scholarly journals Clinical benefit and improvement of activity level after reconstruction surgery of Charcot feet using external fixation: 24-months results of 292 feet

2014 ◽  
Vol 15 (1) ◽  
Author(s):  
Ulrich Illgner ◽  
Tymo Budny ◽  
Inna Frohne ◽  
Nani Osada ◽  
Jan Siewe ◽  
...  
2007 ◽  
Vol 24 (3) ◽  
pp. 583-599 ◽  
Author(s):  
Armin Koller ◽  
Stefan A. Meissner ◽  
Maike Podella ◽  
Raimund Fiedler

Injury ◽  
2010 ◽  
Vol 41 (10) ◽  
pp. 1031-1036 ◽  
Author(s):  
Oliver Pieske ◽  
Felicitas Kaltenhauser ◽  
Leopold Pichlmaier ◽  
Nicolai Schramm ◽  
Heiko Trentzsch ◽  
...  

2019 ◽  
Vol 47 (11) ◽  
pp. 2557-2562 ◽  
Author(s):  
Kate E. Webster ◽  
April L. McPherson ◽  
Timothy E. Hewett ◽  
Julian A. Feller

Background: Many studies have investigated factors that predict a return to sport participation after anterior cruciate ligament (ACL) reconstruction, but it is unclear whether the same factors are associated with a return to preinjury level of sport performance. Purpose: To identify factors that contribute to an athlete’s return to preinjury level of performance after ACL reconstruction. Study Design: Cohort study; Level of evidence, 2. Methods: A cohort of 222 patients (132 male, 90 female) who had ACL reconstruction surgery and completed a 12-month postoperative assessment were followed out to a mean 3 years (range, 2-4 years) to determine whether they had returned to their self-reported preinjury levels of sport performance. Rates of return to preinjury performance were calculated. Measures that had been recorded at the 12-month postoperative review—demographic (age, sex), sport activity level (Marx Activity Rating Scale, return to competition sport), knee laxity, limb symmetry (single and triple crossover hop), subjective function/symptoms (International Knee Documentation Committee subjective), and psychological readiness (Anterior Cruciate Ligament Return to Sport After Injury scale)—were compared between patients who returned to their preinjury levels of performance and those who did not. Univariate and multivariate logistic regression models were also used to prospectively determine the association between these measures and return to preinjury level of sport performance. Results: A total of 135 (61%) patients reported that they had returned to their preinjury levels of performance, with return rates similar between males (59%) and females (63%) and between those who had returned to competition at 12 months (62%) and those who had not (60%). There was no significant age difference between patients who returned to their preinjury levels of sport performance and those who did not; however, higher psychological readiness ( P < .0001), greater limb symmetry ( P < .05), higher subjective knee scores ( P = .01), and a higher activity level ( P < .04) were all associated with a return to performance. In the multivariate model, psychological readiness was the only variable that remained a significant predictor (odds ratio = 1.03; 95% CI, 1.01-1.04; P < .0001). Conclusion: A majority of athletes who returned to sport after ACL reconstruction reported that their performance was comparable with preinjury. Having a greater psychological readiness to return during rehabilitation was the most significant predictor of a subsequent return to comparable performance.


2020 ◽  
Vol 64 (2) ◽  
pp. 325-336 ◽  
Author(s):  
Dimitriya H. Garvanska ◽  
Jakob Nilsson

Abstract Kinetochores are instrumental for accurate chromosome segregation by binding to microtubules in order to move chromosomes and by delaying anaphase onset through the spindle assembly checkpoint (SAC). Dynamic phosphorylation of kinetochore components is key to control these activities and is tightly regulated by temporal and spatial recruitment of kinases and phosphoprotein phosphatases (PPPs). Here we focus on PP1, PP2A-B56 and PP2A-B55, three PPPs that are important regulators of mitosis. Despite the fact that these PPPs share a very similar active site, they target unique ser/thr phosphorylation sites to control kinetochore function. Specificity is in part achieved by PPPs binding to short linear motifs (SLiMs) that guide their substrate specificity. SLiMs bind to conserved pockets on PPPs and are degenerate in nature, giving rise to a range of binding affinities. These SLiMs control the assembly of numerous substrate specifying complexes and their position and binding strength allow PPPs to target specific phosphorylation sites. In addition, the activity of PPPs is regulated by mitotic kinases and inhibitors, either directly at the activity level or through affecting PPP–SLiM interactions. Here, we discuss recent progress in understanding the regulation of PPP specificity and activity and how this controls kinetochore biology.


2004 ◽  
Vol 171 (4S) ◽  
pp. 243-244 ◽  
Author(s):  
Frans Debruyne ◽  
Peter Boyle ◽  
Remigio Vela-Navarrete ◽  
Fernando Calais Da Silva ◽  
Pierre Teillac ◽  
...  
Keyword(s):  

2008 ◽  
Vol 41 (9) ◽  
pp. 52
Author(s):  
MICHELE G. SULLIVAN
Keyword(s):  

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