Revisions to the staging and classification of mycosis fungoides and Sézary syndrome: a proposal of the International Society for Cutaneous Lymphomas (ISCL) and the cutaneous lymphoma task force of the European Organization of Research and Treatment of Cancer (EORTC)

Blood ◽  
2007 ◽  
Vol 110 (6) ◽  
pp. 1713-1722 ◽  
Author(s):  
Elise Olsen ◽  
Eric Vonderheid ◽  
Nicola Pimpinelli ◽  
Rein Willemze ◽  
Youn Kim ◽  
...  
Keyword(s):  
Mycosis Fungoides ◽  
Cell Biology ◽  
Task Force ◽  
Prognostic Significance ◽  
Staging System ◽  
Cutaneous Lymphoma ◽  
Sézary Syndrome ◽  
Sezary Syndrome ◽  
European Organization ◽  
Cutaneous Lymphomas

Abstract The ISCL/EORTC recommends revisions to the Mycosis Fungoides Cooperative Group classification and staging system for cutaneous T-cell lymphoma (CTCL). These revisions are made to incorporate advances related to tumor cell biology and diagnostic techniques as pertains to mycosis fungoides (MF) and Sézary syndrome (SS) since the 1979 publication of the original guidelines, to clarify certain variables that currently impede effective interinstitution and interinvestigator communication and/or the development of standardized clinical trials in MF and SS, and to provide a platform for tracking other variables of potential prognostic significance. Moreover, given the difference in prognosis and clinical characteristics of the non-MF/non-SS subtypes of cutaneous lymphoma, this revision pertains specifically to MF and SS. The evidence supporting the revisions is discussed as well as recommendations for evaluation and staging procedures based on these revisions.

TNM classification system for primary cutaneous lymphomas other than mycosis fungoides and Sézary syndrome: a proposal of the International Society for Cutaneous Lymphomas (ISCL) and the Cutaneous Lymphoma Task Force of the European Organization of Research and Treatment of Cancer (EORTC)

Blood ◽  
2007 ◽  
Vol 110 (2) ◽  
pp. 479-484 ◽  
Author(s):  
Youn H. Kim ◽  
Rein Willemze ◽  
Nicola Pimpinelli ◽  
Sean Whittaker ◽  
Elise A. Olsen ◽  
...  
Keyword(s):  
Mycosis Fungoides ◽  
International Society ◽  
Classification System ◽  
Task Force ◽  
Tnm Classification ◽  
Cutaneous Lymphoma ◽  
Sézary Syndrome ◽  
European Organization ◽  
Tnm System ◽  
Cutaneous Lymphomas

Abstract Currently availabel staging systems for non-Hodgkin lymphomas are not useful for clinical staging classification of most primary cutaneous lymphomas. The tumor, node, metastases (TNM) system used for mycosis fungoides (MF) and Sézary syndrome (SS) is not appropriate for other primary cutaneous lymphomas. A usable, unified staging system would improve the communication about the state of disease, selection of appropriate management, standardization of enrollment/response criteria in clinical trials, and collection/analysis of prospective survival data. Toward this goal, during the recent meetings of the International Society for Cutaneous Lymphomas (ISCL) and the cutaneous lymphoma task force of the European Organization of Research and Treatment of Cancer (EORTC), the representatives have established a consensus proposal of a TNM classification system applicable for all primary cutaneous lymphomas other than MF and SS. Due to the clinical and pathologic heterogeneity of the cutaneous lymphomas, the currently proposed TNM system is meant to be primarily an anatomic documentation of disease extent and not to be used as a prognostic guide.

scholarly journals Clinical End Points and Response Criteria in Mycosis Fungoides and Sézary Syndrome: A Consensus Statement of the International Society for Cutaneous Lymphomas, the United States Cutaneous Lymphoma Consortium, and the Cutaneous Lymphoma Task Force of the European Organisation for Research and Treatment of Cancer

2011 ◽  
Vol 29 (18) ◽  
pp. 2598-2607 ◽  
Author(s):  
Elise A. Olsen ◽  
Sean Whittaker ◽  
Youn H. Kim ◽  
Madeleine Duvic ◽  
H. Miles Prince ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Mycosis Fungoides ◽  
The United States ◽  
Cutaneous Lymphoma ◽  
Response Criteria ◽  
Sézary Syndrome ◽  
Sezary Syndrome ◽  
End Points ◽  
Cutaneous Lymphomas ◽  
Hodgkin's Lymphomas

Mycosis fungoides (MF) and Sézary syndrome (SS), the major forms of cutaneous T-cell lymphoma, have unique characteristics that distinguish them from other types of non-Hodgkin's lymphomas. Clinical trials in MF/SS have suffered from a lack of standardization in evaluation, staging, assessment, end points, and response criteria. Recently defined criteria for the diagnosis of early MF, guidelines for initial evaluation, and revised staging and classification criteria for MF and SS now offer the potential for uniform staging of patients enrolled in clinical trials for MF/SS. This article presents consensus recommendations for the general conduct of clinical trials of patients with MF/SS as well as methods for standardized assessment of potential disease manifestations in skin, lymph nodes, blood, and visceral organs, and definition of end points and response criteria. These guidelines should facilitate collaboration among investigators and collation of data from sponsor-generated or investigator-initiated clinical trials involving patients with MF or SS.

scholarly journals Therapeutic and prognostic significance of PARP-1 in advanced mycosis fungoides and Sezary syndrome

2017 ◽  
Vol 27 (2) ◽  
pp. 188-190 ◽  
Author(s):  
David Lemchak ◽  
Swati Banerjee ◽  
Shaunak S. Digambar ◽  
Brian L. Hood ◽  
Thomas P. Conrads ◽  
...  
Keyword(s):  
Mycosis Fungoides ◽  
Prognostic Significance ◽  
Sézary Syndrome ◽  
Sezary Syndrome ◽  
Parp 1

scholarly journals Mycosis fungoides and Sézary syndrome: clinical, histopathological and immunohistochemical review and update

2012 ◽  
Vol 87 (6) ◽  
pp. 817-830 ◽  
Author(s):  
Thamy Yamashita ◽  
Luciana Patricia Fernandes Abbade ◽  
Mariangela Esther Alencar Marques ◽  
Silvio Alencar Marques
Keyword(s):  
Diagnostic Criteria ◽  
Mycosis Fungoides ◽  
Staging System ◽  
Great Variability ◽  
Sézary Syndrome ◽  
Sezary Syndrome ◽  
Clinical Expression ◽  
Early Stages

This paper reviews the diagnostic and classificatory concepts of mycosis fungoides and Sézary syndrome in light of the latest normative publications. It describes the great variability of the clinical expression of mycosis fungoides in its early stages as well as the histopathological and immunohistochemical aspects that help with diagnosis. The diagnostic criteria required for characterizing Sézary syndrome and the staging system used for both mycosis fungoides and Sézary syndrome are described.

Sign in / Sign up

Export Citation Format

Share Document