scholarly journals Growth regulation of simian and human AIDS-related non-Hodgkin's lymphoma cell lines by TGF-β1 and IL-6

BMC Cancer ◽  
2007 ◽  
Vol 7 (1) ◽  
Author(s):  
Kristin R Ruff ◽  
Adriane Puetter ◽  
Laura S Levy
1995 ◽  
Vol 19 (1-2) ◽  
pp. 165-171 ◽  
Author(s):  
Hong Chang ◽  
John A. Blondal ◽  
Sam Benchimol ◽  
Mark D. Minden ◽  
Hans A. Messner

2005 ◽  
Vol 28 (8-9) ◽  
pp. 415-420 ◽  
Author(s):  
Frauke Hugo ◽  
Thomas Dittmar ◽  
Eva K. Treutler ◽  
Kurt S. Zänker ◽  
Jürgen J. Kuehn

2010 ◽  
Vol 2010 ◽  
pp. 1-9 ◽  
Author(s):  
Daniel P. Widney ◽  
Dorina Gui ◽  
Laura M. Popoviciu ◽  
Jonathan W. Said ◽  
Elizabeth C. Breen ◽  
...  

Background. The homeostatic chemokine, CXCL13 (BLC, BCA-1), helps direct the recirculation of mature, resting B cells, which express its receptor, CXCR5. CXCL13/CXCR5 are expressed, and may play a role, in some non-AIDS-associated B cell tumors.Objective. To determine if CXCL13/CXCR5 are associated with AIDS-related non-Hodgkin's lymphoma (AIDS-NHL).Methods. Serum CXCL13 levels were measured by ELISA in 46 subjects who developed AIDS-NHL in the Multicenter AIDS Cohort Study and in controls. The expression or function of CXCL13 and CXCR5 was examined on primary AIDS-NHL specimens or AIDS-NHL cell lines.Results. Serum CXCL13 levels were significantly elevated in the AIDS-NHL group compared to controls. All primary AIDS-NHL specimens showed CXCR5 expression and most also showed CXCL13 expression. AIDS-NHL cell lines expressed CXCR5 and showed chemotaxis towards CXCL13.Conclusions. CXCL13/CXCR5 are expressed in AIDS-NHL and could potentially be involved in its biology. CXCL13 may have potential as a biomarker for AIDS-NHL.


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