Leishmanicidal activity of racemic ± 8-[(4-Amino-1-methylbutyl)amino]-6-methoxy-4-methyl-5-[3,4-dichlorophenoxy]quinoline
2010 ◽
Vol 5
(3)
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pp. 1934578X1000500
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Keyword(s):
In this work we studied the in vitro toxicity of ± 8-[(4-Amino-1-Methylbutyl)Amino]-6-Methoxy-4-Methyl-5-[3,4-dichlorophenoxy]quinoline (DN3-27-1) against stationary phase promastigotes Leishmania (L.) mexicana. Our results indicate that this drug induces an important reduction in parasite growth and killing compared to the reference drug N-methyl meglumine (Glucantime™). DN3-27-1 was not toxic to Hela cells cultured in vitro. This is the first report describing the promising potential of DN3-27-1 in treatment of L. ( L.) m exicana infections.
2007 ◽
Vol 2
(1)
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pp. 1934578X0700200
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Keyword(s):
2018 ◽
Vol 63
(2)
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pp. e00904-18
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2000 ◽
Vol 19
(5)
◽
pp. 309-317
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Keyword(s):
2002 ◽
Vol 70
(11)
◽
pp. 6273-6283
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Keyword(s):
Keyword(s):