Effects of Diltiazem on pulmonary hemodynamics and right heart function in patients with chronic obstructive pulmonary disease (COPD)>

2020 ◽  
Author(s):  
Valentin Calancea ◽  
Constantin Martiniuc ◽  
Ecaterina Luca ◽  
Nicolae Bodrug ◽  
Doina Barba ◽  
...  
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Disease ◽  
Heart Function ◽  
Chronic Obstructive ◽  
Right Heart ◽  
Pulmonary Hemodynamics ◽  
Obstructive Pulmonary Disease ◽  
Right Heart Function

scholarly journals Echocardiographic right heart study in patients with chronic obstructive pulmonary disease

2017 ◽  
Vol 14 (2) ◽  
pp. 9-12
Author(s):  
Anish Hirachan ◽  
Arun Maskey ◽  
Ram Kishore Shah ◽  
Bishal KC ◽  
Miqdhaadh Shareef ◽  
...  
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Hypertension ◽  
Pulmonary Disease ◽  
Heart Function ◽  
Chronic Obstructive ◽  
Rapid Progression ◽  
Right Heart ◽  
Obstructive Pulmonary Disease ◽  
Copd Patients ◽  
The Right

Background and Aims: Chronic obstructive pulmonary disease (COPD) is highly prevalent in the Nepalese population. It is associated with significant extrapulmonary effects among which cardiovascular complications are most common. Echocardiography evaluation mainly focused on effects on the right heart function is a salient tool to evaluate the presence of degree of pulmonary hypertension and also identify those group of patients who need more early aggressive therapy for the underling lung disease . We aimed to prospectively study the patients with diagnosed COPD with echocardiogram for evaluating the right heart.Methods: An observational, cross sectional study was done on 50 patients with COPD who were admitted at Bir Hospital and underwent echocardiographic evaluation from Dec 2015 –Dec 2016. All echocardiogaphic parameters focused on right heart and its function were assessed .Results: Out of total 50 COPD patients studied, majority of them were female (32 patients. 64%). The mean age group of the studied patients was 60.9 ±11.4 years. Pulmonary hypertension defined as sPAP>30 mmHg was evident in all of the patients ; with 30 patients (60% ), 14 (28 %) and 6(12 %) patients having severe, moderate and mild pulmonary hypertension respectively. RV dysfunction was evident with reduced average TAPSE values (1.59± 0.38 cm) and elevated RIMP values (0.58±0.16).Conclusion: Majority of COPD patients had evidence of pulmonary hypertension. Echocardiogram can be a helpful tool to assess early changes on the right heart size and function in patients with COPD and also monitor these patients for rapid progression of the illness.Nepalese Heart Journal 2017; Vol 14(2), 9-12

scholarly journals Pulmonary hemodynamics in chronic obstructive pulmonary disease (Three decades of study in the Republic of Moldova)

2021 ◽  
Vol 69 (1) ◽  
Author(s):  
Valentin Calancea ◽  
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Hypertension ◽  
Pulmonary Disease ◽  
Right Heart Failure ◽  
Chronic Obstructive ◽  
Right Heart ◽  
Pulmonary Hemodynamics ◽  
Obstructive Pulmonary Disease ◽  
Pulmonary Hemodynamic ◽  
The Republic

Chronic obstructive pulmonary disease (COPD) is one of the leading causes of morbidity and mortality worldwide. COPD is frequently associated with comorbidities, the most common complication being pulmonary hypertension and subsequent right heart failure. The prevalence of pulmonary hypertension and the pathophysiological processes of its installation in patients with COPD remain insufficiently studied, although it is known that its share increases with the severity of COPD, and its rate has been reported ranging from 20% to 90%. in the article, the author summarizes the notorious international discoveries and local contributions in this field, elucidating the opportunities, challenges and perspectives of studying the problem. Multiple investigations conducted in the last three decades by local researchers have deepened the knowledge of the pathophysiology, clinic, diagnosis, treatment and prophylaxis of pulmonary hemodynamic and cardiac function disorders in patients with COPD. Further investigations in this area are needed.

scholarly journals Multi-scale computational models of the airways to unravel the pathophysiological mechanisms in asthma and chronic obstructive pulmonary disease (AirPROM)

2013 ◽  
Vol 3 (2) ◽  
pp. 20120057 ◽  
Author(s):  
K. S. Burrowes ◽  
J. De Backer ◽  
R. Smallwood ◽  
P. J. Sterk ◽  
I. Gut ◽  
...  
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Disease ◽  
Heart Function ◽  
Scale Model ◽  
Patient Specific ◽  
Chronic Obstructive ◽  
Disease Heterogeneity ◽  
Obstructive Pulmonary Disease ◽  
Pathophysiological Mechanisms ◽  
Multi Scale

The respiratory system comprises several scales of biological complexity: the genes, cells and tissues that work in concert to generate resultant function. Malfunctions of the structure or function of components at any spatial scale can result in diseases, to the detriment of gas exchange, right heart function and patient quality of life. Vast amounts of data emerge from studies across each of the biological scales; however, the question remains: how can we integrate and interpret these data in a meaningful way? Respiratory disease presents a huge health and economic burden, with the diseases asthma and chronic obstructive pulmonary disease (COPD) affecting over 500 million people worldwide. Current therapies are inadequate owing to our incomplete understanding of the disease pathophysiology and our lack of recognition of the enormous disease heterogeneity: we need to characterize this heterogeneity on a patient-specific basis to advance healthcare. In an effort to achieve this goal, the AirPROM consortium ( Air way disease Pr edicting O utcomes through patient-specific computational M odelling) brings together a multi-disciplinary team and a wealth of clinical data. Together we are developing an integrated multi-scale model of the airways in order to unravel the complex pathophysiological mechanisms occurring in the diseases asthma and COPD.

Sign in / Sign up

Export Citation Format

Share Document