TLR4 mutation reduces microglial activation, increases Aβ deposits and exacerbates cognitive deficits in a mouse model of Alzheimer's disease

Min Song; JingJi Jin; Jeong-Eun Lim; Jinghong Kou; Abhinandan Pattanayak; Jamaal A Rehman; Hong-Duck Kim; Kazuki Tahara; Robert Lalonde; Ken-ichiro Fukuchi

doi:10.1186/1742-2094-8-92

TLR4 mutation reduces microglial activation, increases Aβ deposits and exacerbates cognitive deficits in a mouse model of Alzheimer's disease

Journal of Neuroinflammation ◽

10.1186/1742-2094-8-92 ◽

2011 ◽

Vol 8 (1) ◽

pp. 92 ◽

Cited By ~ 155

Author(s):

Min Song ◽

JingJi Jin ◽

Jeong-Eun Lim ◽

Jinghong Kou ◽

Abhinandan Pattanayak ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Mouse Model ◽

Cognitive Deficits ◽

Microglial Activation ◽

Model Of Alzheimer’S Disease

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Faculty Opinions recommendation of Inhibition of mTOR by rapamycin abolishes cognitive deficits and reduces amyloid-beta levels in a mouse model of Alzheimer's disease.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.717977209.793470743 ◽

2013 ◽

Author(s):

Matt Kaeberlein

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Mouse Model ◽

Amyloid Beta ◽

Cognitive Deficits ◽

Model Of Alzheimer’S Disease

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Faculty Opinions recommendation of Inhibitor of the tyrosine phosphatase STEP reverses cognitive deficits in a mouse model of Alzheimer's disease.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.718520520.793504888 ◽

2015 ◽

Author(s):

Amy Barrios

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Mouse Model ◽

Cognitive Deficits ◽

Tyrosine Phosphatase ◽

Model Of Alzheimer’S Disease

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Faculty Opinions recommendation of A novel GLP-1/GIP/Gcg triagonist reduces cognitive deficits and pathology in the 3xTg mouse model of Alzheimer's disease.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.732740978.793572425 ◽

2020 ◽

Author(s):

Venkateswarlu Kanamarlapudi

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Mouse Model ◽

Cognitive Deficits ◽

Model Of Alzheimer’S Disease

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Genetic ablation of the p66Shc adaptor protein reverses cognitive deficits and improves mitochondrial function in an APP transgenic mouse model of Alzheimer’s disease

Molecular Psychiatry ◽

10.1038/mp.2016.112 ◽

2016 ◽

Vol 22 (4) ◽

pp. 605-614 ◽

Cited By ~ 13

Author(s):

R Derungs ◽

G G Camici ◽

R D Spescha ◽

T Welt ◽

C Tackenberg ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Mouse Model ◽

Transgenic Mouse ◽

Cognitive Deficits ◽

Mitochondrial Function ◽

Adaptor Protein ◽

Transgenic Mouse Model ◽

Genetic Ablation ◽

Model Of Alzheimer’S Disease

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P1-033: Cognitive deficits and plaque deposition in a gene-targeted mouse model of Alzheimer's disease

Alzheimer s & Dementia ◽

10.1016/j.jalz.2009.04.036 ◽

2009 ◽

Vol 5 (4S_Part_6) ◽

pp. P181-P181

Author(s):

John Ciallella ◽

Heather Hain ◽

Bryan Strenkowski ◽

Michelle Hogga ◽

Stacey Galvin ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Mouse Model ◽

Cognitive Deficits ◽

Plaque Deposition ◽

Model Of Alzheimer’S Disease

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Oral administration of methysticin improves cognitive deficits in a mouse model of Alzheimer's disease

Redox Biology ◽

10.1016/j.redox.2017.04.024 ◽

2017 ◽

Vol 12 ◽

pp. 843-853 ◽

Cited By ~ 30

Author(s):

Athanassios Fragoulis ◽

Stephanie Siegl ◽

Markus Fendt ◽

Sandra Jansen ◽

Ulf Soppa ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Mouse Model ◽

Oral Administration ◽

Cognitive Deficits ◽

Model Of Alzheimer’S Disease

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P3-420: Special lipid-based diets alleviate cognitive deficits in the APPswe/PS1dE9 transgenic mouse model of Alzheimer's disease independent of brain amyloid deposition

Alzheimer s & Dementia ◽

10.1016/j.jalz.2011.05.1863 ◽

2011 ◽

Vol 7 ◽

pp. S650-S650 ◽

Cited By ~ 1

Author(s):

Laus Broersen ◽

Hennariikka Koivisto ◽

M. Takalo ◽

Pasi Miettinen ◽

Heikki Tanila

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Mouse Model ◽

Transgenic Mouse ◽

Cognitive Deficits ◽

Transgenic Mouse Model ◽

Amyloid Deposition ◽

Model Of Alzheimer’S Disease ◽

Brain Amyloid Deposition

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Green Coconut Water Attenuates Oxidative Damage, Amyloid Pathology and Cognitive Deficits in a Mouse Model of Alzheimer's disease

IBRO Reports ◽

10.1016/j.ibror.2019.09.048 ◽

2019 ◽

Vol 7 ◽

pp. 22

Author(s):

N.E. Umahi ◽

E.E. Edem ◽

A.A. Bakare ◽

A.A. Oremosu

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Mouse Model ◽

Oxidative Damage ◽

Cognitive Deficits ◽

Coconut Water ◽

Amyloid Pathology ◽

Model Of Alzheimer’S Disease

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Soluble Aβ levels correlate with cognitive deficits in the 12-month-old APPswe/PS1dE9 mouse model of Alzheimer's disease

Behavioural Brain Research ◽

10.1016/j.bbr.2011.03.072 ◽

2011 ◽

Vol 222 (2) ◽

pp. 342-350 ◽

Cited By ~ 60

Author(s):

Wei Zhang ◽

Jian Hao ◽

Rui Liu ◽

Zhuo Zhang ◽

Gesheng Lei ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Mouse Model ◽

Cognitive Deficits ◽

Model Of Alzheimer’S Disease

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β-Alanyl-L-Histidine Rescues Cognitive Deficits Caused by Feeding a High Fat Diet in a Transgenic Mouse Model of Alzheimer's Disease

Journal of Alzheimer s Disease ◽

10.3233/jad-2012-121324 ◽

2013 ◽

Vol 33 (4) ◽

pp. 983-997 ◽

Cited By ~ 64

Author(s):

Bruno Herculano ◽

Minami Tamura ◽

Ayaka Ohba ◽

Mayu Shimatani ◽

Natsumaro Kutsuna ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Mouse Model ◽

Transgenic Mouse ◽

Cognitive Deficits ◽

High Fat Diet ◽

Transgenic Mouse Model ◽

High Fat ◽

Model Of Alzheimer’S Disease

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