Assessing drug distribution in tissues expressing P-glycoprotein through physiologically based pharmacokinetic modeling: model structure and parameters determination

Model Structure ◽

P Glycoprotein ◽

Assessing drug distribution in tissues expressing P-glycoprotein using physiologically based pharmacokinetic modeling: identification of important model parameters through global sensitivity analysis

Journal of Pharmacokinetics and Pharmacodynamics ◽

10.1007/s10928-009-9134-8 ◽

2009 ◽

Vol 36 (6) ◽

pp. 495-522 ◽

Cited By ~ 10

Author(s):

Frederique Fenneteau ◽

Jun Li ◽

Fahima Nekka

Keyword(s):

Sensitivity Analysis ◽

Global Sensitivity Analysis ◽

Drug Distribution ◽

Model Parameters ◽

Global Sensitivity ◽

P Glycoprotein ◽

Unraveling pleiotropic effects of rifampicin by using physiologically based pharmacokinetic modeling: Assessing the induction magnitude of P‐glycoprotein–cytochrome P450 3A4 dual substrates

10.1002/psp4.12717 ◽

2021 ◽

Author(s):

Xian Pan ◽

Shinji Yamazaki ◽

Sibylle Neuhoff ◽

Mian Zhang ◽

Venkatesh Pilla Reddy

Keyword(s):

Cytochrome P450 ◽

Pleiotropic Effects ◽

Cytochrome P450 3A4 ◽

P Glycoprotein ◽

Application of Physiologically Based Pharmacokinetic Modeling in Understanding Bosutinib Drug-Drug Interactions: Importance of Intestinal P-Glycoprotein

Drug Metabolism and Disposition ◽

10.1124/dmd.118.080424 ◽

2018 ◽

Vol 46 (8) ◽

pp. 1200-1211 ◽

Cited By ~ 4

Author(s):

Shinji Yamazaki ◽

Cho-Ming Loi ◽

Emi Kimoto ◽

Chester Costales ◽

Manthena V. Varma

Keyword(s):

Drug Interactions ◽

P Glycoprotein ◽

Assessing Potential Drug-Drug Interactions Between Dabigatran Etexilate and a P-Glycoprotein Inhibitor in Renal Impairment Populations Using Physiologically Based Pharmacokinetic Modeling

10.1002/psp4.12382 ◽

2019 ◽

Vol 8 (2) ◽

pp. 118-126 ◽

Cited By ~ 5

Author(s):

Kosuke Doki ◽

Sibylle Neuhoff ◽

Amin Rostami-Hodjegan ◽

Masato Homma

Keyword(s):

Renal Impairment ◽

Drug Interactions ◽

Dabigatran Etexilate ◽

Potential Drug ◽

P Glycoprotein ◽

Physiologically‐Based Pharmacokinetic Modeling Approach to Predict Rifampin‐Mediated Intestinal P‐Glycoprotein Induction

10.1002/psp4.12458 ◽

2019 ◽

Vol 8 (9) ◽

pp. 634-642 ◽

Cited By ~ 10

Author(s):

Shinji Yamazaki ◽

Chester Costales ◽

Sarah Lazzaro ◽

Soraya Eatemadpour ◽

Emi Kimoto ◽

...

Keyword(s):

Modeling Approach ◽

P Glycoprotein ◽

Physiologically‐Based Pharmacokinetic Modeling for the Prediction of a Drug–Drug Interaction of Combined Effects on P‐glycoprotein and Cytochrome P450 3A

10.1002/psp4.12562 ◽

2020 ◽

Vol 9 (11) ◽

pp. 659-669

Author(s):

Yukio Otsuka ◽

Mary P. Choules ◽

Peter L. Bonate ◽

Kanji Komatsu

Keyword(s):

Cytochrome P450 ◽

Drug Interaction ◽

Combined Effects ◽

Cytochrome P450 3A ◽

P Glycoprotein ◽

Physiologically Based ◽

Drug Drug Interaction

Physiologically-based pharmacokinetic modeling of different size polyethylene glycol-coated gold nanoparticles in mice

10.1615/ihtc16.nmt.023362 ◽

2018 ◽

Author(s):

Linjing Deng ◽

Jinping Zhao ◽

Yufeng Miao ◽

Xu Hu ◽

Qihong Deng

Keyword(s):

Gold Nanoparticles ◽

Polyethylene Glycol ◽

Physiologically-Based Pharmacokinetic Modeling to Predict Changes in Drug Exposure during Pregnancy Using the Simcyp Simulator

10.26226/morressier.57d6b2b7d462b8028d88e945 ◽

2016 ◽

Author(s):

Suvarchala Kiranmai Avvari

Keyword(s):

Drug Exposure ◽

Physiologically Based ◽

Exposure During Pregnancy

Physiologically‐Based Pharmacokinetic Modeling of Atorvastatin Incorporating Delayed Gastric Emptying and Acid‐to‐Lactone Conversion

10.1002/psp4.12447 ◽

2019 ◽

Vol 8 (9) ◽

pp. 664-675 ◽

Cited By ~ 5

Author(s):

Bridget L. Morse ◽

Jeffrey J. Alberts ◽

Maria M. Posada ◽

Jessica Rehmel ◽

Anil Kolur ◽

...

Keyword(s):

Gastric Emptying ◽

Delayed Gastric Emptying ◽

Preliminary physiologically based pharmacokinetic modeling of renally cleared drugs in Chinese pregnant women

Biopharmaceutics & Drug Disposition ◽

10.1002/bdd.2243 ◽

2020 ◽

Vol 41 (6) ◽

pp. 248-267 ◽

Cited By ~ 1

Author(s):

Ling Song ◽

Zhiheng Yu ◽

Yifan Xu ◽

Xiaobei Li ◽

Xuanlin Liu ◽

...

Keyword(s):

Pregnant Women ◽