scholarly journals Activating transcription factor-3 (ATF3) functions as a tumor suppressor in colon cancer and is up-regulated upon heat-shock protein 90 (Hsp90) inhibition

BMC Cancer ◽  
2010 ◽  
Vol 10 (1) ◽  
Author(s):  
Christina Hackl ◽  
Sven A Lang ◽  
Christian Moser ◽  
Akira Mori ◽  
Stefan Fichtner-Feigl ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Transcription Factor ◽  
Heat Shock ◽  
Tumor Suppressor ◽  
Heat Shock Protein ◽  
Heat Shock Protein 90 ◽  
Activating Transcription Factor 3 ◽  
Hsp90 Inhibition ◽  
Activating Transcription Factor ◽  
Transcription Factor 3

Activating transcription factor 3 promotes colon cancer metastasis

Tumor Biology ◽  
2014 ◽  
Vol 35 (8) ◽  
pp. 8329-8334 ◽  
Author(s):  
Zhi-Yong Wu ◽  
Zheng-mao Wei ◽  
Sheng-Jie Sun ◽  
Jing Yuan ◽  
Shun-Chang Jiao
Keyword(s):  
Colon Cancer ◽  
Transcription Factor ◽  
Cancer Metastasis ◽  
Activating Transcription Factor 3 ◽  
Colon Cancer Metastasis ◽  
Activating Transcription Factor ◽  
Transcription Factor 3

scholarly journals Heat Shock Transcription Factor 1 Inhibits Expression of IL-6 through Activating Transcription Factor 3

2009 ◽  
Vol 184 (2) ◽  
pp. 1041-1048 ◽  
Author(s):  
Ryosuke Takii ◽  
Sachiye Inouye ◽  
Mitsuaki Fujimoto ◽  
Tamami Nakamura ◽  
Toyohide Shinkawa ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Heat Shock ◽  
Heat Shock Transcription Factor ◽  
Activating Transcription Factor 3 ◽  
Activating Transcription Factor ◽  
Transcription Factor 1 ◽  
Transcription Factor 3

scholarly journals Activating transcription factor 3 is downregulated in hepatocellular carcinoma and functions as a tumor suppressor by regulating cyclin D1

2016 ◽  
Vol 11 (1) ◽  
pp. 367-371 ◽  
Author(s):  
Zheng-xia Wang ◽  
Si-neng Yin ◽  
Gang Tian ◽  
Xian-lin Chen
Keyword(s):  
Hepatocellular Carcinoma ◽  
Cell Proliferation ◽  
Transcription Factor ◽  
Tumor Suppressor ◽  
Cyclin D1 ◽  
Real Time ◽  
Real Time Pcr ◽  
Activating Transcription Factor 3 ◽  
Activating Transcription Factor ◽  
Transcription Factor 3

AbstractObjectivesTo investigate the expression as well as biological roles of activating transcription factor 3 (ATF3) in human hepatocellular carcinoma (HCC) cells.MethodsReal time PCR and western blot were applied to detect the expression of ATF3 in human HCC specimens. MTT assay was used to analyze cell proliferation after ATF3 was overexpressed. The expression of cyclin D1 was detected by real time PCR in ATF3-silenced/-overexpressed cells and HCC samples. Correlation coefficient was finally analyzed between ATF3 and cyclin D1 in the HCC samples.ResultsThe expression of ATF3 was found to be downregulated in tested HCC specimens. Cellular MTT assays showed that cell proliferation was suppressed in ATF3-overexpressing HepG2 cells. In addition, cyclin D1 gene expression exhibited negative correlation with ATF3 in both cell lines and tissue samples.ConclusionLow expression of ATF3 may function as a tumor suppressor via inhibiting cyclin D1 in HCC.

2-Aroylquinoline-5,8-diones as potent anticancer agents displaying tubulin and heat shock protein 90 (HSP90) inhibition

2016 ◽  
Vol 14 (2) ◽  
pp. 716-723 ◽  
Author(s):  
Kunal Nepali ◽  
Sunil Kumar ◽  
Hsiang-Ling Huang ◽  
Fei-Chiao Kuo ◽  
Cheng-Hsin Lee ◽  
...  
Keyword(s):  
Heat Shock ◽  
Heat Shock Protein ◽  
Anticancer Agents ◽  
Heat Shock Protein 90 ◽  
Scaffold Hopping ◽  
Hsp90 Inhibition

This study reports the synthesis of a series of 2-aroylquinoline-5,8-diones (11–23) on the basis of scaffold hopping.

scholarly journals Role of activating transcription factor 3 protein ATF3 in necrosis and apoptosis induced by 5-fluoro-2′-deoxyuridine

FEBS Journal ◽  
2014 ◽  
Vol 281 (7) ◽  
pp. 1892-1900 ◽  
Author(s):  
Akira Sato ◽  
Kentaro Nakama ◽  
Hiroki Watanabe ◽  
Akito Satake ◽  
Akihiro Yamamoto ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Activating Transcription Factor 3 ◽  
Activating Transcription Factor ◽  
Transcription Factor 3
Sign in / Sign up

Export Citation Format

Share Document