scholarly journals Alzheimer’s disease drug-development pipeline: few candidates, frequent failures

2014 ◽  
Vol 6 (4) ◽  
pp. 37 ◽  
Author(s):  
Jeffrey L Cummings ◽  
Travis Morstorf ◽  
Kate Zhong
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Drug Development ◽  
Development Pipeline

Old Drugs with New Tricks; Paradigm in Drug Development Pipeline for Alzheimer’s Disease

2020 ◽  
Vol 20 ◽  
Author(s):  
Tanay Dalvi ◽  
Bhaskar Dewangan ◽  
Rudradip Das ◽  
Jyoti Rani ◽  
Suchita Dattatray Shinde ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Drug Development ◽  
Molecular Targets ◽  
Drug Repurposing ◽  
Phase Iii ◽  
Complex Nature ◽  
New Drug ◽  
Development Pipeline ◽  
Old Drugs

: The most common reason behind dementia is Alzheimer’s disease (AD) and it is predicted to be the third lifethreatening disease apart from stroke and cancer for the geriatric population. Till now only four drugs are available in the market for symptomatic relief. The complex nature of disease pathophysiology and lack of concrete evidences of molecular targets are the major hurdles for developing new drug to treat AD. The the rate of attrition of many advanced drugs at clinical stages, makes the de novo discovery process very expensive. Alternatively, Drug Repurposing (DR) is an attractive tool to develop drugs for AD in a less tedious and economic way. Therefore, continuous efforts are being made to develop a new drug for AD by repursing old drugs through screening and data mining. For example, the survey in the drug pipeline for Phase III clinical trials (till February 2019) which has 27 candidates, and around half of the number are drugs which have already been approved for other indications. Although in the past the drug repurposing process for AD has been reviewed in the context of disease areas, molecular targets, there is no systematic review of repurposed drugs for AD from the recent drug development pipeline (2019-2020). In this manuscript, we are reviewing the clinical candidates for AD with emphasis on their development history including molecular targets and the relevance of the target for AD.

scholarly journals Alzheimer's disease drug development pipeline: 2019

2019 ◽  
Vol 5 (1) ◽  
pp. 272-293 ◽  
Author(s):  
Jeffrey Cummings ◽  
Garam Lee ◽  
Aaron Ritter ◽  
Marwan Sabbagh ◽  
Kate Zhong
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Drug Development ◽  
Development Pipeline

scholarly journals Alzheimer's disease drug development pipeline: 2021

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Jeffrey Cummings ◽  
Garam Lee ◽  
Kate Zhong ◽  
Jorge Fonseca ◽  
Kazem Taghva
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Drug Development ◽  
Development Pipeline

scholarly journals Alzheimer's disease drug development pipeline: 2017

2017 ◽  
Vol 3 (3) ◽  
pp. 367-384 ◽  
Author(s):  
Jeffrey Cummings ◽  
Garam Lee ◽  
Travis Mortsdorf ◽  
Aaron Ritter ◽  
Kate Zhong
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Drug Development ◽  
Development Pipeline

scholarly journals Alzheimer's disease drug development pipeline: 2020

2020 ◽  
Vol 6 (1) ◽  
Author(s):  
Jeffrey Cummings ◽  
Garam Lee ◽  
Aaron Ritter ◽  
Marwan Sabbagh ◽  
Kate Zhong
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Drug Development ◽  
Development Pipeline

scholarly journals Alzheimer's disease drug development pipeline: 2018

2018 ◽  
Vol 4 (1) ◽  
pp. 195-214 ◽  
Author(s):  
Jeffrey Cummings ◽  
Garam Lee ◽  
Aaron Ritter ◽  
Kate Zhong
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Drug Development ◽  
Development Pipeline

Characterization of a sensitive mouse Aβ40 PD biomarker assay for Alzheimer's disease drug development in wild-type mice

Bioanalysis ◽  
2016 ◽  
Vol 8 (10) ◽  
pp. 1067-1075 ◽  
Author(s):  
Yanmei Lu ◽  
Kwame Hoyte ◽  
William H Montgomery ◽  
Wilman Luk ◽  
Dongping He ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Drug Development ◽  
Wild Type

scholarly journals Advances in recent patent and clinical trial drug development for Alzheimer’s disease

2014 ◽  
Vol 3 (4) ◽  
pp. 429-447 ◽  
Author(s):  
Haibin Liu ◽  
Lirong Wang ◽  
Weiwei Su ◽  
Xiang-Qun Xie
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Clinical Trial ◽  
Drug Development ◽  
Trial Drug
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