scholarly journals Formulation Study of Tea Tree Oil Patches

2009 ◽  
Vol 4 (1) ◽  
pp. 1934578X0900400
Author(s):  
Paola Minghetti ◽  
Antonella Casiraghi ◽  
Francesco Cilurzo ◽  
Veniero Gambaro ◽  
Luisa Montanari
Keyword(s):  
Skin Penetration ◽  
Critical Issue ◽  
Skin Permeability ◽  
Silicone Resin ◽  
Tea Tree Oil ◽  
Melaleuca Alternifolia ◽  
Tea Tree ◽  
Eudragit E100 ◽  
Main Component ◽  
Franz Diffusion Cells

The antimicrobial, antifungal and anti-inflammatory properties of tea tree oil (TTO), the essential oil of Melaleuca alternifolia are well documented. In order to optimize its therapeutic activity, TTO patches were designed. The aim of this work was the formulation of monolayer patches containing TTO. Moreover, the performance of oleic acid (OA) as a skin penetration enhancer in patches was evaluated. Terpinen-4-ol (T4OL), the main component of TTO, was the marker used to evaluate TTO skin permeability. The permeation study was performed through human epidermis by using Franz diffusion cells. Patches were prepared by using methacrylic copolymers, Eudragit E100 (EuE100) or Eudragit NE (EuNE), and a silicone resin, BioPSA7-4602 (Bio-PSA). TTO and OA contents were fixed at 10% w/w and 3% w/w, respectively. The patches were prepared by a casting method and characterised in terms of T4OL content and skin permeability. All the selected polymers were suitable as the main component of the patch matrix. Since the main critical issue in the use of TTO is related to its toxicity after absorption, the local administration of TTO can take advantage of the use of patches based on EuE100 because of the high retained amount and the low permeation of T4OL. In this matrix, OA slightly increased the T4OL retained amount, improving the efficacy and safety of TTO patches.

scholarly journals Terpinen-4-ol, The Main Component of Melaleuca Alternifolia (Tea Tree) Oil Inhibits the In Vitro Growth of Human Melanoma Cells

2004 ◽  
Vol 122 (2) ◽  
pp. 349-360 ◽  
Author(s):  
Annarica Calcabrini ◽  
Annarita Stringaro ◽  
Laura Toccacieli ◽  
Stefania Meschini ◽  
Manuela Marra ◽  
...  
Keyword(s):  
Melanoma Cells ◽  
Human Melanoma ◽  
In Vitro Growth ◽  
Tea Tree Oil ◽  
Melaleuca Alternifolia ◽  
Tea Tree ◽  
Human Melanoma Cells ◽  
Main Component

scholarly journals The Essential Oil of Melaleuca alternifolia (Tea Tree Oil) and Its Main Component, Terpinen-4-ol Protect Mice from Experimental Oral Candidiasis

2012 ◽  
Vol 35 (6) ◽  
pp. 861-865 ◽  
Author(s):  
Kentaro Ninomiya ◽  
Naho Maruyama ◽  
Shigeharu Inoue ◽  
Hiroko Ishibashi ◽  
Toshio Takizawa ◽  
...  
Keyword(s):  
Essential Oil ◽  
Oral Candidiasis ◽  
Tea Tree Oil ◽  
Melaleuca Alternifolia ◽  
Tea Tree ◽  
Main Component

Addition of tea tree oil (Melaleuca alternifolia) in diet minimize biochemical disturbances in silver catfish Rhamdia quelen exposed to the antiparasitic amitraz

Aquaculture ◽  
2021 ◽  
pp. 736954
Author(s):  
Tamires R. dos Reis ◽  
Matheus D. Baldissera ◽  
Carine F. Souza ◽  
Bernardo Baldisserotto ◽  
Julia Corá Segat ◽  
...  
Keyword(s):  
Tea Tree Oil ◽  
Melaleuca Alternifolia ◽  
Tea Tree ◽  
Silver Catfish ◽  
Rhamdia Quelen

Reproductive biology of Melaleuca alternifolia (Myrtaceae) 1. Floral biology

2010 ◽  
Vol 58 (5) ◽  
pp. 373 ◽  
Author(s):  
L. Baskorowati ◽  
M. W. Moncur ◽  
J. C. Doran ◽  
P. J. Kanowski
Keyword(s):  
Reproductive Biology ◽  
Floral Biology ◽  
Morphological Development ◽  
Tea Tree Oil ◽  
Melaleuca Alternifolia ◽  
Tea Tree ◽  
Viable Seeds ◽  
Individual Trees ◽  
Days After Anthesis ◽  
Flowering Intensity

