scholarly journals Metabolic heterogeneity on baseline 18FDG-PET/CT scan is a predictor of outcome in primary mediastinal B-cell lymphoma

Blood ◽  
2018 ◽  
Vol 132 (2) ◽  
pp. 179-186 ◽  
Author(s):  
Luca Ceriani ◽  
Lisa Milan ◽  
Maurizio Martelli ◽  
Andrés J. M. Ferreri ◽  
Luciano Cascione ◽  
...  
Keyword(s):  
High Risk ◽  
B Cell ◽  
Conventional Therapy ◽  
Cell Lymphoma ◽  
B Cell Lymphoma ◽  
18Fdg Pet ◽  
Pet Ct ◽  
Key Points ◽  
Metabolic Heterogeneity ◽  
Pet Ct Scan

Key Points MH on 18FDG-PET/CT may be a prognostic tool for PMBCL. High TLG combined with high MH at presentation identifies patients at high risk for progression after conventional therapy.

scholarly journals High metabolic heterogeneity on baseline 18FDG-PET/CT scan as a poor prognostic factor for newly diagnosed diffuse large B-cell lymphoma

2020 ◽  
Vol 4 (10) ◽  
pp. 2286-2296
Author(s):  
Hajime Senjo ◽  
Kenji Hirata ◽  
Koh Izumiyama ◽  
Koichiro Minauchi ◽  
Eriko Tsukamoto ◽  
...  
Keyword(s):  
B Cell ◽  
Cell Lymphoma ◽  
B Cell Lymphoma ◽  
Newly Diagnosed ◽  
Large B Cell Lymphoma ◽  
18Fdg Pet ◽  
Pet Ct ◽  
Metabolic Heterogeneity ◽  
Pet Ct Scan ◽  
Large B Cell

Abstract Metabolic heterogeneity (MH) can be measured using 18F-fluorodeoxyglucose (18FDG) positron emission tomography/computed tomography (PET/CT), and it indicates an inhomogeneous tumor microenvironment. High MH has been shown to predict a worse prognosis for primary mediastinal B-cell lymphoma, whereas its prognostic value in diffuse large B-cell lymphoma (DLBCL) remains to be determined. In the current study, we investigated the prognostic values of MH evaluated in newly diagnosed DLBCL. In the training cohort, 86 patients treated with cyclophosphamide, doxorubicin, vincristine, and prednisone–like chemotherapies were divided into low-MH and high-MH groups using receiver operating characteristic analysis. MH was not correlated with metabolic tumor volume of the corresponding lesion, indicating that MH was independent of tumor burden. At 5 years, overall survivals were 89.5% vs 61.2% (P = .0122) and event-free survivals were 73.1% vs 51.1% (P = .0327) in the low- and high-MH groups, respectively. A multivariate Cox-regression analysis showed that MH was an independent predictive factor for overall survival. The adverse prognostic impacts of high MH were confirmed in an independent validation cohort with 64 patients. In conclusion, MH on baseline 18FDG-PET/CT scan predicts treatment outcomes for patients with newly diagnosed DLBCL.

scholarly journals Utility of baseline 18FDG-PET/CT functional parameters in defining prognosis of primary mediastinal (thymic) large B-cell lymphoma

Blood ◽  
2015 ◽  
Vol 126 (8) ◽  
pp. 950-956 ◽  
Author(s):  
Luca Ceriani ◽  
Maurizio Martelli ◽  
Pier Luigi Zinzani ◽  
Andrés J. M. Ferreri ◽  
Barbara Botto ◽  
...  
Keyword(s):  
B Cell ◽  
Metabolic Activity ◽  
Cell Lymphoma ◽  
B Cell Lymphoma ◽  
Powerful Predictor ◽  
Large B Cell Lymphoma ◽  
18Fdg Pet ◽  
Pet Ct ◽  
Key Points ◽  
Large B Cell

Key Points 18FDG PET/CT is a very important staging tool for patients with PMBCL. Metabolic activity defined by TLG on the baseline PET scan is a powerful predictor of PMBCL outcome.

scholarly journals METABOLIC HETEROGENEITY OF BASELINE 18-FDG PET-CT SCAN PREDICTS OUTCOME IN PRIMARY MEDIASTINAL B-CELL LYMPHOMA.

