scholarly journals Assessing small airway impairment in mild-to-moderate smoking asthmatic patients

2016 ◽  
Vol 47 (4) ◽  
pp. 1264-1267 ◽  
Author(s):  
Marco Contoli ◽  
Federico Bellini ◽  
Luca Morandi ◽  
Giacomo Forini ◽  
Stefano Bianchi ◽  
...  
Keyword(s):  
Small Airway ◽  
Asthmatic Patients

scholarly journals Air Trapping Is Associated with Heterozygosity for Alpha-1 Antitrypsin Mutations in Patients with Asthma

Respiration ◽  
2021 ◽  
pp. 1-10
Author(s):  
Marina Aiello ◽  
Marianna Ghirardini ◽  
Laura Marchi ◽  
Annalisa Frizzelli ◽  
Roberta Pisi ◽  
...  
Keyword(s):  
Lung Function ◽  
Serum Concentration ◽  
Forced Expiratory Volume ◽  
Small Airway ◽  
University Hospital ◽  
Air Trapping ◽  
Asthmatic Patients ◽  
Alpha 1 Antitrypsin Deficiency ◽  
Alpha 1 Antitrypsin ◽  
Few Data

<b><i>Background:</i></b> Alpha-1 antitrypsin deficiency (AATD) is a hereditary disorder involving lungs, characterized by low serum concentration of the protein alpha-1 antitrypsin (AAT) also called proteinase inhibitor (PI). Asthma is common in AATD patients, but there are only few data on respiratory function in asthmatic patients with AATD. <b><i>Objectives:</i></b> The aim of the study was to evaluate lung function in asthmatic outpatients with mutation in the <i>SERPINA1</i> gene coding for AAT versus asthmatic subjects without mutation. <b><i>Methods:</i></b> We performed the quantitative analysis of the serum concentration of AAT in 600 outpatients affected by mild to moderate asthma from the University Hospital of Parma, Italy. Fifty-seven of them underwent the genetic analysis subsequently; they were subdivided into mutated and non-mutated subjects. All the mutated patients had a heterozygous genotype, except 1 (PI*SS). We assessed the lung function through a flow-sensing spirometer and the small airway parameters through an impulse oscillometry system. <b><i>Results:</i></b> The values of forced vital capacity (% predicted) and those of the residual volume to total lung capacity ratio (%) were, respectively, lower and higher in patients mutated versus patients without mutation, showing a significantly greater air trapping (<i>p =</i> 0.014 and <i>p =</i> 0.017, respectively). Moreover, patients with mutation in comparison to patients without mutation showed lower forced expiratory volume in 3 s (% predicted) and forced expiratory volume in 6 s (L) spirometric values, reflecting a smaller airways contribution. <b><i>Conclusions:</i></b> In asthmatic patients, heterozygosity for AAT with PI*MZ and PI*MS genotypes was associated with small airway dysfunction and with lung air trapping.

The effect of omalizumab on small airway inflammation as measured by exhaled nitric oxide in moderate-to-severe asthmatic patients

2014 ◽  
Vol 35 (3) ◽  
pp. 241-249 ◽  
Author(s):  
M. Asghar Pasha ◽  
David Jourd'heuil ◽  
Francis Jourd'heuil ◽  
Lori Mahon ◽  
Francisco Romero ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Airway Inflammation ◽  
Exhaled Nitric Oxide ◽  
Small Airway ◽  
Asthmatic Patients ◽  
Severe Asthmatic

scholarly journals Small airway dysfunction in patients with cough variant asthma: a retrospective cohort study

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Jie Gao ◽  
Haigui Wu ◽  
Feng Wu
Keyword(s):  
Retrospective Cohort ◽  
Bronchial Hyperresponsiveness ◽  
Diagnostic Value ◽  
Small Airway ◽  
Small Airways ◽  
Cough Variant Asthma ◽  
Asthmatic Patients ◽  
Cell Test ◽  
Sputum Eosinophils ◽  
The Relationship

