Association of Vitamin D3 levels with glycemic control in Type 2 diabetes subjects from Gujarati population-India

Background: It has been estimated that at least one billion people worldwide have vitamin D3 deficiency. Type 2 diabetes mellitus has consistently been shown to be prevalent in individuals with vitamin D3 deficiency. This study focuses on exploring if there is any association between vitamin D3 deficiency, type 2 diabetes mellitus and glycemic control, by measuring HbA1c levels, after vitamin D3 supplementation.Methods: 77 patients with confirmed type II diabetes mellitus were enrolled during the study. Pre and post treatment (after 3 month) laboratory investigations - FBS, PPBS, HbA1c and serum vitamin D3 levels were done in all the patients. Patients were classified into two groups. Group 1 - vitamin D3 < 30 ng/ml (n=41) and group 2 - vitamin D3 ≥30 ng/ml (n=36). Group 1 was given 60,000 IU of calcitriol sachet weekly for 8 weeks followed by 60,000 IU once a month. No vitamin D3 supplementation was given to group 2.Results: Vitamin D3 supplementation in group 1, has resulted in number of patients with control on HbA1c (< 7%) increased from 8 to 17 (a more than 100% increase). Number of patients with control on FBS (<130 mg/dl) increased from 14 to 23 (64% increase). Conclusions: There is a positive association between vitamin D3 status and glycemic control in type 2 diabetic mellitus patients. Vitamin D3 supplementation in deficient group has resulted in significant reduction in HbA1c level (p<0.001).

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Association of serum vitamin D level with glycemic control in patients with type 2 diabetes mellitus

Zanco Journal of Medical Sciences ◽

10.15218/zjms.2020.047 ◽

2020 ◽

Vol 24 (3) ◽

pp. 395-400

Author(s):

Dler Kakil ◽

Mohammed Meena

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Vitamin D ◽

Type 2 Diabetes Mellitus ◽

Glycemic Control ◽

Vitamin D3 ◽

Serum Vitamin ◽

Diabetic Patients ◽

The Mean

Background and objective: Vitamin D deficiency appears to be related to the development of diabetes mellitus type 2 and metabolic syndrome. This study aimed to assess the association between the level of 25-hydroxy vitamin D{25(OH)D3 and the glycemic control in patients with type 2 diabetes. Methods: This case-control study involved 240 participants divided into two groups, 119 patients with type 2 diabetic mellitus and 120 healthy individuals as a control group. The study was conducted in Layla Qassim Diabetic Center in Erbil from March 2018 to March 2019. The data were collected from all the cases, including history and physical examination, using a specially designed questionnaire. From all cases, blood was taken, and samples were sent to the laboratory for serum vitamin D3 level estimation. Results: From the total of 240 participants, the mean age of cases was 54.04 ± 10.56 years and of controls was 53.12 ± 9.84 years. The mean serum vitamin D3 level of the cases was 9.21 ± 5.69ng/ml, and it was non-significantly (P = 0.3) higher than the control (8.61±4.57)ng/ml. Both groups were within the vitamin D deficient range. Vitamin D level was non-significantly deficient in 84 (70.6%) of diabetic patients compared to 89(73.6%) of control. There was a non-significant difference in vitamin D level in poorly controlled diabetic patients compared to well-controlled diabetic patients (P = 0.584). Conclusion: No significant association was detected between vitamin D level and glycemic control. Keywords: Type 2 diabetes mellitus; Vitamin D3 level; Glycemic control.

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Correlation between Vitamin D and HbA1c in Type 2 Diabetic Patients

Academia Journal of Medicine ◽

10.47008/ajm.2020.3.1.2 ◽

2020 ◽

Vol 3 (1) ◽

pp. 4-10

Author(s):

Sudhir Chandra Jha ◽

Himanshu Kumar ◽

Syed Yousuf Faisal

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Vitamin D ◽

Type 2 Diabetes Mellitus ◽

Glycemic Control ◽

Vitamin D3 ◽

Diabetes Mellitus Type 2 ◽

Diabetes Mellitus Type ◽

Inverse Association

Background: Diabetes is a metabolic disorder that can affect nearly every organ system in the body. Recently, Vitamin D3 was given some importance worldwide in the pathogenesis of diabetes. The extraskeletal effects of Vitamin D3 have attracted considerable interest. The identification of 1,25(OH)2D3 and 1-Alpha-Hydroylase expression in pancreatic Beta cells, in cells of the immune system,and in various other tissues besides the bone system , supports the role of Vit D3 in the pathogenesis of type 2 diabetes. Vit D3 deficiency appears to be related to development of diabetes mellitus type 2 and metabolic syndrome. Aim of the Study:The goal of this study is to find out whether this correlation between vitamin D and Diabetes is present or not. Mainly in this study we have tried to correlate vit D with HbA1C levels in patients with type 2 diabetes mellitus. Subjects and Methods: The present one and half years, cross sectional study was carried out in department of medicine, Darbhanga Medical College and Hospital, Darbhanga, Bihar from March – 2018 to September – 2019. A total of 125 patients with type 2 Diabetes Mellitus were studied. The estimation of vitamin D was done. Using Siemens, ADVIA centraurVit D assay a one pass 18 minute antibody competitive immunassay. Results: Maximum no. of cases was in the age group of 51 to 60 that is 40 patients (32%).The mean age of studied population was 60.22 +- 11.65 years. Out of 125 patients 77(61.6%) were males and 48 patients (38.4%) were females, with a ratio of male to female of 1.60:1. In 104 patients (83.2%), the level of vitamin D were below normal, in 11 patients (8.8%) the levels insufficient and in remaining 10 patients , the levels were either normal or more than normal. Conclusion: There was an inverse association between vitamin D and HbA1C in patients with type -2 Diabetes Mellitus. Lower Vit D levels are associated with poor glycemic control. That means – Low vit D – high HbA1C. Vitamin D deficiency is prevalent in Diabetes mellitus type 2 so by supplementation of vitamin D we can improve glycemic controls in patients of Diabetes mellitus type 2. By improving glycemic control, we can reduce the complication of Diabetes.

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