scholarly journals Increased blood clearance rate of indium-111 oxine-labeled autologous CD4+ blood cells in untreated patients with Hodgkin's disease

Blood ◽  
1990 ◽  
Vol 76 (3) ◽  
pp. 583-589 ◽  
Author(s):  
G Grimfors ◽  
G Holm ◽  
H Mellstedt ◽  
PO Schnell ◽  
O Tullgren ◽  
...  
Keyword(s):  
Hodgkin's Disease ◽  
Gamma Camera ◽  
Hodgkin’S Disease ◽  
Gradient Centrifugation ◽  
Blood Clearance ◽  
Cd4 Cells ◽  
Blood Lymphocytes ◽  
Complete Clinical Remission ◽  
Biologic Response ◽  
Indium 111

Abstract Untreated patients with Hodgkin's disease (HD) have a blood T- lymphocytopenia mainly caused by a reduction of the CD4+ subset. Indirect support for a sequestration of T cells in the spleen and tumor- involved lymphoid tissue has accumulated. To test the hypothesis that the blood CD4 T-lymphocytopenia in patients with HD is caused by an altered lymphocyte traffic, 12 untreated HD patients and five in complete clinical remission (CCR) were studied. Blood lymphocytes were collected by leukapheresis and gradient centrifugation, and were further purified by an adherence step. The cells were labeled with indium-111 oxine and reinfused intravenously into the patient. The radioactivity of CD4+ and CD8+ blood lymphocytes separated by immunoabsorption was measured from serial blood samples. CD4+ cells were eliminated more rapidly in untreated patients than patients in CCR. Repeated gamma camera imaging after autotransfusion of indium-111 oxine labeled cells demonstrated an accumulation of radioactivity in tumor-involved tissue of untreated patients. These findings support the concept of an enhanced elimination of CD4+ cells in patients with active HD that may contribute to the observed blood T-lymphocytopenia and may reflect a biologic response to the tumor.

scholarly journals Increased blood clearance rate of indium-111 oxine-labeled autologous CD4+ blood cells in untreated patients with Hodgkin's disease

Blood ◽  
1990 ◽  
Vol 76 (3) ◽  
pp. 583-589
Author(s):  
G Grimfors ◽  
G Holm ◽  
H Mellstedt ◽  
PO Schnell ◽  
O Tullgren ◽  
...  
Keyword(s):  
Hodgkin's Disease ◽  
Gamma Camera ◽  
Hodgkin’S Disease ◽  
Gradient Centrifugation ◽  
Blood Clearance ◽  
Cd4 Cells ◽  
Blood Lymphocytes ◽  
Complete Clinical Remission ◽  
Biologic Response ◽  
Indium 111

Untreated patients with Hodgkin's disease (HD) have a blood T- lymphocytopenia mainly caused by a reduction of the CD4+ subset. Indirect support for a sequestration of T cells in the spleen and tumor- involved lymphoid tissue has accumulated. To test the hypothesis that the blood CD4 T-lymphocytopenia in patients with HD is caused by an altered lymphocyte traffic, 12 untreated HD patients and five in complete clinical remission (CCR) were studied. Blood lymphocytes were collected by leukapheresis and gradient centrifugation, and were further purified by an adherence step. The cells were labeled with indium-111 oxine and reinfused intravenously into the patient. The radioactivity of CD4+ and CD8+ blood lymphocytes separated by immunoabsorption was measured from serial blood samples. CD4+ cells were eliminated more rapidly in untreated patients than patients in CCR. Repeated gamma camera imaging after autotransfusion of indium-111 oxine labeled cells demonstrated an accumulation of radioactivity in tumor-involved tissue of untreated patients. These findings support the concept of an enhanced elimination of CD4+ cells in patients with active HD that may contribute to the observed blood T-lymphocytopenia and may reflect a biologic response to the tumor.

