scholarly journals Levetiracetam induced hypomania: a case report

2019 ◽  
Vol 10 ◽  
pp. 204209861987675 ◽  
Author(s):  
Ali Ercan Altınöz ◽  
Şengül Tosun Altınöz ◽  
Başak Güzel Biltekin ◽  
Murat Can Kaya
Keyword(s):  
Case Report ◽  
Psychiatric Disorder ◽  
Psychological Symptoms ◽  
Case Reports ◽  
Psychotic Symptoms ◽  
Drug Reactions ◽  
Manic Symptoms ◽  
Epilepsy Treatment ◽  
History Of ◽  
Clonic Seizures

Levetiracetam (LEV) is a newer second-generation antiepileptic drug that is found to be effective in tonic-clonic seizures, partial onset seizures, and myoclonic seizures. Among antiepileptic drugs, LEV is usually known for fewer adverse drug reactions. Psychiatric disorders after the administration of LEV have been reported in the literature. There are many case reports on LEV-induced psychosis, but there are only three case reports of mania induced by LEV use. In this report, we present a case with no history of psychiatric disorder who had a hypomania episode after receiving LEV for epilepsy treatment. The development of manic symptoms with LEV therapy is unusual. Clinicians should consider monitoring patients closely for treatment-related psychological symptoms and psychotic symptoms, including the possibility of mania.

scholarly journals Psychiatric Symptomatology in Early-Onset Binswanger’s Disease: Two Case Reports

1995 ◽  
Vol 8 (1) ◽  
pp. 43-46 ◽  
Author(s):  
R. M. Lawrence ◽  
J. C. Hillam
Keyword(s):  
Early Identification ◽  
Psychiatric Illness ◽  
Case Reports ◽  
Accurate Diagnosis ◽  
Psychotic Symptoms ◽  
Psychiatric Symptomatology ◽  
Neurological Signs ◽  
Binswanger’S Disease ◽  
History Of ◽  
Binswanger's Disease

We describe two cases of Binswanger's disease of pre-senile onset which presented with affective and psychotic symptoms well before the appearance of cognitive deterioration and neurological signs, initially evading an accurate diagnosis. Psychiatrists should be aware of white matter disease and its role in the pathogenesis of psychiatric illness. Particular attention should be given to a history of hypertension as a risk factor in the early identification of these cases.

scholarly journals Metastatic Pancreatic Cancer with BRAF and P53 Mutations: Case Report of Therapeutic Response to Doublet Targeted Therapy

2020 ◽  
Vol 13 (3) ◽  
pp. 1239-1243
Author(s):  
Shenthol Sasankan ◽  
Lorraine Rebuck ◽  
Gloria Darrah ◽  
Moises Harari Turquie ◽  
Ian Rabinowitz
Keyword(s):  
Pancreatic Cancer ◽  
Case Report ◽  
Targeted Therapy ◽  
Therapeutic Response ◽  
Case Reports ◽  
Clinical History ◽  
P53 Mutation ◽  
Metastatic Pancreatic Cancer ◽  
First Case ◽  
History Of

We report on the clinical history of a 49-year-old female with metastatic pancreatic cancer. She was initially treated with standard chemotherapy as per current guidelines. She was found to have both a BRAF and P53 mutation, and received dabrafenib and trametinib with deep responses, both radiographically and biochemically (CA19-9). Her response has been more clinically relevant than responses in previous case reports of patients with BRAF-positive pancreatic cancer treated with targeted therapy. To the best of our knowledge, this is the first case report showing a dramatic therapeutic response to combination therapy with dabrafenib and trametinib in metastatic pancreatic cancer.

