scholarly journals Elucidating the role of interleukin-17F in cutaneous T-cell lymphoma

Blood ◽  
2013 ◽  
Vol 122 (6) ◽  
pp. 943-950 ◽  
Author(s):  
Thorbjørn Krejsgaard ◽  
Ivan V. Litvinov ◽  
Yang Wang ◽  
Lixin Xia ◽  
Andreas Willerslev-Olsen ◽  
...  
Keyword(s):  
T Cell ◽  
Progressive Disease ◽  
Cell Lymphoma ◽  
T Cell Lymphoma ◽  
Cutaneous T Cell Lymphoma ◽  
Stat3 Pathway ◽  
Key Points ◽  
Interleukin 17F

Key Points The Jak/Stat3 pathway promotes the expression of IL-17F in malignant CTCL cells. IL-17F is highly expressed in a subset of CTCL patients and associated with progressive disease.

scholarly journals Staphylococcal enterotoxin A (SEA) stimulates STAT3 activation and IL-17 expression in cutaneous T-cell lymphoma

Blood ◽  
2016 ◽  
Vol 127 (10) ◽  
pp. 1287-1296 ◽  
Author(s):  
Andreas Willerslev-Olsen ◽  
Thorbjørn Krejsgaard ◽  
Lise M. Lindahl ◽  
Ivan V. Litvinov ◽  
Simon Fredholm ◽  
...  
Keyword(s):  
T Cell ◽  
Disease Progression ◽  
Cell Lymphoma ◽  
Staphylococcal Enterotoxin ◽  
T Cell Lymphoma ◽  
Cutaneous T Cell Lymphoma ◽  
Staphylococcal Enterotoxin A ◽  
Oncogenic Pathways ◽  
Key Points

Key Points Staphylococcal enterotoxins activate oncogenic pathways in CTCL. This discovery implies a novel role of microbes as drivers of disease progression.

scholarly journals Diminished microRNA-29b level is associated with BRD4-mediated activation of oncogenes in cutaneous T-cell lymphoma

Blood ◽  
2018 ◽  
Vol 131 (7) ◽  
pp. 771-781 ◽  
Author(s):  
Rebecca Kohnken ◽  
Jing Wen ◽  
Bethany Mundy-Bosse ◽  
Kathleen McConnell ◽  
Ashleigh Keiter ◽  
...  
Keyword(s):  
T Cell ◽  
Disease Severity ◽  
Cell Lymphoma ◽  
T Cell Lymphoma ◽  
Cutaneous T Cell Lymphoma ◽  
Promoter Regions ◽  
Therapeutic Targeting ◽  
Key Points

Key Points CTCL patients have decreased miR-29b levels and increased BRD4 binding occupancy at promoter regions of tumor-associated genes. Therapeutic targeting of miR-29b and BRD4 in CTCL mice results in significantly decreased disease severity and progression.

Exploring the role of the skin microenvironment in cutaneous T-cell lymphoma using single cell RNA-sequencing

2021 ◽  
Vol 156 ◽  
pp. S3-S4
Author(s):  
Gabor Dobos ◽  
Andreea Calugareanu ◽  
Laurence Michel ◽  
Maxime Battistella ◽  
Caroline Ram-Wolff ◽  
...  
Keyword(s):  
T Cell ◽  
Single Cell ◽  
Rna Sequencing ◽  
Cell Lymphoma ◽  
T Cell Lymphoma ◽  
Cutaneous T Cell Lymphoma ◽  
Single Cell Rna Sequencing

scholarly journals MDM2 Inhibitor Nutlin-3a Induces Apoptosis and Senescence in Cutaneous T-Cell Lymphoma: Role of p53

2012 ◽  
Vol 132 (5) ◽  
pp. 1487-1496 ◽  
Author(s):  
Valentina Manfé ◽  
Edyta Biskup ◽  
Peter Johansen ◽  
Maria R. Kamstrup ◽  
Thorbjørn F. Krejsgaard ◽  
...  
Keyword(s):  
T Cell ◽  
Cell Lymphoma ◽  
T Cell Lymphoma ◽  
Cutaneous T Cell Lymphoma ◽  
Mdm2 Inhibitor

Role of bexarotene in the treatment of cutaneous T-cell lymphoma: the clinical and immunological sides

Immunotherapy ◽  
2013 ◽  
Vol 5 (4) ◽  
pp. 427-433 ◽  
Author(s):  
Alessandro Pileri ◽  
Chiara Delfino ◽  
Vieri Grandi ◽  
Nicola Pimpinelli
Keyword(s):  
T Cell ◽  
Cell Lymphoma ◽  
T Cell Lymphoma ◽  
Cutaneous T Cell Lymphoma

scholarly journals The role of cytokine signaling in the pathogenesis of cutaneous T-cell lymphoma

2011 ◽  
Vol 12 (12) ◽  
pp. 1019-1022 ◽  
Author(s):  
Ronnie M. Abraham ◽  
Qian Zhang ◽  
Niels Odum ◽  
Mariusz A. Wasik
Keyword(s):  
T Cell ◽  
Cell Lymphoma ◽  
T Cell Lymphoma ◽  
Cytokine Signaling ◽  
Cutaneous T Cell Lymphoma

scholarly journals The role of AHI1 and CDKN1C in cutaneous T-cell lymphoma progression

2012 ◽  
Vol 21 (12) ◽  
pp. 964-966 ◽  
Author(s):  
Ivan V. Litvinov ◽  
Thomas S. Kupper ◽  
Denis Sasseville
Keyword(s):  
T Cell ◽  
Cell Lymphoma ◽  
T Cell Lymphoma ◽  
Cutaneous T Cell Lymphoma

MicroRNA-150 inhibits tumor invasion and metastasis by targeting the chemokine receptor CCR6, in advanced cutaneous T-cell lymphoma

Blood ◽  
2014 ◽  
Vol 123 (10) ◽  
pp. 1499-1511 ◽  
Author(s):  
Mitsugu Ito ◽  
Kazuaki Teshima ◽  
Sho Ikeda ◽  
Akihiro Kitadate ◽  
Atsushi Watanabe ◽  
...  
Keyword(s):  
T Cell ◽  
Chemokine Receptor ◽  
Tumor Invasion ◽  
Cell Lymphoma ◽  
T Cell Lymphoma ◽  
Cutaneous T Cell Lymphoma ◽  
Autocrine Signaling ◽  
Invasion And Metastasis ◽  
Multiple Organs ◽  
Key Points

Key Points Aberrantly diminished expression of miR-150 allows advanced CTCL to invade multiple organs with upregulation of CCR6. MiR-150 inhibits IL-22-CCL20-CCR6 autocrine signaling in advanced CTCL.

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