Receptor-type tyrosine-protein phosphatase κ directly targets STAT3 activation for tumor suppression in nasal NK/T-cell lymphoma
Keyword(s):
T Cell
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Key Points PTPRK binds to STAT3 and directly dephosphorylates phospho-STAT3 at Tyr705. Loss of PTPRK, located in the deleted 6q region, leads to STAT3 activation and contributes to nasal-type NK/T-cell lymphoma pathogenesis.