Association of C677T polymorphism in the methylenetetrahydrofolate reductase gene (MTHFR gene) with ischemic stroke: a meta-analysis

2015 ◽  
Vol 37 (7) ◽  
pp. 568-577 ◽  
Author(s):  
Amit Kumar ◽  
Pradeep Kumar ◽  
Manya Prasad ◽  
Ram Sagar ◽  
Arun Kumar Yadav ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Methylenetetrahydrofolate Reductase ◽  
Meta Analysis ◽  
Mthfr Gene ◽  
C677t Polymorphism ◽  
Reductase Gene ◽  
Methylenetetrahydrofolate Reductase Gene

scholarly journals Methylenetetrahydrofolate reductase gene C677T polymorphism and risk of alcohol dependence

2020 ◽  
Author(s):  
Vandana Rai ◽  
Pradeep Kumar
Keyword(s):  
Alcohol Dependence ◽  
Methylenetetrahydrofolate Reductase ◽  
Meta Analysis ◽  
Mthfr C677t ◽  
Mthfr Gene ◽  
Random Effects Model ◽  
C677t Polymorphism ◽  
Mthfr C677t Polymorphism ◽  
Reductase Gene ◽  
Methylenetetrahydrofolate Reductase Gene

AbstractAlcohol dependence is a complex neuropsychiatric disorder. Numerous studies investigated association between MTHFR gene C677T polymorphism and alcohol dependence (AD), but the results of this association remain conflicting. Accordingly, authors conducted a meta-analysis to further investigate such an association. PubMed, Elsevier Science Direct and Springer Link databases were searched for studies on the association between the MTHFR C677T polymorphism and AD. Pooled odds ratio (OR) with 95% confidence interval (CI) was calculated using the fixed- or random-effects model. Statistical analysis was performed with the software program MetaAnayst and MIX.A total of 11 articles were identified through a search of electronic databases, up to February 28, 2020. The results of the present meta-analysis did not show any association between MTHFR C677T polymorphisms and AD risk (for T vs. C: OR = 1.04, 95% CI = 0.88-1.24; CT vs. CC: OR=1.02, 95%CI= 0.62-1.68; for TT + CT vs. CC: OR = 1.10, 95% CI = 0.94-1.29; for TT vs. CC: OR = 1.01, 95% CI = 0.66-1.51; for TT vs. CT + CC: OR = 0.97, 95% CI = 0.66-1.40). Results of subgroup analysis showed no significant association between MTHFR C677T polymorphism with AD in Asian as well as in Caucasian population. In conclusion, C677T polymorphism is not a risk factor for alcohol dependence.

The C677T Polymorphism of the Methylenetetrahydrofolate Reductase Gene Is Associated with Idiopathic Ischemic Stroke in the Young Mexican-Mestizo Population

2010 ◽  
Vol 29 (5) ◽  
pp. 454-459 ◽  
Author(s):  
Irma Isordia-Salas ◽  
Fernando Barinagarrementería-Aldatz ◽  
Alfredo Leaños-Miranda ◽  
Gabriela Borrayo-Sánchez ◽  
Jorge Vela-Ojeda ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Methylenetetrahydrofolate Reductase ◽  
C677t Polymorphism ◽  
Mexican Mestizo ◽  
Reductase Gene ◽  
Stroke In The Young ◽  
Mexican Mestizo Population ◽  
Methylenetetrahydrofolate Reductase Gene
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