scholarly journals Evaluation of a new semi-automatic strategy for quantitative measurement of infarct size in patients with acute and chronic myocardial infarction using cardiac magnetic resonance imaging

2013 ◽  
Vol 15 (S1) ◽  
Author(s):  
Gunnar Lund ◽  
Dennis Saering ◽  
Kai Muellerleile ◽  
Julia Cuerlis ◽  
Dominik Barz ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Myocardial Infarction ◽  
Cardiac Magnetic Resonance ◽  
Magnetic Resonance ◽  
Infarct Size ◽  
Cardiac Magnetic Resonance Imaging ◽  
Quantitative Measurement ◽  
Chronic Myocardial Infarction ◽  
Resonance Imaging

scholarly journals Using proximity extension proteomics assay to identify biomarkers associated with infarct size and ejection fraction after ST-elevation myocardial infarction

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Moman A. Mohammad ◽  
Sasha Koul ◽  
Anna Egerstedt ◽  
J. Gustav Smith ◽  
Marko Noc ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Myocardial Infarction ◽  
Cardiac Magnetic Resonance ◽  
Magnetic Resonance ◽  
Ejection Fraction ◽  
Infarct Size ◽  
Cardiac Magnetic Resonance Imaging ◽  
Resonance Imaging ◽  
St Elevation ◽  
Inflammatory Proteins

Abstract Plasma concentrations of many cardiovascular and inflammatory proteins are altered after ST-elevation myocardial infarction (STEMI) and may provide prognostic information. We conducted a large-scale proteomic analysis in patients with STEMI, correlating protein levels to infarct size and left ventricular ejection fraction (LVEF) determined with cardiac magnetic resonance imaging. We analysed 131 cardiovascular and inflammatory proteins using a multiplex proximity extension assay and blood samples obtained at baseline, 6, 24, and 96 h from the randomised clinical trial CHILL-MI. Cardiac magnetic resonance imaging data at 4 ± 2 days and 6 months were available as per trial protocol. Using a linear regression model with bootstrap resampling and false discovery rate adjustment we identified five proteins (ST2, interleukin-6, pentraxin-3, interleukin-10, renin, and myoglobin) with elevated values corresponding to larger infarct size or worse LVEF and four proteins (TNF-related apoptosis-inducing ligand, TNF-related activation induced cytokine, interleukin-16, and cystatin B) with values inversely related to LVEF and infarct size, concluding that among 131 circulating inflammatory and cardiovascular proteins in the acute and sub-acute phase of STEMI, nine showed a relationship with infarct size and LVEF post-STEMI, with IL-6 and ST2 exhibiting the strongest association.

scholarly journals In Acute ST-Segment Elevation Myocardial Infarction, Coronary Wedge Pressure Is Associated with Infarct Size and Reperfusion Injury as Evaluated by Cardiac Magnetic Resonance Imaging

2020 ◽  
Vol 2020 ◽  
pp. 1-7
Author(s):  
Mihaela Ioana Dregoesc ◽  
Raluca Bianca Dumitru ◽  
Sorana Daniela Bolboacă ◽  
Mădălin Constantin Marc ◽  
Simona Manole ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Myocardial Infarction ◽  
Cardiac Magnetic Resonance ◽  
Magnetic Resonance ◽  
Infarct Size ◽  
Cardiac Magnetic Resonance Imaging ◽  
Reperfusion Injury ◽  
Microvascular Obstruction ◽  
Resonance Imaging ◽  
Wedge Pressure

Background. Coronary collateral flow influences patient prognosis in the setting of acute myocardial infarction. However, few data exist about the relation between coronary collaterals, infarct size, and reperfusion injury. The angiographic Rentrop score is prone to subjectivism and to the inherent limitations of angiographic images. Its prognostic value is controversial in the setting of acute myocardial infarction. The invasive measurement of coronary wedge pressure (CWP) represents an alternative to Rentrop score for the evaluation of coronary collateralization. Our study evaluates pre-revascularization CWP as a predictor of infarct size and reperfusion injury as evaluated by cardiac magnetic resonance imaging. Methods. Patients with acute ST-elevation myocardial infarction underwent preprocedural CWP measurement and primary percutaneous coronary intervention. Infarct size, microvascular obstruction, intramyocardial edema, and intramyocardial hemorrhage were evaluated by cardiac magnetic resonance imaging. Results. Mean CWP was inversely associated with infarct size p=0.01, microvascular obstruction p=0.02, intramyocardial edema p=0.05, and intramyocardial hemorrhage p=0.01. An excellent association was found between mean CWP and an infarct size ≥24% of left ventricular mass (AUC = 0.880, p=0.007), with an optimal cutoff value ≤24.5 mmHg. Both intramyocardial edema p=0.02 and hemorrhage p=0.03 had a larger extent in patients with coronary wedge pressure ≤24.5 mmHg. Rentrop grade <2 was associated with larger infarct size p=0.03, but not with the extent of edema, microvascular obstruction, or intramyocardial hemorrhage. Conclusions. Pre-revascularization CWP was a predictor of infarct size and was significantly associated with a larger extent of intramyocardial edema and intramyocardial hemorrhage. Rentrop grade <2 was associated with a larger infarct size, but had no influence on reperfusion injury. The clinical trial is registered with NCT03371784.

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