Agranulocytosis Associated with Waldenström Macroglobulinemia

2018 ◽  
Vol 140 (1) ◽  
pp. 42-45 ◽  
Author(s):  
Iuliana Vaxman ◽  
Daniel Shepshelovich ◽  
Lucille Hayman ◽  
Pia Raanani ◽  
Meir Lahav
Keyword(s):  
Case Report ◽  
Febrile Neutropenia ◽  
Medical History ◽  
Case Reports ◽  
Neutropenic Fever ◽  
Severe Neutropenia ◽  
Past Medical History ◽  
Waldenström Macroglobulinemia ◽  
Waldenstrom Macroglobulinemia ◽  
History Of

Currently, there are only 2 case reports of Waldenström macroglobulinemia (WM) associated with severe neutropenia. This is a case report of a woman with a past medical history of WM who presented with neutropenic fever. The patient’s febrile neutropenia resolved after RCD chemotherapy (cyclophosphamide 750 mg/m2, dexamethasone 20 mg, and rituximab 375 mg/m2). Fourteen days after administration, the neutrophil level had started to rise and normalized after 6 days. To the best of our knowledge, this is the 3rd reported case of agranulocytosis due to WM.

scholarly journals A profile of adult acute admissions to Lentegeur Psychiatric Hospital, South Africa

2019 ◽  
Vol 25 ◽  
Author(s):  
Herman Franken ◽  
John Parker ◽  
Robin Allen ◽  
Robert A. Wicomb
Keyword(s):  
South Africa ◽  
Psychiatric Hospital ◽  
Common Mental Disorders ◽  
Psychotic Symptoms ◽  
First Episode ◽  
Western Cape ◽  
Violent Behaviour ◽  
Manic Symptoms ◽  
History Of ◽  
Clinical Records

Background: The Western Cape province has the highest documented lifetime prevalence of common mental disorders in South Africa. To ensure the efficient, equitable and effective distribution of current resources, there is a need to determine the profile of patients requiring psychiatric admission.Aim: To describe patients admitted to the acute adult admissions unit at Lentegeur Hospital.Setting: Lentegeur Psychiatric Hospital is situated in Mitchells Plain, Cape Town, and serves about 1 million people from nearby urban and rural areas.Methods: This retrospective study involved an audit of all patients (18–60 years of age) admitted between 01 January 2016 and 30 June 2016. The clinical records of 573 adult patients were examined.Results: The median age of the cohort was 29 years. Most patients (63%) were educated to the secondary level. Only 12% of the patients were employed, and 37% received disability grants. More than 90% of the patients presented with psychotic symptoms. Of these, 28% presented with a first-episode of psychosis. Of all patients, 20% were referred with manic symptoms and 7% with depressive symptoms. Many patients (62%) used substances concurrently in the period leading up to admission. Significantly more males (73%) used substances compared to females (38%). Cannabis was the most widely used substance (51%), followed by methamphetamine (36%). Recent violent behaviour contributed to 37% of the current admissions. A total of 70 patients (13%) tested positive for human immunodeficiency virus (HIV), and 49 (9%) tested positive for syphilis.Conclusion: Substance use and a history of violence contributed to admissions in this population.

scholarly journals Temporomandibular joint alterations: two clinical case-reports of bifid condyle and temporomandibular joint ankylosis

Revista CEFAC ◽  
2019 ◽  
Vol 21 (2) ◽  
Author(s):  
Mariana Campos Limongi ◽  
Flávio Ricardo Manzi ◽  
José Benedito Fonseca Limongi
Keyword(s):  
Case Report ◽  
Temporomandibular Joint ◽  
Case Reports ◽  
Temporomandibular Joint Disorders ◽  
Psychological State ◽  
Facial Trauma ◽  
Temporomandibular Joint Ankylosis ◽  
History Of ◽  
Joint Ankylosis ◽  
Bifid Condyle

ABSTRACT The etiology of alterations of the temporomandibular joint, such as ankylosis and bifid condyle, comprises several causes including trauma. However, otological infections cannot be overlooked as a probable cause of alterations of the temporomandibular joint, because the proximity between the external auditory canal and the temporomandibular joint facilitates the spread of infection in the region. This article presents a case-report of a patient with bifid condyle of the temporomandibular joint, in which the patient had no history of facial trauma, but had suffered recurrent otitis infections during her childhood. In parallel, a second case-report is described of temporomandibular joint ankylosis in a 12-year-old patient with a history of facial trauma during her childhood. The purpose of this study was to highlight and emphasize the importance of early diagnosis of temporomandibular joint disorders to avoid the development of facial asymmetries, restore function, esthetics, and the psychological state of the patient.