Bone Marrow Scintigraphy in Patients Treated with Chemotherapy and/or Radiotherapy

1977 ◽  
Vol 16 (02) ◽  
pp. 86-88
Author(s):  
V. Foltýnová ◽  
E. Vétrovcová ◽  
E. Tichá ◽  
J. Brousil
Keyword(s):  
Bone Marrow ◽  
Hodgkin's Disease ◽  
Hodgkin’S Disease ◽  
Detailed Knowledge ◽  
General State ◽  
Bone Marrow Scintigraphy ◽  
Indium 111

SummaryBone marrow scintigraphy after the application of indium 111 In was compared with the results of bone marrow puncture in 18 patients with Hodgkin's disease treated with radiotherapy and/or chemotherapy. Agreement was found in 85% of the cases. When the results of bone marrow puncture were compared with the general state of haemopoiesis estimated scintigraphically agreement was found in only 65%. Bone marrow scintigraphy gives a more detailed knowledge of the general state of haemopoiesis and serves as a guide for the control of therapy with cytostatics and/or irradiation.

scholarly journals Fetal Thymic Transplant in Patients With Hodgkin’s Disease

Blood ◽  
1973 ◽  
Vol 41 (5) ◽  
pp. 625-633 ◽  
Author(s):  
Roberto Marcolongo ◽  
Nicola Di Paolo
Keyword(s):  
Peripheral Blood ◽  
Hodgkin's Disease ◽  
Hodgkin’S Disease ◽  
Peripheral Blood Lymphocytes ◽  
Significant Rise ◽  
Immune Functions ◽  
Skin Sensitivity ◽  
Thymic Tissue ◽  
Blood Lymphocytes ◽  
Cellular Immune

Abstract Five patients with Hodgkin’s disease were treated by transplantation of fetal thymic tissue. Clinical and immunologic studies, carried out for over 5 mo thereafter, revealed a prompt improvement in previously defective cellular immune functions, including a significant rise of absolute lymphocytes in the peripheral blood and a normalization of tuberculin skin sensitivity and of the response of peripheral blood lymphocytes to phytohemagglutinin. It is suggested that fetal thymic transplant into patients with Hodgkin’s disease appears at present the best tool of improving their immunologic deficiency.

Autotransfusion of 3H-Cytidine-Labelled Blood Lymphocytes in Patients with Hodgkin’s Disease and Non-Hodgkin Patients

1975 ◽  
Vol 53 (4) ◽  
pp. 206-218 ◽  
Author(s):  
P. Schick ◽  
F. Trepel ◽  
M. Eder ◽  
M. Matzner ◽  
S. Benedek ◽  
...  
Keyword(s):  
Hodgkin's Disease ◽  
Hodgkin’S Disease ◽  
Blood Lymphocytes

Macrophage Electrophoretic Migration Test for Lymphocyte Sensitization to Tumor Antigens.

1974 ◽  
Vol 60 (3) ◽  
pp. 203-210 ◽  
Author(s):  
Sergio Tognella ◽  
Giovanni Mantovani ◽  
Carlo Floris ◽  
Letizia Cengiarotti ◽  
Gennaro S. Del Giacco ◽  
...  
Keyword(s):  
Hodgkin's Disease ◽  
Tumor Antigens ◽  
Hodgkin’S Disease ◽  
Malignant Neoplasm ◽  
Migration Test ◽  
Blood Lymphocytes ◽  
Electrophoretic Migration ◽  
Lymphatic Leukemia ◽  
In Vitro Diagnostic

The macrophage electrophoretic migration test (MEM test) of Field and Caspary was used to study the sensitization to tumor antigens of blood lymphocytes of patients with solid tumor (7), chronic lymphatic leukemia (3), and Hodgkin's disease (8). Our preliminary results are partially in keeping with those of the English authors: blood lymphocytes from some patients with malignant neoplasm seem to be sensitised to crude cancer material irrespective of the type of the tumor from which it derives. The MEM test was negative in the 4 patients with Hodgkin's disease in remission and positive in the 4 patients with active disease. It is believed that further studies are needed before accepting this test as an in vitro diagnostic test for cancer.

scholarly journals Fibrillar Bundles in the Nucleus of Blood Lymphocytes from Leukemic and Nonleukemic Patients

Blood ◽  
1970 ◽  
Vol 35 (2) ◽  
pp. 243-249 ◽  
Author(s):  
STEFANO S. STEFANI ◽  
HIROSHI TONAKI
Keyword(s):  
Chronic Lymphocytic Leukemia ◽  
Hodgkin's Disease ◽  
Hodgkin’S Disease ◽  
Lymphocytic Leukemia ◽  
Blood Lymphocytes ◽  
Normal Individuals

Abstract Fibrillar bundles were found in the nuclei of blood lymphocytes from 15 of 30 normal individuals. Similar fibrils were found in three of 16 cases of chronic lymphocytic leukemia, and in one of eight cases of Hodgkin’s disease. Nuclear bundles when observed in a sample were found only in small numbers. No points of continuity between the nuclear and the cytoplasmic fibrils could be found.

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