scholarly journals Reply to commentary on: Confusion in reporting pulmonary diffusion capacity for nitric oxide and the alveolar-capillary membrane conductance for nitric oxide

2014 ◽  
Vol 22 (3) ◽  
pp. 314-316
Author(s):  
Piergiuseppe Agostoni ◽  
Alessandra Magini ◽  
Anna Apostolo
2010 ◽  
Vol 24 (S1) ◽  
Author(s):  
Courtney M. Wheatley ◽  
Nicholas A. Cassuto ◽  
William T. Foxx‐Lupo ◽  
Eric C. Wong ◽  
Nicholas A. Delamere ◽  
...  

2000 ◽  
Vol 98 (6) ◽  
pp. 633-641 ◽  
Author(s):  
Marco GUAZZI

Chronic heart failure (CHF) disturbs the alveolar–capillary interface and increases the resistance to gas transfer. Alveolar–capillary membrane conductance (DM) and capillary blood volume (Vc) are subcomponents of the lung diffusion capacity. Elevation of the capillary pressure causes alveolar–capillary membrane stress failure (i.e. increase in capillary permeability to water and ions, and disruption of local regulatory mechanisms for gas exchange), leading to a decrease in DM, an increase in Vc and subsequent impairment of diffusion capacity. Renewed recent interest in abnormalities in lung diffusion in patients with CHF has brought about new pathophysiological insights. A significant contribution of the altered gas transfer to the pathogenesis of exercise limitation and ventilatory abnormalities has been reported, and DM has been identified as the best lung function predictor of oxygen uptake at peak exercise. This review examines the pathophysiological and clinical significance of assessing lung diffusion capacity in patients with CHF.


1973 ◽  
Vol 18 (3) ◽  
pp. 285-308 ◽  
Author(s):  
Ewald R. Weibel ◽  
Peter Untersee ◽  
Joan Gil ◽  
Martin Zulauf

1986 ◽  
Vol 4 (3) ◽  
pp. 185-188 ◽  
Author(s):  
B. S. Rasmussen ◽  
B. Hanel ◽  
K. Jensen ◽  
B. Serup ◽  
N.H. Secher

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