scholarly journals KLF1 directly activates expression of the novel fetal globin repressor ZBTB7A/LRF in erythroid cells

2017 ◽  
Vol 1 (11) ◽  
pp. 685-692 ◽  
Author(s):  
Laura J. Norton ◽  
Alister P. W. Funnell ◽  
Jon Burdach ◽  
Beeke Wienert ◽  
Ryo Kurita ◽  
...  
Keyword(s):  
Gene Expression ◽  
Globin Gene ◽  
Regulation Mechanism ◽  
The Novel ◽  
Erythroid Cells ◽  
Key Points ◽  
Specific Regulation ◽  
Globin Gene Expression ◽  
In Erythroid Cells

Key Points KLF1 directly drives expression of ZBTB7A, a key repressor of fetal γ-globin gene expression, in erythroid cells. An erythroid-specific regulation mechanism allows upregulation of a novel ZBTB7A transcript in erythroid cells.

scholarly journals Mi2β-mediated silencing of the fetal γ-globin gene in adult erythroid cells

Blood ◽  
2013 ◽  
Vol 121 (17) ◽  
pp. 3493-3501 ◽  
Author(s):  
Maria Amaya ◽  
Megha Desai ◽  
Merlin Nithya Gnanapragasam ◽  
Shou Zhen Wang ◽  
Sheng Zu Zhu ◽  
...  
Keyword(s):  
Gene Expression ◽  
Major Part ◽  
Globin Gene ◽  
Globin Genes ◽  
Erythroid Cells ◽  
Key Points ◽  
Globin Gene Expression ◽  
Partial Depletion

Key Points Mi2β exerts a major part of its silencing effect on embryonic and fetal globin genes by positively regulating the BCL11A and KLF1 genes. Partial depletion of Mi2β induces increased γ-globin gene expression in primary human erythroid cells without impairing differentiation.

scholarly journals EHMT1 and EHMT2 inhibition induces fetal hemoglobin expression

Blood ◽  
2015 ◽  
Vol 126 (16) ◽  
pp. 1930-1939 ◽  
Author(s):  
Aline Renneville ◽  
Peter Van Galen ◽  
Matthew C. Canver ◽  
Marie McConkey ◽  
John M. Krill-Burger ◽  
...  
Keyword(s):  
Gene Expression ◽  
Gene Locus ◽  
Globin Gene ◽  
Fetal Hemoglobin ◽  
Erythroid Cells ◽  
Adult Human ◽  
Key Points ◽  
Globin Gene Expression

Key Points EHMT1/2 inhibition increases human γ-globin and HbF expression, as well as mouse embryonic β-globin gene expression. EHMT1/2 inhibition decreases H3K9Me2 and increases H3K9Ac at the γ-globin gene locus in adult human erythroid cells.

scholarly journals Antagonistic Regulation of β-Globin Gene Expression by Helix-Loop-Helix Proteins USF and TFII-I

2006 ◽  
Vol 26 (18) ◽  
pp. 6832-6843 ◽  
Author(s):  
Valerie J. Crusselle-Davis ◽  
Karen F. Vieira ◽  
Zhuo Zhou ◽  
Archana Anantharaman ◽  
Jörg Bungert
Keyword(s):  
Gene Expression ◽  
Rna Polymerase Ii ◽  
Control Region ◽  
Adult Stage ◽  
Globin Gene ◽  
Locus Control Region ◽  
Erythroid Cell ◽  
Erythroid Cells ◽  
Globin Gene Expression ◽  
In Erythroid Cells

ABSTRACT The human β-globin genes are expressed in a developmental stage-specific manner in erythroid cells. Gene-proximal cis-regulatory DNA elements and interacting proteins restrict the expression of the genes to the embryonic, fetal, or adult stage of erythropoiesis. In addition, the relative order of the genes with respect to the locus control region contributes to the temporal regulation of the genes. We have previously shown that transcription factors TFII-I and USF interact with the β-globin promoter in erythroid cells. Herein we demonstrate that reducing the activity of USF decreased β-globin gene expression, while diminishing TFII-I activity increased β-globin gene expression in erythroid cell lines. Furthermore, a reduction of USF activity resulted in a significant decrease in acetylated H3, RNA polymerase II, and cofactor recruitment to the locus control region and to the adult β-globin gene. The data suggest that TFII-I and USF regulate chromatin structure accessibility and recruitment of transcription complexes in the β-globin gene locus and play important roles in restricting β-globin gene expression to the adult stage of erythropoiesis.

scholarly journals Calpeptin Increases the Activity of Upstream Stimulatory Factor and Induces High Level Globin Gene Expression in Erythroid Cells

2009 ◽  
Vol 284 (30) ◽  
pp. 20130-20135 ◽  
Author(s):  
I-Ju Lin ◽  
Zhuo Zhou ◽  
Valerie J. Crusselle-Davis ◽  
Babak Moghimi ◽  
Kunjal Gandhi ◽  
...  
Keyword(s):  
Gene Expression ◽  
Globin Gene ◽  
Erythroid Cells ◽  
Upstream Stimulatory Factor ◽  
High Level ◽  
Stimulatory Factor ◽  
Globin Gene Expression ◽  
In Erythroid Cells

Negative regulation of γ-globin gene expression by cyclic AMP-dependent pathway in erythroid cells

2004 ◽  
Vol 32 (3) ◽  
pp. 244-253 ◽  
Author(s):  
Akio Inoue ◽  
Yuichi Kuroyanagi ◽  
Kiminori Terui ◽  
Paolo Moi ◽  
Tohru Ikuta
Keyword(s):  
Gene Expression ◽  
Cyclic Amp ◽  
Globin Gene ◽  
Negative Regulation ◽  
Erythroid Cells ◽  
Dependent Pathway ◽  
Globin Gene Expression ◽  
In Erythroid Cells
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