scholarly journals Pulmonary thrombo-embolism in pregnancy: diagnosis and management

Breathe ◽  
2015 ◽  
Vol 11 (4) ◽  
pp. 282-289 ◽  
Author(s):  
Louise E. Simcox ◽  
Laura Ormesher ◽  
Clare Tower ◽  
Ian A Greer
Keyword(s):  
Molecular Weight ◽  
Venous Thromboembolism ◽  
Low Molecular Weight Heparin ◽  
Pulmonary Thromboembolism ◽  
Total Duration ◽  
Bleeding Risk ◽  
Low Molecular Weight ◽  
List Type ◽  
Diagnosis And Management ◽  
In Pregnancy

Key pointsVenous thromboembolism (VTE) in pregnancy remains a leading cause of direct maternal mortality in the developed world and identifiable risk factors are increasing in incidence.VTE is approximately 10-times more common in the pregnant population (compared with non-pregnant women) with an incidence of 1 in 1000 and the highest risk in the postnatal period.If pulmonary imaging is required, ventilation perfusion scanning is usually the preferred initial test to detect pulmonary embolism within pregnancy. Treatment should be commenced on clinical suspicion and not be withheld until an objective diagnosis is obtained.The mainstay of treatment for pulmonary thromboembolism in pregnancy is anticoagulation with low molecular weight heparin for a minimum of 3 months in total duration and until at least 6 weeks postnatal. Low molecular weight heparin is safe, effective and has a low associated bleeding risk.Educational aimsTo inform readers about the current guidance for diagnosis and management of pulmonary thromboembolism in pregnancy.To highlight the risks of venous thromboembolism during pregnancy.To introduce the issues surrounding management of pulmonary thromboembolism around labour and delivery

scholarly journals Thromboembolism and antithrombotic management in pregnancy

2011 ◽  
Vol 152 (21) ◽  
pp. 815-821 ◽  
Author(s):  
Attila Pajor
Keyword(s):  
Risk Factors ◽  
Molecular Weight ◽  
Venous Thromboembolism ◽  
Low Molecular Weight Heparin ◽  
Oral Anticoagulants ◽  
Individual Risk ◽  
Low Molecular Weight ◽  
Pregnancy And Delivery ◽  
Individual Risk Factors ◽  
In Pregnancy

Venous thromboembolism occurs approximately in 1 of 1000 pregnancies. It is one of the leading causes of maternal mortality. Physiologic changes associated with pregnancy and delivery favor for developing venous thromboembolism, and there are individual risk factors, too, contributing to its manifestation. The most frequent risk factors of venous thromboembolism developing during pregnancy are the previous venous thromboembolism and the thrombophilias, furthermore, some other diseases and some unique complications of pregnancy and delivery. Beyond mechanical prevention only heparin preparations can be used for preventing and treating venous thromboembolism in pregnancy and among them the low-molecular-weight heparins are preferred for applying. Dosage of low-molecular-weight heparin preparations is determined by the type and strength of thrombophilia. For treatment of venous thromboembolism presented during pregnancy subcutaneous 100 IU/kg low-molecular-weight heparin is generally used at every 12 hours. Postpartum the oral anticoagulants can be safely applied, too. Orv. Hetil., 2011, 152, 815–821.

scholarly journals Thrombosis in pregnancy: updates in diagnosis and management

Hematology ◽  
2012 ◽  
Vol 2012 (1) ◽  
pp. 203-207 ◽  
Author(s):  
Ian A. Greer
Keyword(s):  
Venous Thromboembolism ◽  
Low Molecular Weight Heparin ◽  
Pulmonary Thromboembolism ◽  
Diagnostic Technique ◽  
Pulmonary Angiography ◽  
Low Molecular Weight ◽  
Prompt Treatment ◽  
Lung Scan ◽  
Acute Venous Thromboembolism ◽  
In Pregnancy

Abstract Acute venous thromboembolism poses significant problems in pregnancy, a time when objective diagnosis and prompt treatment are essential. Events can occur at any stage in pregnancy, but the period of greatest risk is in the weeks after delivery. Ultrasound venography remains the diagnostic technique of choice for deep venous thrombosis. For pulmonary thromboembolism, ventilation perfusion lung scan is usually preferred more than computerized tomography pulmonary angiography because of the lower maternal radiation dose and the lower prevalence of coexisting pulmonary problems. Low-molecular-weight heparin is the agent of choice for treatment of venous thromboembolism in pregnancy, and treatment should be provided for a minimum of 3 months and for at least 6 weeks after delivery. New anticoagulant agents such as dabigatran, rivaroxaban, or apixaban are not recommended for use in pregnancy.

Low Molecular Weight Heparin for the Treatment of Venous Thromboembolism in Pregnancy: A Case Series

2003 ◽  
Vol 58 (3) ◽  
pp. 153-155
Author(s):  
V. A. Rodie ◽  
A. J. Thomson ◽  
F. M. Stewart ◽  
A. J. Quinn ◽  
I. D. Walker ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Venous Thromboembolism ◽  
Low Molecular Weight Heparin ◽  
Case Series ◽  
Low Molecular Weight ◽  
In Pregnancy
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