scholarly journals Adolescent Catatonia Successfully Treated with Lorazepam and Aripiprazole

2014 ◽  
Vol 2014 ◽  
pp. 1-4 ◽  
Author(s):  
Aaron J. Roberto ◽  
Subhash Pinnaka ◽  
Abhishek Mohan ◽  
Hiejin Yoon ◽  
Kyle A. B. Lapidus
Keyword(s):  
Case Report ◽  
Children And Adolescents ◽  
Emotional Distress ◽  
Successful Treatment ◽  
Previous History ◽  
Treatment Modalities ◽  
Psychotic Symptoms ◽  
First Episode ◽  
Significant Impairment ◽  
History Of

Catatonia is especially concerning in children and adolescents. It leads to significant impairment, including emotional distress, difficulty communicating, and other debilitating symptoms. In this case report, we discuss a patient with no previous history of neuroleptic medication or psychotic symptoms, presenting with first-episode catatonia in the presence of disorganized, psychotic thoughts. We then review the catatonia syndrome, citing examples in the literature supporting its underdiagnosis in children and adolescents, and discuss successful treatment modalities. It is important to diagnose and treat catatonia as efficiently as possible, to limit functional and emotional distress to the patient.

Promethazine Treatment of Steroid-Induced Psychosis in a Child

2003 ◽  
Vol 37 (7-8) ◽  
pp. 1036-1039 ◽  
Author(s):  
Dena G Ingram ◽  
Tracy M Hagemann
Keyword(s):  
Psychological Symptoms ◽  
Lymphoblastic Leukemia ◽  
Marrow Transplant ◽  
Psychotic Symptoms ◽  
Phenothiazine Derivative ◽  
Graft Versus Host ◽  
Case Summary ◽  
History Of ◽  
Excessive Crying ◽  
Typical Treatment

OBJECTIVE: To report a case of steroid-induced psychosis in a child that resolved with the treatment of promethazine, a phenothiazine derivative. CASE SUMMARY: A 2-year-old white boy with a history of relapsed acute lymphoblastic leukemia underwent a bone marrow transplant and developed graft-versus-host disease, which was treated with methylprednisolone. Within 24 hours of initiation of the methylprednisolone, the patient developed symptoms associated with steroid-induced psychosis including mania, head-banging, and excessive crying. Because the corticosteroid could not be discontinued, promethazine, a phenothiazine derivative, was used to treat the psychotic symptoms. Symptoms resolved with use of promethazine. DISCUSSION: A number of published reports describe the appearance of psychological symptoms with corticosteroid use. While the mechanism is unclear, the reaction is usually reversible with dose reduction or discontinuation of the corticosteroid. In cases where this cannot be done, typical treatment involves an antipsychotic medication. Most antipsychotic medications, such as the phenothiazine class, have not been evaluated in very young childen. Promethazine is a phenothiazine derivative that has been used in children for a number of nonpsychiatric indications. CONCLUSIONS: Promethazine may be effective in treating steroid-induced psychosis in pediatric patients.

CASE REPORT: POURFOUR DU PETIT SYNDROME IN A PATIENT WITH MIGRAINE

2015 ◽  
Vol 86 (11) ◽  
pp. e4.169-e4
Author(s):  
Aseel Al-Ansari ◽  
Richard Jon Llewellyn Walters
Keyword(s):  
Case Report ◽  
Case Reports ◽  
Sympathetic Chain ◽  
Horner’S Syndrome ◽  
Eyelid Retraction ◽  
Horner's Syndrome ◽  
Blurred Vision ◽  
History Of ◽  
Cervical Sympathetic ◽  
Unusual Symptoms