Abstract Background Cough variant asthma (CVA) is one of the special populations of asthma. The aim of the study was to compare small airways, the degree of bronchial hyperresponsiveness (BHR) and airway inflammatory subtypes between CVA and classic asthma (CA), and investigate the relationship between these markers to determine the accuracy as indicators of CVA. Methods A total of 825 asthmatic patients participated in the study and 614 were included. 614 patients underwent spirometry and a bronchial challenge with methacholine and 459 patients performed induction sputum cell test. Results The number of CVA patients showed less small airway dysfunction than those of CA patients (p < 0.005). The degree of small airways dysfunction was higher in the CA group compared with the CVA group (p < 0.001). Small airways dysfunction was severer in the eosinophilic airway inflammatory subtype compared with other subtypes (p < 0.05).The area under curve of MMEF, FEF50 and FEF75 (% predicted) was 0.615, 0.621, 0.606, respectively. 0.17mcg of PD20 and 4.7% of sputum eosinophils was the best diagnostic value for CVA with an AUC of 0.582 and 0.575 (p = 0.001 and p = 0.005, respectively). Conclusions The eosinophilic airway inflammatory subtype may be increased small airway dysfunction. The value of small airways, BHR and induction sputum cells in CVA prediction, which reflected significant, but not enough to be clinically useful.

Small airway dysfunction by impulse oscillometry in asthmatic patients with normal forced expiratory volume in the 1st second values

2013 ◽  
Vol 34 (1) ◽  
pp. 14-20 ◽  
Author(s):  
Roberta Pisi ◽  
Panagiota Tzani ◽  
Marina Aiello ◽  
Enrico Martinelli ◽  
Emilio Marangio ◽  
...  
Keyword(s):  
Forced Expiratory Volume ◽  
Small Airway ◽  
Impulse Oscillometry ◽  
Asthmatic Patients

Small airway impairment in severe asthmatic patients

2018 ◽  
Author(s):  
Marco Contoli ◽  
Luca Morandi ◽  
Federico Bellini ◽  
Sara Soave ◽  
Giacomo Forini ◽  
...  
Keyword(s):  
Small Airway ◽  
Asthmatic Patients ◽  
Severe Asthmatic

scholarly journals Club cell secretory protein serum concentration is a surrogate marker of small-airway involvement in asthmatic patients

2017 ◽  
Vol 140 (2) ◽  
pp. 581-584 ◽  
Author(s):  
Sebastien Bommart ◽  
Grégory Marin ◽  
Nicolas Molinari ◽  
Lucie Knabe ◽  
Aurélie Petit ◽  
...  
Keyword(s):  
Serum Concentration ◽  
Surrogate Marker ◽  
Secretory Protein ◽  
Small Airway ◽  
Asthmatic Patients ◽  
Club Cell ◽  
Protein Serum

Small airways and bronchial hyper-responsiveness in cough-variant asthma

2020 ◽  
Author(s):  
jie gao ◽  
Feng Wu ◽  
Xing Yang ◽  
Sifang Wu
Keyword(s):  
Area Under Curve ◽  
Pulmonary Function Tests ◽  
Diagnostic Value ◽  
Small Airway ◽  
Small Airways ◽  
Cough Variant Asthma ◽  
Asthmatic Patients ◽  
Bronchial Hyper Responsiveness ◽  
Positive Correlations ◽  
The Relationship

Abstract Background Cough variant asthma (CVA) is one of the special populations of asthma. The study was to compare spirometric parameters of small airways and the degree of bronchial hyper-responsiveness (BHR) between CVA and classic asthma (CA), and examine the relationship between BHR and small airways to determine the accuracy of these markers as indicators of CVA. Methods A total of 825 asthmatic patients were screened for the study and 614 were included. All patients performed spirometry and underwent a bronchial challenge with methacholine. It has been estimated that less than 65% of the small airways must be obstructed before changes can be detected using routine pulmonary function tests. Results CVA patients showed less small airway dysfunction (< 65%) than those of CA patients with MMEF% predicted (70% vs 80.91%, p = 0.002) and FEF50% predicted (62.71% vs 73.5%, p = 0.004). The function of small airways was higher in the CVA group compared with the CA group (p < 0.001). CVA patients had a mild BHR (p = 0.005). Significant positive correlations were observed between PD20 and MMEF% predicted (r = 0.282, p < 0.001), FEF50% predicted (r = 0.2522, p < 0.001), FEF75% predicted (r = 0.2504, p < 0.001) in patients with CVA. The area under curve of MMEF, FEF50 and FEF75 (% predicted) was 0.615, 0.621, 0.606, respectively. 0.17mcg of PD20 was the best diagnostic value for CVA with an AUC of 0.582 (p = 0.001). Conclusions Small airway dysfunction is milder showed in CVA. The value of BHR combined with small airways in CVA prediction, which reflected significant, but not enough to be clinically useful.

Sign in / Sign up

Export Citation Format

Share Document