scholarly journals Association analysis of PRNP gene region with chronic wasting disease in Rocky Mountain elk

2010 ◽  
Vol 3 (1) ◽  
Author(s):  
Stephen N White ◽  
Terry R Spraker ◽  
James O Reynolds ◽  
Katherine I O'Rourke
Keyword(s):  
Association Analysis ◽  
Chronic Wasting Disease ◽  
Rocky Mountain ◽  
Prnp Gene ◽  
Gene Region ◽  
Wasting Disease ◽  
Rocky Mountain Elk

scholarly journals PrP genotypes of captive and free-ranging Rocky Mountain elk (Cervus elaphus nelsoni) with chronic wasting disease

1999 ◽  
Vol 80 (10) ◽  
pp. 2765-2679 ◽  
Author(s):  
K. I. O’Rourke ◽  
T. E. Besser ◽  
M. W. Miller ◽  
T. F. Cline ◽  
T. R. Spraker ◽  
...  
Keyword(s):  
Cervus Elaphus ◽  
Chronic Wasting Disease ◽  
Rocky Mountain ◽  
Transmissible Spongiform Encephalopathies ◽  
Spongiform Encephalopathy ◽  
Wasting Disease ◽  
Jakob Disease ◽  
Rocky Mountain Elk ◽  
Free Ranging ◽  
Prp Gene

The PrP gene encodes the putative causative agent of the transmissible spongiform encephalopathies (TSEs), a heterogeneous group of fatal, neurodegenerative disorders including human Creutzfeldt–Jakob disease, bovine spongiform encephalopathy, ovine scrapie and chronic wasting disease (CWD) of North American deer and elk. Polymorphisms in the PrP gene are associated with variations in relative susceptibility, pathological lesion patterns, incubation times and clinical course of TSEs of humans, mice and sheep. Sequence analysis of the PrP gene from Rocky Mountain elk showed only one amino acid change (Met to Leu at cervid codon 132). Homozygosity for Met at the corresponding polymorphic site (Met to Val) in humans (human codon 129) predisposes exposed individuals to some forms of Creutzfeldt–Jakob disease. In this study, Rocky Mountain elk homozygous for PrP codon 132 Met were over-represented in both free- ranging and farm-raised CWD-affected elk when compared to unaffected control groups.

scholarly journals Detection of PrPCWDin Postmortem Rectal Lymphoid Tissues in Rocky Mountain Elk (Cervus Elaphus Nelsoni) Infected with Chronic Wasting Disease

2006 ◽  
Vol 18 (6) ◽  
pp. 553-557 ◽  
Author(s):  
Terry R. Spraker ◽  
Thomas L. Gidlewski ◽  
Aru Balachandran ◽  
Kurt C. VerCauteren ◽  
Lynn Creekmore ◽  
...  
Keyword(s):  
Cervus Elaphus ◽  
Chronic Wasting Disease ◽  
Rocky Mountain ◽  
Lymphoid Tissues ◽  
Wasting Disease ◽  
Cervus Elaphus Nelsoni ◽  
Rocky Mountain Elk

scholarly journals In utero transmission and tissue distribution of chronic wasting disease-associated prions in free-ranging Rocky Mountain elk

2015 ◽  
Vol 96 (11) ◽  
pp. 3444-3455 ◽  
Author(s):  
Anca Selariu ◽  
Jenny G. Powers ◽  
Amy Nalls ◽  
Monica Brandhuber ◽  
Amber Mayfield ◽  
...  
Keyword(s):  
Tissue Distribution ◽  
Chronic Wasting Disease ◽  
Rocky Mountain ◽  
In Utero ◽  
Wasting Disease ◽  
Rocky Mountain Elk ◽  
Free Ranging

scholarly journals Progressive accumulation of the abnormal conformer of the prion protein and spongiform encephalopathy in the obex of nonsymptomatic and symptomatic Rocky Mountain elk (Cervus elaphus nelsoni) with chronic wasting disease

2015 ◽  
Vol 27 (4) ◽  
pp. 431-441 ◽  
Author(s):  
Terry R. Spraker ◽  
Thomas Gidlewski ◽  
Jenny G. Powers ◽  
Tracy Nichols ◽  
Aru Balachandran ◽  
...  
Keyword(s):  
Prion Protein ◽  
Cervus Elaphus ◽  
Chronic Wasting Disease ◽  
Rocky Mountain ◽  
Wasting Disease ◽  
Cervus Elaphus Nelsoni ◽  
Single Section ◽  
Spongiform Degeneration ◽  
Rocky Mountain Elk ◽  
Progressive Accumulation

The purpose of our study was to describe the progressive accumulation of the abnormal conformer of the prion protein (PrPCWD) and spongiform degeneration in a single section of brain stem in Rocky Mountain elk ( Cervus elaphus nelsoni) with chronic wasting disease (CWD). A section of obex from 85 CWD-positive elk was scored using the presence and abundance of PrPCWD immunoreactivity and spongiform degeneration in 10 nuclear regions and the presence and abundance of PrPCWD in 10 axonal tracts, the subependymal area of the fourth ventricle, and the thin subpial astrocytic layer (glial limitans). Data was placed in a formula to generate an overall obex score. Data suggests that PrPCWD immunoreactivity and spongiform degeneration has a unique and relatively consistent pattern of progression throughout a section of obex. This scoring technique utilizing a single section of obex may prove useful in future work for estimating the presence and abundance of PrPCWD in peripheral tissues and the nervous system in elk with CWD.

EPIDEMIOLOGY OF CHRONIC WASTING DISEASE IN CAPTIVE ROCKY MOUNTAIN ELK

1998 ◽  
Vol 34 (3) ◽  
pp. 532-538 ◽  
Author(s):  
Michael W. Miller ◽  
Margaret A. Wild ◽  
Elizabeth S. Williams
Keyword(s):  
Chronic Wasting Disease ◽  
Rocky Mountain ◽  
Wasting Disease ◽  
Rocky Mountain Elk

scholarly journals Detection of two dissimilar chronic wasting disease isolates in two captive Rocky Mountain elk (Cervus canadensis) herds

Prion ◽  
2021 ◽  
Vol 15 (1) ◽  
pp. 207-215
Author(s):  
Tracy A. Nichols ◽  
Eric M. Nicholson ◽  
Yihui Liu ◽  
Wanyun Tao ◽  
Terry R. Spraker ◽  
...  
Keyword(s):  
Chronic Wasting Disease ◽  
Rocky Mountain ◽  
Wasting Disease ◽  
Cervus Canadensis ◽  
Rocky Mountain Elk

scholarly journals Gene expression alterations in Rocky Mountain elk infected with chronic wasting disease

Prion ◽  
2012 ◽  
Vol 6 (3) ◽  
pp. 282-301 ◽  
Author(s):  
Urmila Basu ◽  
Luciane M. Almeida ◽  
Sandor Dudas ◽  
Catherine E. Graham ◽  
Stefanie Czub ◽  
...  
Keyword(s):  
Gene Expression ◽  
Chronic Wasting Disease ◽  
Rocky Mountain ◽  
Wasting Disease ◽  
Rocky Mountain Elk ◽  
Gene Expression Alterations
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