scholarly journals Echocardiographic estimation of right ventricular wall tension: haemodynamic comparison and long-term follow-up

2019 ◽  
Vol 9 (4) ◽  
pp. 204589401989542 ◽  
Author(s):  
Umberto Annone ◽  
Pier P. Bocchino ◽  
Walter G. Marra ◽  
Fabrizio D’Ascenzo ◽  
Corrado Magnino ◽  
...  
Keyword(s):  
Pulmonary Hypertension ◽  
Right Ventricle ◽  
Right Ventricular ◽  
Tricuspid Regurgitation ◽  
Ventricular Wall ◽  
Wall Tension ◽  
Right Ventricular Wall ◽  
Right Ventricle Failure ◽  
Peak Gradient

Prognosis in pulmonary hypertension is strictly linked to right ventricle failure, which results from uncoupling between right ventricle function and its afterload. This study sought to describe how to estimate with echocardiography right ventricular wall tension, its correlation with right ventricle haemodynamics and its prognostic role. A total of 190 patients without overt right ventricle failure but with suspected pulmonary hypertension on a previous echocardiogram underwent right heart catheterization and nearly-simultaneous echocardiography. Right ventricular wall tension was estimated according to Laplace’s law as right ventricle length × tricuspid regurgitation peak gradient and it was correlated with right ventricle haemodynamic profile; its potential prognostic impact was tested along with canonical right ventricle function parameters. Right ventricular wall tension correlated significantly with invasive estimation of right ventricle end-diastolic pressure (R: 0.343, p < 0.001) and with several other haemodynamic variables, such as mean pulmonary artery pressure, pulmonary artery compliance, transpulmonary gradient, pulmonary vascular resistance, right atrial pressure and right ventricle stroke work index (all p < 0.001). At a mean follow-up of five years and three months, only right ventricular wall tension was associated to all-cause mortality ( p = 0.036), while tricuspid annular plane systolic excursion ( p = 0.536), right ventricle fractional area change ( p = 0.383), right ventricle fractional area change ( p = 0.076), tricuspid regurgitation peak gradient ( p = 0.107) and tricuspid annular plane systolic excursion/tricuspid regurgitation peak gradient ( p = 0.181) could not. We identified a novel bedside echocardiographic predictor of altered right ventricle haemodynamics, which is precociously altered in patients without overt right ventricle failure and is associated to all-cause mortality at a long-term follow-up. Further studies are needed to confirm its role in pulmonary hypertension patients.

scholarly journals Prognostic Implications of Increased Right Ventricular Wall Tension in Secondary Tricuspid Regurgitation

2020 ◽  
Vol 136 ◽  
pp. 131-139
Author(s):  
Federico Fortuni ◽  
Marlieke F. Dietz ◽  
Steele C. Butcher ◽  
Edgard A. Prihadi ◽  
Pieter van der Bijl ◽  
...  
Keyword(s):  
Right Ventricular ◽  
Tricuspid Regurgitation ◽  
Ventricular Wall ◽  
Wall Tension ◽  
Right Ventricular Wall ◽  
Prognostic Implications

The clinical significance and prognostic value of right ventricular wall tension in moderate or severe tricuspid regurgitation

2021 ◽  
Author(s):  
Sahrai Saeed ◽  
Karine Grigoryan ◽  
Jenna Smith ◽  
Harminder Gill ◽  
Dario Freitas ◽  
...  
Keyword(s):  
Right Ventricular ◽  
Tricuspid Regurgitation ◽  
Systolic Pulmonary Artery Pressure ◽  
Ventricular Wall ◽  
Wall Tension ◽  
Severe Tricuspid Regurgitation ◽  
All Cause Mortality ◽  
Right Ventricular Wall ◽  
Adjusted Model ◽  
Independent Determinant

Background: We aim to explore the determinants of right ventricular wall tension (RV WT [RV base-to-apex length multiplied by systolic pulmonary artery pressure] and association with all-cause mortality in patients with moderate-to-severe tricuspid regurgitation. Materials & methods: Of total, 180 patients (71 ± 15years, 54% females) were included. An increased RV WT was defined as >3300 mmHgxmm. Results: Patients with increased RV WT (n = 85, 47%) were more likely to be male and taller than patients with normal RV WT. In a multivariable-adjusted model, increased RV WT was associated with a 2.6-fold higher risk of all-cause mortality (HR: 2.59, 95% CI: 1.65–4.06). Conclusion: In patients with significant tricuspid regurgitation, an increased RV WT was common, and associated with a 2.6-fold higher risk of all-cause mortality. Male sex was the only independent determinant.

Uhl’s anomaly: rare but does exist

2016 ◽  
Vol 26 (7) ◽  
pp. 563-565
Author(s):  
Parveen Kumar ◽  
Hemant Chaturvedi ◽  
Payal Khatri ◽  
Sanjay Khatri
Keyword(s):  
Right Ventricle ◽  
Right Ventricular ◽  
Systolic Dysfunction ◽  
Lower Limbs ◽  
Ventricular Wall ◽  
Ventricular Systolic Dysfunction ◽  
Resonance Imaging ◽  
Right Ventricular Wall ◽  
Thin Walled ◽  
The Right

