The impact of changing to the GLI reference equations on transfer factor results in children referred from a Haematology/Oncology service.

2018 ◽  
Author(s):  
Paul Burns ◽  
James Paton
Keyword(s):  
Transfer Factor ◽  
Oncology Service ◽  
Reference Equations ◽  
The Impact

scholarly journals The impact of changing to the Global Lung Function Initiative reference equations for transfer factor in paediatrics

2020 ◽  
pp. 00412-2020
Author(s):  
Paul D. Burns ◽  
James Y. Paton
Keyword(s):  
Carbon Monoxide ◽  
Lung Function ◽  
Paediatric Patient ◽  
Transfer Factor ◽  
Reference Equations ◽  
The Difference ◽  
Predicted Values ◽  
Age Range ◽  
The Impact ◽  
Interpretation Of Results

The Global Lung Function Initiative (GLI) all age reference equations for carbon monoxide transfer factor were published in 2017 and endorsed by the ERS/ATS. In order to understand the impact of these new reference equations on the interpretation of results in children referred from haematology and oncology paediatric services, we retrospectively analysed transfer factor results from any paediatric patient referred from haematology oncology in the period 2010–2018. We examined TLCO, KCO and VA from 241 children (age range; 7–18, 130 male). The predicted values from Rosenthal and GLI were plotted against height. The difference in interpretation of results was analysed by looking at the percentage of patients <LLN for each parameter. Overall, the Rosenthal predicted values for TLCO were higher than GLI. Predicted KCO using Rosenthal was higher in all observations. In contrast, the Rosenthal predicted VA was generally lower than the GLI value. The GLI predicted values for transfer factor show considerable differences compared with currently used paediatric UK reference values, differences that will have a significant impact on interpretation of results.

Effect of corrected GLI reference equations on carbon monoxide transfer factor interpretation

2021 ◽  
pp. 2004459
Author(s):  
Warren R. Ruehland ◽  
Celia J. Lanteri ◽  
Pam Matsas ◽  
Danny J. Brazzale
Keyword(s):  
Carbon Monoxide ◽  
Transfer Factor ◽  
Reference Equations

scholarly journals Stitching and switching: the impact of discontinuous lung function reference equations: Figure 1–

2012 ◽  
Vol 39 (5) ◽  
pp. 1256-1257 ◽  
Author(s):  
Jane Kirkby ◽  
Paul Aurora ◽  
Helen Spencer ◽  
Stephanie Rees ◽  
Samantha Sonnappa ◽  
...  
Keyword(s):  
Lung Function ◽  
Reference Equations ◽  
The Impact

Global lung function initiative: Reference equations for the transfer factor for carbon monoxide (TLCO)

2016 ◽  
Author(s):  
Sanja Stanojevic ◽  
Brian Grham ◽  
Brendan Cooper ◽  
Bruce Thompson ◽  
Kim Carter ◽  
...  
Keyword(s):  
Carbon Monoxide ◽  
Lung Function ◽  
Transfer Factor ◽  
Reference Equations

Introduction of computerized provider order entry (CPOE) and time impact in an inpatient hematology/oncology service: Serial time and motion studies

2009 ◽  
Vol 27 (15_suppl) ◽  
pp. e17507-e17507
Author(s):  
D. A. Hanauer ◽  
R. W. Beasley ◽  
J. Schumacher ◽  
M. G. Duck ◽  
D. W. Blayney
Keyword(s):  
Patient Care ◽  
Physician Assistants ◽  
House Staff ◽  
Direct Patient Care ◽  
Care Providers ◽  
Order Entry ◽  
Time And Motion ◽  
Oncology Service ◽  
The Impact ◽  
Productive Time

e17507 Background: The impact of CPOE on inpatient hematology/oncology care is not well studied. CPOE has many benefits, but concerns exist about increased time required to enter electronic orders compared to handwritten orders. We hypothesized that CPOE would require more order-related time from caregivers, and reduce the amount of time for direct patient care. Methods: Physician assistants (PAs) enter all patient orders (except those for chemotherapy) and are the dedicated and exclusive care providers on this non-house staff service at the main Hospital of the University of Michigan Health System. We chose the PA service for observation as we could eliminate potential biases introduced by rotating house staff we observed in earlier studies. PAs were directly observed at -1, +3 and +8 months post implementation of a CPOE system (Sunrise Clinical Manager, Eclypsis, Atlanta GA). Dedicated observers used a data entry tool with a modified database (available on the Health IT Tools section at healthit.ahrq.gov) on a tablet computer. For analysis, the 60 individual activities were grouped into 6 major categories, as well as an ordering category. We observed the same three PAs for 82.5 hours pre-CPOE, for 75.0 hours at 3 months post and for 70.5 hours 8 months post. Productive time was all non-personal and non-administrative time. The faculty entered chemotherapy orders and supervised the PAs, but were not studied. Results: Overall time for order-related activities was unchanged during the three observation periods, requiring 10.3, 10.6 and 11.4% of productive time, respectively. Time spent on direct patient care (as a percentage of productive time) was also unchanged once CPOE was implemented (50.7% pre vs. 49.8% and 47.8% post). Conclusions: We could not detect differences in order-entry time by well-trained PAs using standardized order sets before and after CPOE implementation on an inpatient hematology/oncology service. The decision to adopt CPOE should not be based on the hypothesis that there will be less (or more) time spent on order entry tasks. No significant financial relationships to disclose.

scholarly journals Vaccinal prevention of nodular dermatitis in Hereford cattle (clinical and immunological implications)

