First Trimester Antenatal Screening for Down's Syndrome: A Review of Reliability and Validity

Ultrasound ◽  
2005 ◽  
Vol 13 (4) ◽  
pp. 226-230 ◽  
Author(s):  
B. Stenberg ◽  
R. Lee ◽  
A. M. Dixon
Keyword(s):  
Undergraduate Research ◽  
Down's Syndrome ◽  
Reliability And Validity ◽  
Down’S Syndrome ◽  
First Trimester ◽  
Antenatal Screening ◽  
Trimester Screening ◽  
Research Regulations ◽  
The University

This review is based on a third-year undergraduate project undertaken by Ben Stenberg and submitted as part of a BSc (Honours) Radiography award at the University of Teesside. The project and this report reviews the concept of antenatal screening for Down's syndrome, it explores the role of ultrasound and other available tests, and considers sensitivities and potential for errors in a first trimester screening service. The review employs library based literature review methodology and its limitations reflect the size and scope of projects performed within undergraduate research regulations.

OC04.01: Newborn with Down's syndrome: first trimester screening or not?

2014 ◽  
Vol 44 (S1) ◽  
pp. 7-8
Author(s):  
C.B. Miltoft ◽  
C.B. Wulff ◽  
S. Kjaergaard ◽  
C.K. Ekelund ◽  
A. Tabor
Keyword(s):  
Down's Syndrome ◽  
Down’S Syndrome ◽  
First Trimester ◽  
First Trimester Screening ◽  
Trimester Screening

First-trimester screening for Down’s syndrome in in vitro fertilization pregnancies

2001 ◽  
Vol 76 (6) ◽  
pp. 1282-1283 ◽  
Author(s):  
Marko Niemimaa ◽  
Seppo Heinonen ◽  
Maija Seppälä ◽  
Marita Hippeläinen ◽  
Hannu Martikainen ◽  
...  
Keyword(s):  
In Vitro Fertilization ◽  
Down's Syndrome ◽  
Down’S Syndrome ◽  
First Trimester ◽  
First Trimester Screening ◽  
Vitro Fertilization ◽  
Trimester Screening

Importance of the integrated test in the Down’s syndrome screening algorithm

2018 ◽  
Vol 25 (3) ◽  
pp. 114-118
Author(s):  
Drahomira Springer ◽  
Jaroslav Loucky ◽  
Pavel Tesner ◽  
David Cutka ◽  
David Stejskal ◽  
...  
Keyword(s):  
Screening Program ◽  
Down's Syndrome ◽  
Down’S Syndrome ◽  
First Trimester ◽  
Sequential Test ◽  
Congenital Defects ◽  
Antenatal Screening ◽  
Second Trimester ◽  
Second Trimester Screening ◽  
The Impact

Objective In the Czech Republic, over 97% of all pregnant women undergo some type of antenatal screening for Down’s syndrome. In about 95% of cases with a confirmed fetal chromosomal abnormality, the pregnancy is terminated. The most commonly used test is the first trimester combined test. We investigated the impact of implementing an integrated sequential test to improve the detection of Down’s syndrome pregnancies. Methods Data on the incidence of congenital defects, number of births, and affected pregnancies terminated are recorded in the National Registry of Congenital Anomalies. Anonymous data on cases of Down’s syndrome diagnosed antenatally or postnatally between 2010 and 2015 in one of the large antenatal care centers were analyzed. Results There were 600 diagnoses of Down’s syndrome (5.7 per 1000 births), 90% of which were made antenatally. Of antenatally detected cases, 80% were indicated for diagnostic procedure by multimarker screening results. In the multimarker screen positive group, 75% cases were first trimester positive and 25% second trimester positive (most of these had positive integrated test results). Among Down’s syndrome cases indicated for antenatal diagnosis by multimarker screening results 6.25% (n = 26) were first trimester negative, and became positive after integration with the second trimester screening results. Conclusions Results from five major Czech antenatal centers confirm that an integrated sequential test would detect 80–85% of Down’s syndrome fetuses in the first trimester and at least an extra 5–10% of Down’s syndrome pregnancies in the second trimester of pregnancy. These are important data that should be considered in implementing the national antenatal screening program.

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