A 45-year old woman presented with a twelve-month history of intense migraines. She described episodes of blurred vision in association with the headaches, during which she invariably found that one or other of her pupils became dilated with a degree of eyelid retraction on the affected side. These unusual symptoms resolved spontaneously with improvement of the headache.After exclusion of a lesional cause with brain and neck imaging, we concluded that her symptoms were secondary to autonomic dysfunction in relation to her headache.Horner's syndrome is due to paralysis of the ipsilateral cervical sympathetic chain and comprises ptosis, miosis, enopthalmos and anhidrosis. A Reverse Horner's syndrome, otherwise known as Pourfour du Petit, in theory, is the opposite, and comprises eyelid retraction, mydriasis and hyperhidrosis. Where documented, it is attributed to irritation, rather than complete deficiency of the ipsilateral sympathetic chain. Previous case reports have shown that Pourfour du Petit can occur due to the same mechanisms as a Horner's syndrome. In only one other case report has it been described as an autonomic feature in relation to headache.

Mania following antidepressant discontinuation in depression: two case reports

2017 ◽  
Vol 25 (6) ◽  
pp. 617-621 ◽  
Author(s):  
Cecilia Sze Nga Kwok ◽  
Leslie Eng Choon Lim
Keyword(s):  
Selective Serotonin Reuptake Inhibitors ◽  
Tricyclic Antidepressants ◽  
Standard Treatment ◽  
Late Onset ◽  
Case Reports ◽  
Asian Population ◽  
Unipolar Depression ◽  
Chinese Patients ◽  
Manic Symptoms ◽  
History Of

Objective: Antidepressant-induced mania and an antidepressant discontinuation syndrome are well documented, whereas mania occurring after antidepressant cessation has been infrequently reported. Method: We describe antidepressant discontinuation-related mania in two Chinese patients, as well as a review of the literature on this phenomenon in unipolar depression. Results: A 72-year-old man and a 65-year-old woman had late-onset depression with vascular risk factors, but no personal or family history of mood disorders. Manic symptoms started after stopping escitalopram and venlafaxine during depressive relapse, and resolved with the initiation of olanzapine and valproate. In the literature, 29 episodes of antidepressant discontinuation-related mania were reported. Tricyclic antidepressants were most frequently implicated, followed by selective serotonin reuptake inhibitors. There was spontaneous resolution of manic symptoms in half of the cases. Conclusion: This is the first report of antidepressant discontinuation-related mania in an Asian population, in the setting of late-onset depression. This phenomenon is rare and is amenable to standard treatment.

scholarly journals Persistent delusional theme over 13 episodes of psychotic depression

2013 ◽  
Vol 25 (6) ◽  
pp. 370-373 ◽  
Author(s):  
Søren Dinesen Østergaard ◽  
Anne Katrine K. Leadholm ◽  
Anthony J. Rothschild
Keyword(s):  
Case Report ◽  
Electroconvulsive Therapy ◽  
Case Reports ◽  
Psychotic Symptoms ◽  
Psychotic Depression ◽  
Medical File ◽  
Course Of Illness ◽  
Clinical Phenomenon ◽  
Initial Episode ◽  
Multiple Episodes

ObjectiveUnipolar psychotic depression (PD) is a highly debilitating condition, which needs intense monitoring and treatment. Among patients with recurrent PD, delusions tend to be very similar or identical over several separate episodes during the course of illness, but case reports illustrating this clinical phenomenon in detail are lacking from the literature.MethodsCase report describing the 45-year-old Ms. J, who has experienced multiple episodes of PD. The report is based on a review of her medical file.ResultsThe delusional theme of Ms. J's initial episode of PD reappeared at several subsequent episodes. During the majority of admissions, Ms. J was treated with electroconvulsive therapy, which resulted in significant improvement in the depressive, psychotic and catatonic features.ConclusionMs. J's case illustrates that PD can be a stable phenotype over many episodes and that it is important to recognise psychotic symptoms in order to prescribe the best possible treatment.

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