scholarly journals Improvements in patient-reported outcomes with apremilast, an oral phosphodiesterase 4 inhibitor, in the treatment of moderate to severe psoriasis: results from a phase IIb randomized, controlled study

2013 ◽  
Vol 11 (1) ◽  
pp. 82 ◽  
Author(s):  
Vibeke Strand ◽  
David Fiorentino ◽  
ChiaChi Hu ◽  
Robert M Day ◽  
Randall M Stevens ◽  
...  
Keyword(s):  
Patient Reported Outcomes ◽  
Severe Psoriasis ◽  
Randomized Controlled Study ◽  
Controlled Study ◽  
Phosphodiesterase 4 ◽  
Randomized Controlled ◽  
Patient Reported ◽  
Phosphodiesterase 4 Inhibitor

scholarly journals Patient-Reported Outcomes following Single- and Multiple-Radius Total Knee Replacement: A Randomized, Controlled Trial

2017 ◽  
Vol 31 (01) ◽  
pp. 087-091 ◽  
Author(s):  
Nadeem Mushtaq ◽  
David Isaac ◽  
Katherine Dillow ◽  
Paul Gill ◽  
Alexander Liddle
Keyword(s):  
Total Knee Replacement ◽  
Knee Replacement ◽  
Patient Reported Outcomes ◽  
Controlled Study ◽  
Short Term ◽  
Randomized Controlled ◽  
Significant Difference ◽  
Patient Reported ◽  
Total Knee ◽  
Single Radius

AbstractAlthough single-radius (SR) designs of total knee replacement (TKR) have theoretical benefits, the clinical advantage conferred by such designs is unknown. The aim of this randomized, controlled study was to compare the short-term clinical outcomes of the two design rationales. A total of 105 knees were randomized to receive either a single radius (Scorpio, Stryker; SR Group) or multiple radius (AGC, Zimmer Biomet; MR group) TKR. Patient-reported outcomes (Oxford Knee Score [OKS] and Knee Society Score [KSS]) were collected at 6 weeks, 6 months, and 1 year following surgery. No knees were revised. There was no difference in primary outcomes: OKS was 39.5 (95% confidence interval [CI]: 36.9–42.1) in the SR group and 38.1 (95% CI: 36.0–40.3) in the MR group (p = 0.40). KSS was 168.4 (95% CI: 159.8–177.0) in the SR group; 159.5 (95% CI 150.5–168.5) in the MR group (p = 0.16). There was a small but statistically significant difference in the degree of change of the objective subscale of the KSS, favoring the SR design (p = 0.04), but this is of uncertain clinical relevance. The reported benefits of SR designs do not provide demonstrable functional advantages in the short term.

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