2017 ◽  
Vol 35 ◽  
pp. 60-61 ◽  
Author(s):  
L. Ceriani ◽  
L. Milan ◽  
M. Martelli ◽  
A.J. Ferreri ◽  
A. Di Rocco ◽  
...  
Keyword(s):  
Ct Scan ◽  
B Cell ◽  
Fdg Pet ◽  
Cell Lymphoma ◽  
B Cell Lymphoma ◽  
Pet Ct ◽  
Metabolic Heterogeneity ◽  
Fdg Pet Ct ◽  
Pet Ct Scan

18FDG PET/CT Appearance in Primary Cutaneous Diffuse Large B-Cell Lymphoma, Leg Type

2015 ◽  
Vol 40 (6) ◽  
pp. 506-508 ◽  
Author(s):  
Amin Samarghandi ◽  
Alejandro Ariel Gru ◽  
Mona Natwa ◽  
David W. Barker
Keyword(s):  
B Cell ◽  
Cell Lymphoma ◽  
B Cell Lymphoma ◽  
Large B Cell Lymphoma ◽  
18Fdg Pet ◽  
Pet Ct ◽  
Large B Cell

18FDG PET/CT in Primary Cutaneous Diffuse Large B-Cell Lymphoma Leg Type

2020 ◽  
Vol 45 (5) ◽  
pp. 403-404
Author(s):  
Sébastien Dejust ◽  
David Morland ◽  
Eric Durot ◽  
Florent Grange ◽  
Dimitri Papathanassiou
Keyword(s):  
B Cell ◽  
Cell Lymphoma ◽  
B Cell Lymphoma ◽  
Large B Cell Lymphoma ◽  
18Fdg Pet ◽  
Pet Ct ◽  
Large B Cell

scholarly journals An enhanced International Prognostic Index (NCCN-IPI) for patients with diffuse large B-cell lymphoma treated in the rituximab era

Blood ◽  
2014 ◽  
Vol 123 (6) ◽  
pp. 837-842 ◽  
Author(s):  
Zheng Zhou ◽  
Laurie H. Sehn ◽  
Alfred W. Rademaker ◽  
Leo I. Gordon ◽  
Ann S. LaCasce ◽  
...  
Keyword(s):  
High Risk ◽  
B Cell ◽  
Cell Lymphoma ◽  
International Prognostic Index ◽  
Prognostic Index ◽  
B Cell Lymphoma ◽  
Prognostic Tool ◽  
Large B Cell Lymphoma ◽  
Key Points ◽  
Large B Cell

Key Points The clinically based NCCN-IPI is a robust prognostic tool for the rituximab era that better discriminates low- and high-risk DLBCL patients compared with the IPI. The NCCN-IPI outperforms the IPI by refined categorization of age and LDH, and the identification of disease involvement at specific extranodal sites.

Clinical usefulness of PET/CT in initial staging and response evaluation of primary gastric lymphoma

2009 ◽  
Vol 27 (15_suppl) ◽  
pp. e19541-e19541
Author(s):  
J. Yi ◽  
S. Kim ◽  
S. Lee ◽  
S. Park ◽  
Y. Ko ◽  
...  
Keyword(s):  
Ct Scan ◽  
B Cell ◽  
Cell Lymphoma ◽  
Gastric Lymphoma ◽  
B Cell Lymphoma ◽  
Ct Scans ◽  
Primary Gastric Lymphoma ◽  
Pet Ct ◽  
Pet Ct Scan

e19541 Background: Positron emission tomography (PET)/computed tomography (CT) scan has a well-established role in the management of non-Hodgkin's lymphoma (NHL). However, in case of the primary gastric lymphoma, which is the most frequent extranodal NHL, the role of PET/CT scan is still controversial. Methods: We retrospectively analyzed 42 patients with primary gastric lymphoma who underwent PET/CT scans; 32 patients with diffuse large B-cell lymphoma (DLBCL) and 10 patients with extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) were analyzed. The PET/CT scans were compared with clinicopathologic features and the results of CT and endoscopy. After corresponding treatment, response was evaluated by conventional CT scans or PET/CT scans and endoscopy with biopsy Results: Nine patients were up-staged based on the results of their PET/CT scan compared to CT (7 DLBCL, 2 MALT lymphomas) while six patients were down-staged by the PET/CT scan. The high SUVmax group, defined as SUVmax ≥ median value, was significantly associated with an advanced Lugano stage (P < 0.001). Three patients with DLBCL, who showed an initially high SUVmax, died of disease progression. Although not statistically significant, there was a tendency of inferior outcome in the group with high SUVmax. Among 24 patients for whom follow-up PET/CT scan with endoscopy was performed, 11 patients with ulcerative or mucosal lesions showed residual FDG uptake. All of these gastric lesions were grossly and pathologically benign lesions without evidence of lymphoma cells. Conclusions: PET/CT scan can help staging patients with primary gastric lymphoma, and the maximum SUV has possibility to have prognostic value. However, the residual FDG uptake observed during follow-up should be interpreted cautiously in association with the results of endoscopy and multiple gastric biopsies. No significant financial relationships to disclose.

scholarly journals Primary mediastinal B-cell lymphoma – metabolic and anatomical features in 18FDG-PET/CT and response to therapy

2016 ◽  
Vol 4 ◽  
pp. 297-301
Author(s):  
Anna Kocurek ◽  
Bogdan Małkowski ◽  
Agnieszka Giza ◽  
Wojciech Jurczak
Keyword(s):  
B Cell ◽  
Cell Lymphoma ◽  
B Cell Lymphoma ◽  
Response To Therapy ◽  
Anatomical Features ◽  
18Fdg Pet ◽  
Pet Ct
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