2020 ◽  
Vol 222 ◽  
pp. 02038
Author(s):  
P.V. Burkov ◽  
P.N. Scherbakov ◽  
S.R. Slobodyansky
Keyword(s):  
Blood Serum ◽  
Transfer Factor ◽  
Negative Impact ◽  
Medicinal Preparation ◽  
Biological Origin ◽  
Combined Application ◽  
Hereford Cattle ◽  
Lower Temperature ◽  
Animal Vaccination ◽  
The Impact

Animal vaccination is the principal method of preventing nodular dermatitis in cattle. Objective: to analyze the impact of using a specific transfer factor in vaccination of Hereford cattle against nodular dermatitis on the development of immunity and indices of animal homeostasis. Application of the transfer factor and the vitamin preparation Asidivit in the vaccination of animals against nodular dermatitis has reduced the reactogenicity of the vaccine in the form of a lower temperature reaction to the medicinal preparation of biological origin. The combined application of the immunoamplifier and Asidivit decreased the negative impact of vaccination on the liver of animals. The greatest quantitative decrease in bilirubin in the blood serum by 14% was observed. It made it possible to achieve a significant increase in antibodies in the blood serum by 72.4% compared to the initial analysis and an increase in the number of antibody-positive animals up to 80%.

scholarly journals Effects of adopting the Global Lung Function Initiative 2017 reference equations on the interpretation of carbon monoxide transfer factor

2020 ◽  
Vol 55 (5) ◽  
pp. 1901905
Author(s):  
Danny J. Brazzale ◽  
Leigh M. Seccombe ◽  
Liam Welsh ◽  
Celia J. Lanteri ◽  
Claude S. Farah ◽  
...  
Keyword(s):  
Carbon Monoxide ◽  
Lung Function ◽  
Transfer Factor ◽  
Teaching Hospitals ◽  
Younger Adults ◽  
Adult Females ◽  
Reference Set ◽  
Reference Equations ◽  
Lower Limit Of Normal ◽  
A Current

The recently published Global Lung Function Initiative (GLI) carbon monoxide transfer factor (TLCO) reference equations provide an opportunity to adopt a current, all-age, widely applicable reference set. The aim of this study was to document the effect of changing to GLI from commonly utilised reference equations on the interpretation of TLCO results.33 863 TLCO results (48% female, 88% Caucasian, n=930 aged <18 years) from clinical pulmonary function laboratories within three Australian teaching hospitals were analysed. The lower limit of normal (LLN) and proportion of patients with a TLCO below this value were calculated using GLI and other commonly used reference equations.The average TLCO LLN for GLI was similar or lower than the other equations, with the largest difference seen for Crapo equations (median: −1.25, IQR: −1.64, −0.86 mmol·min−1·kPa−1). These differences resulted in altered rates of reduced TLCO for GLI particularly for adults (+1.9% versus Miller to −27.6% versus Crapo), more so than for children (−0.8% versus Kim to −14.2% versus Cotes). For adults, the highest raw agreement for GLI was with Miller equations (94.7%), while for children it was with Kim equations (98.1%). Results were reclassified from abnormal to normal more frequently for younger adults, and for adult females, particularly when moving from Roca to GLI equations (30% of females versus 16% of males).The adoption of GLI TLCO reference equations in adults will result in altered interpretation depending on the equations previously used and to a greater extent in adult females. The effect on interpretation in children is less significant.

19: The impact of an acute oncology service on new lung cancer diagnoses

Lung Cancer ◽  
2015 ◽  
Vol 87 ◽  
pp. S8
Author(s):  
H.S. Walter ◽  
A. Law ◽  
C. Bunn ◽  
R. Nicoll ◽  
T. Sridhar ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Oncology Service ◽  
The Impact

scholarly journals Official ERS technical standard: Global Lung Function Initiative reference values for static lung volumes in individuals of European ancestry

2021 ◽  
Vol 57 (3) ◽  
pp. 2000289
Author(s):  
Graham L. Hall ◽  
Nicole Filipow ◽  
Gregg Ruppel ◽  
Tolu Okitika ◽  
Bruce Thompson ◽  
...  
Keyword(s):  
Lung Function ◽  
Lung Volume ◽  
Additive Models ◽  
European Ancestry ◽  
Reference Ranges ◽  
Body Plethysmography ◽  
Lung Volumes ◽  
Reference Equations ◽  
Gas Dilution ◽  
The Impact

BackgroundMeasurement of lung volumes across the life course is critical to the diagnosis and management of lung disease. The aim of the study was to use the Global Lung Function Initiative methodology to develop all-age multi-ethnic reference equations for lung volume indices determined using body plethysmography and gas dilution techniques.MethodsStatic lung volume data from body plethysmography and gas dilution techniques from individual, healthy participants were collated. Reference equations were derived using the LMS (lambda-mu-sigma) method and the generalised additive models of location shape and scale programme in R. The impact of measurement technique, equipment type and being overweight or obese on the derived lung volume reference ranges was assessed.ResultsData from 17 centres were submitted and reference equations were derived from 7190 observations from participants of European ancestry between the ages of 5 and 80 years. Data from non-European ancestry populations were insufficient to develop multi-ethnic equations. Measurements of functional residual capacity (FRC) collected using plethysmography and dilution techniques showed physiologically insignificant differences and were combined. Sex-specific reference equations including height and age were developed for total lung capacity (TLC), FRC, residual volume (RV), inspiratory capacity, vital capacity, expiratory reserve volume and RV/TLC. The derived equations were similar to previously published equations for FRC and TLC, with closer agreement during childhood and adolescence than in adulthood.ConclusionsGlobal Lung Function Initiative reference equations for lung volumes provide a generalisable standard for reporting and interpretation of lung volumes measurements in individuals of European ancestry.

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