Multiple sclerosis (MS) is dened as one chronic disease of central nervous system with
neurodegenerative and inammatory components, where most of the patients shown a relapsingremitting course dened by the acute inception of focal neurologic decits and consistent focal inammatory changes visible
on MRI. The causal factor of this complicated autoimmune and neurodegenerative disease is still unknown. Mitochondrial
dysfunction is the key contributor to the neurodegenerative process of this disease. The current review signies the possible
potential role of mitochondria in MS and the different dietary approach as a disease modier with the special emphasis on
mitochondrial function and neurodegenerations.Research regarding therapeutic implementation of different diet in MS is
advancing day by day; but currently remains with limited data. Few studies have been intended with meticulously collected
observations, and the very few clinical trials that have been executed with insufcient sample size or length to adequately
assess efcacy. More epidemiological and observational studies on dietary implementations were required
