

Keyword(s):

2D Nmr ◽

Spectral Studies

Two new flavanones, (2S)-5-hydroxy-7,4′-di-O-(γ,γ-dimethylallyl)flavanone (1) and 6-hydroxy- E-3-(2,5-dimethoxy-benzylidine)-2′,5′-dimethoxyflavanone (2), together with three known compounds, tephrowatsin C, afrormosin and kaempferol 3-O-β-D-glucopyranoside were isolated from the roots of Tephrosia calophylla. The structures of 1 and 2 were established by extensive 2D NMR spectral studies.

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