scholarly journals Acquired homotypic and heterotypic immunity against oculogenital Chlamydia trachomatis serovars following female genital tract infection in mice

2005 ◽  
Vol 5 (1) ◽  
Author(s):  
Joseph M Lyons ◽  
Servaas A Morré ◽  
Lucy P Airo-Brown ◽  
A Salvador Peña ◽  
James I Ito
Keyword(s):  
Chlamydia Trachomatis ◽  
Tract Infection ◽  
Genital Tract ◽  
Female Genital Tract ◽  
Genital Tract Infection ◽  
Female Genital

scholarly journals Human Female Genital Tract Infection by the Obligate Intracellular Bacterium Chlamydia trachomatis Elicits Robust Type 2 Immunity

PLoS ONE ◽  
2013 ◽  
Vol 8 (3) ◽  
pp. e58565 ◽  
Author(s):  
Rodolfo D. Vicetti Miguel ◽  
Stephen A. K. Harvey ◽  
William A. LaFramboise ◽  
Seth D. Reighard ◽  
Dean B. Matthews ◽  
...  
Keyword(s):  
Chlamydia Trachomatis ◽  
Tract Infection ◽  
Genital Tract ◽  
Female Genital Tract ◽  
Obligate Intracellular Bacterium ◽  
Human Female ◽  
Genital Tract Infection ◽  
Obligate Intracellular ◽  
Female Genital

scholarly journals Role of Gamma Interferon in Controlling Murine Chlamydial Genital Tract Infection

1999 ◽  
Vol 67 (10) ◽  
pp. 5518-5521 ◽  
Author(s):  
James I. Ito ◽  
Joseph M. Lyons
Keyword(s):  
Chlamydia Trachomatis ◽  
Tract Infection ◽  
Genital Tract ◽  
Chlamydial Infection ◽  
Female Genital Tract ◽  
Gamma Interferon ◽  
Genital Tract Infection ◽  
Ifn Γ ◽  
Female Genital

ABSTRACT Earlier investigations have not shown an important role for gamma interferon (IFN-γ) in the early clearance of chlamydial infection from the murine female genital tract. In a model using a human genital isolate of Chlamydia trachomatis in IFN-γ and IFN-γ receptor knockout mice, we were able to demonstrate a major role for IFN-γ in mediating control of infection throughout the course of infection.

scholarly journals Efficacy of an Immune Modulator in ExperimentalChlamydia trachomatisInfection of the Female Genital Tract

2006 ◽  
Vol 2006 ◽  
pp. 1-6
Author(s):  
Joseph M. Lyons ◽  
James I. Ito ◽  
Servaas A. Morré
Keyword(s):  
Tract Infection ◽  
Murine Model ◽  
Genital Tract ◽  
Female Genital Tract ◽  
Response Modifier ◽  
Genital Tract Infection ◽  
Prophylactic Dose ◽  
Duration Of Infection ◽  
Immune Response Modifier ◽  
Female Genital

Objective.The aim of this study was to determine if vaginal application of the immune response modifier imiquimod (Aldara cream, 3M Pharmaceuticals, St Paul, Minn) would alter the course and/or outcome of female genital tract infection with a human isolate ofChlamydia trachomatisin a murine model.Methods.Groups of CF-1 mice were treated with Aldara on three different schedules: (1) ongoing beginning 5 days prior to and continuing through day 5 of infection; (2) a single prophylactic dose 2 hours prior to infection; and (3) therapeutic from day 4 to day 14 of infection. Mice were infected vaginally with a serovar D strain ofC trachomatis, and monitored by culture to determine the level of shedding and duration of infection.Results.We observed a significant reduction in both duration of infection and the level of shedding during the acute phase in mice treated on an ongoing basis commencing 5 days prior to infection. There was no effect with respect to the other regimens.Conclusion.These results demonstrate that ongoing Aldara treatment has efficacy and may enhance local innate immunity which reduces the duration of subsequent infection with human isolates ofC trachomatisin a murine model of female genital tract infection.

scholarly journals Adhesion Molecules Associated with Female Genital Tract Infection

PLoS ONE ◽  
2016 ◽  
Vol 11 (6) ◽  
pp. e0156605 ◽  
Author(s):  
Jamal Qualai ◽  
Jon Cantero ◽  
Lin-Xi Li ◽  
José Manuel Carrascosa ◽  
Eduard Cabré ◽  
...  
Keyword(s):  
Tract Infection ◽  
Adhesion Molecules ◽  
Genital Tract ◽  
Female Genital Tract ◽  
Genital Tract Infection ◽  
Female Genital

Individual immunity and susceptibility to female genital tract infection

2000 ◽  
Vol 183 (1) ◽  
pp. 252-256 ◽  
Author(s):  
S WITKIN ◽  
I LINHARES ◽  
P GIRALDO ◽  
J JEREMIAS ◽  
W LEDGER
Keyword(s):  
Tract Infection ◽  
Genital Tract ◽  
Female Genital Tract ◽  
Genital Tract Infection ◽  
Individual Immunity ◽  
Female Genital

scholarly journals Animal Models for Studying Female Genital Tract Infection with Chlamydia trachomatis

2013 ◽  
Vol 81 (9) ◽  
pp. 3060-3067 ◽  
Author(s):  
Evelien De Clercq ◽  
Isabelle Kalmar ◽  
Daisy Vanrompay
Keyword(s):  
Chlamydia Trachomatis ◽  
Animal Models ◽  
Genital Tract ◽  
Transmitted Disease ◽  
Female Genital Tract ◽  
Genital Tract Infection ◽  
Content Type ◽  
Genital Tract Infections ◽  
Tract Infections ◽  
Female Genital

ABSTRACTChlamydia trachomatisis a Gram-negative obligate intracellular bacterial pathogen. It is the leading cause of bacterial sexually transmitted disease in the world, with more than 100 million new cases of genital tract infections withC. trachomatisoccurring each year. Animal models are indispensable for the study ofC. trachomatisinfections and the development and evaluation of candidate vaccines. In this paper, the most commonly used animal models to study female genital tract infections withC. trachomatiswill be reviewed, namely, the mouse, guinea pig, and nonhuman primate models. Additionally, we will focus on the more recently developed pig model.

Individual immunity and susceptibility to female genital tract infection

2000 ◽  
Vol 183 (1) ◽  
pp. 252-256 ◽  
Author(s):  
Steven S. Witkin ◽  
Iara Linhares ◽  
Paulo Giraldo ◽  
Jan Jeremias ◽  
William J. Ledger
Keyword(s):  
Tract Infection ◽  
Genital Tract ◽  
Female Genital Tract ◽  
Genital Tract Infection ◽  
Individual Immunity ◽  
Female Genital
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