Melaleuca alternifolia (Maiden & Betche) Cheel is commercially important as the source of essential oil for the Australian tea tree-oil industry. Information on reproductive biology of M. alternifolia is important to the Australian breeding program directed at improving the quality and quantity of tea tree oil. Flowering in three geographically separated sites – two planted seed orchards and one managed natural population, all in NSW – was observed in the present study, with supporting data obtained from glasshouse-grown plants in Canberra. The majority of the work was conducted from 2004 to 2007, although the study also drew on some prior observations. M. alternifolia has spikes of flowers that open acropetally over a 6-day period. No strong separation of male and female phases was found in any individual flower; pollen was shed by 1.4 days after anthesis and the stigma reached peak receptivity 3–5 days after anthesis. Dichogamy and acropetal floral development may lead to geitonogamy. Flowering occurred during the months of October–November, with the peak in November, and was synchronous across all three sites. Flowering intensity and success in producing capsules appeared to be associated with total spring rainfall. Initiation of flowering in M. alternifolia appears to be correlated with daylength, or an environmental parameter closely correlated with daylength. Flowering intensity varied considerably among the years surveyed, sites and families, and appears to be promoted by a period of winter minimum temperatures below 5°C. In M. alternifolia, the morphological development of buds, flowers and fruit leading to the development of mature seed takes place over a period 16–18 months from flowering. M. alternifolia differed significantly in the number of viable seeds per capsule from individual trees, from 26 ± 3.8 to 57 ± 3.8 germinants.

scholarly journals Emprego do óleo de Melaleuca alternifolia Cheel (Myrtaceae) na odontologia: perspectivas quanto à utilização como antimicrobiano alternativo às doenças infecciosas de origem bucal

2011 ◽  
Vol 13 (4) ◽  
pp. 492-499 ◽  
Author(s):  
A.C.M. Oliveira ◽  
A. Fontana ◽  
T.C. Negrini ◽  
M.N.M. Nogueira ◽  
T.B.L. Bedran ◽  
...  
Keyword(s):  
Tea Tree Oil ◽  
Melaleuca Alternifolia ◽  
Tea Tree

O interesse por medicamentos alternativos, principalmente daqueles provenientes de extratos naturais, tem aumentado nas últimas décadas. A Melaleuca alternifolia é um arbusto pertencente ao gênero Melaleuca, popularmente conhecida como "árvore de chá", cujo principal produto é o óleo essencial (TTO - tea tree oil), de grande importância medicinal por possuir comprovada ação bactericida e antifúngica contra diversos patógenos humanos. Em virtude da atividade terapêutica em diversas especialidades médicas, o TTO passou a ser empregado na área odontológica. Esta revisão de literatura foi realizada com o objetivo de discutir os ensaios já realizados com o TTO contra microrganismos relacionados à doença cárie, doença periodontal e problemas pulpares. O óleo de Melaleuca tem demonstrado boa ação antibacteriana in vitro contra microrganismos bucais, porém, pesquisas envolvendo o estudo do mecanismo de ação sobre as células microbianas ou estudos in vivo ainda são escassos e precisam ser realizados, já que esse produto pode ser útil na odontologia, seja na manutenção química da higiene ou prevenção de doenças bucais.

scholarly journals Azelaic acid and Melaleuca alternifolia essential oil co-loaded vesicular carrier for combinational therapy of acne

2021 ◽  
Author(s):  
Alpna Bisht ◽  
Chetna Hemrajani ◽  
Navneet Upadhyay ◽  
Prakriti Nidhi ◽  
Rajan Rolta ◽  
...  
Keyword(s):  
Azelaic Acid ◽  
Acne Vulgaris ◽  
Wistar Rat ◽  
Work Of Adhesion ◽  
Tea Tree Oil ◽  
Rat Skin ◽  
Melaleuca Alternifolia ◽  
Plastic Properties ◽  
Tea Tree ◽  
Retention Characteristics

Aim: Azelaic acid (AzA), a comedolytic, antibacterial, anti-inflammatory anti-melanogenic agent, prescribed against acne vulgaris is safe on skin. Its combination with another widely used anti-acne agent, tea tree oil (EO) whose delivery is limited by volatility, instability and lipophilicity constraints was attempted. Method: Solvent injection was used to prepare AzA-EO integrated ethosomes. Result: Ethosomes were transformed into carbopol hydrogel, which exhibited pseudo-plastic properties with appreciable firmness, work of shear, stickiness and work of adhesion. The hydrogel showed better permeation and retention characteristics vis-a-vis commercial formulation (AzidermTM), when evaluated in Wistar rat skin. Further, ethosome hydrogel composite was better tolerated with no side effects. Conclusion: The findings suggests that the aforementioned strategy could be a potential treatment used for acne management.

Synergism and postantibiotic effect of tobramycin and Melaleuca alternifolia (tea tree) oil against Staphylococcus aureus and Escherichia coli

Phytomedicine ◽  
2010 ◽  
Vol 17 (5) ◽  
pp. 317-322 ◽  
Author(s):  
Manuela D’Arrigo ◽  
Giovanna Ginestra ◽  
Giuseppina Mandalari ◽  
P.M. Furneri ◽  
G. Bisignano
Keyword(s):  
Escherichia Coli ◽  
Staphylococcus Aureus ◽  
Tea Tree Oil ◽  
Postantibiotic Effect ◽  
Melaleuca Alternifolia ◽  
Tea Tree
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