A 17-year-old boy presented with facial puffiness and swelling in the lower limbs for 6 months and one episode of syncope 15 days earlier. Transthoracic echocardiography showed a dilated right atrium and right ventricle with right ventricular systolic dysfunction. The free wall of the right ventricle was thinned out and devoid of myocardium and trabeculations. Cardiac magnetic resonance imaging showed an extremely dilated thin-walled right ventricle and absence of trabeculations, with no fat signal in the right ventricular wall, in contrast to that seen in arrhythmogenic ventricular dysplasia, which confirmed the diagnosis of Uhl’s anomaly.

scholarly journals The cardiac STAT3 intercalated disc specific expression in tail suspension rat

2021 ◽  
Author(s):  
Dongyu He ◽  
Aihua Hu ◽  
Jun Tong ◽  
Chang Zheng ◽  
Yiming Liu ◽  
...  
Keyword(s):  
Right Ventricle ◽  
Right Ventricular ◽  
Ventricular Wall ◽  
Tail Suspension ◽  
Intercalated Disc ◽  
Right Heart ◽  
Microgravity Simulation ◽  
Right Ventricular Wall ◽  
Specific Accumulation ◽  
The Right

Background: The cardiovascular system is significantly agitated by loss of gravity. In microgravity, the body fluids shift toward the thoracic cavity, induced the heart becomes more spherical. This further increased the cardiac preload with an increasing of transmural central venous pressure, affects the right heart ventricles to tolerating the enhanced preload on the right ventricular wall. Method: In this study we investigated the rat right ventricle remodeling in simulating persistent microgravity by using tail-suspension model, examined the remolding of the heart and the specific STAT3 expression in right heart myocardium. Result: The results indicated that microgravity induced heart remodeling included a significant increasing of the ventricular weight in the left. However, the right ventricle was not increased significantly in the microgravity simulation rats. The histological study demonstrated that the outstanding development on right ventricular wall which included the gap junction remodeling and STAT3 signaling protein specific accumulation in the right ventricles. Conclusion: The results existed that the right cardiac ventricle has a distinctive remodeling process during microgravity simulation which was not the muscular hypertrophy and relative weight increasing, but manifested the STAT3 accumulation and the electrical gap junction remodeling. The effect of microgravity induced right ventricle remodeling and the STAT3 specific accumulation can be used for multi-purpose research. Key words: Microgravity simulation; Right ventricle remodeling; Intercalated disc

scholarly journals Echocardiographic markers of pulmonary hemodynamics and right ventricular hypertrophy in rat models of pulmonary hypertension The first two authors contributed equally to this manuscript.

2020 ◽  
Vol 10 (2) ◽  
pp. 204589402091097
Author(s):  
Fotios Spyropoulos ◽  
Sally H. Vitali ◽  
Marlin Touma ◽  
Chase D. Rose ◽  
Carter R. Petty ◽  
...  
Keyword(s):  
Pulmonary Hypertension ◽  
Right Ventricular ◽  
Wall Thickness ◽  
Ventricular Wall ◽  
Right Ventricular Systolic Pressure ◽  
Acceleration Time ◽  
Non Invasive ◽  
Right Ventricular Wall ◽  
Ventricular Wall Thickness ◽  
Pulmonary Arterial

Echocardiography is the gold standard non-invasive technique to diagnose pulmonary hypertension. It is also an important modality used to monitor disease progression and response to treatment in patients with pulmonary hypertension. Surprisingly, only few studies have been conducted to validate and standardize echocardiographic parameters in experimental animal models of pulmonary hypertension. We sought to define cut-off values for both invasive and non-invasive measures of pulmonary hemodynamics and right ventricular hypertrophy that would reliably diagnose pulmonary hypertension in three different rat models. The study was designed in two phases: (1) a derivation phase to establish the cut-off values for invasive measures of right ventricular systolic pressure, Fulton's index (right ventricular weight/left ventricle + septum weight), right ventricular to body weight ratio, and non-invasive echocardiographic measures of pulmonary arterial acceleration time, pulmonary arterial acceleration time to ejection time ratio and right ventricular wall thickness in diastole in the hypoxic and monocrotaline rat models of pulmonary hypertension and (2) a validation phase to test the performance of the cut-off values in predicting pulmonary hypertension in an independent cohort of rats with Sugen/hypoxia-induced pulmonary hypertension. Our study demonstrates that right ventricular systolic pressure ≥35.5 mmHg and Fulton's Index ≥0.34 are highly sensitive (>94%) and specific (>91%) cut-offs to distinguish animals with pulmonary hypertension from controls. When pulmonary arterial acceleration time/ejection time and right ventricular wall thickness in diastole were both measured, a result of either pulmonary arterial acceleration time/ejection time ≤0.25 or right ventricular wall thickness in diastole ≥1.03 mm detected right ventricular systolic pressure ≥35.5 mmHg or Fulton's Index ≥0.34 with a sensitivity of 88% and specificity of 100%. With properly validated non-invasive echocardiography measures of right ventricular performance in rats that accurately predict invasive measures of pulmonary hemodynamics, future studies can now utilize these markers to test the efficacy of different treatments with preclinical therapeutic modeling.

scholarly journals Reconstruction of the right ventricle with diaphragm driven right ventricular wall device.

1982 ◽  
Vol 136 (2) ◽  
pp. 203-214 ◽  
Author(s):  
YUZURU KAGAWA ◽  
TADAYOSHI HONGO ◽  
SHINICHI NITTA ◽  
NAOSHI SATO ◽  
TAKASHI WATANABE ◽  
...  
Keyword(s):  
Right Ventricle ◽  
Right Ventricular ◽  
Ventricular Wall ◽  
Right Ventricular Wall ◽  
The Right
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