scholarly journals Pressure support ventilation versus bilevel positive airway pressure for acute exacerbation of chronic obstructive pulmonary disease: a randomized trial

Critical Care ◽  
2001 ◽  
Vol 5 (S3) ◽  
Author(s):  
MA Scarpinella-Bueno ◽  
M Rodrigues ◽  
C Hoelz ◽  
VM Amado ◽  
CSV Barbas ◽  
...  
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Randomized Trial ◽  
Acute Exacerbation ◽  
Pressure Support Ventilation ◽  
Airway Pressure ◽  
Pressure Support ◽  
Positive Airway Pressure ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Bilevel Positive Airway Pressure

Bone Marrow Mesenchymal Stem Cell Transplantation in Combination with Nasal Continuous Positive Airway Pressure Improves Acute Exacerbation of Chronic Obstructive Pulmonary Disease (AECOPD)

2022 ◽  
Vol 12 (3) ◽  
pp. 641-646
Author(s):  
Minna Wu ◽  
Bo Xu
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Bone Marrow ◽  
Stem Cell ◽  
Continuous Positive Airway Pressure ◽  
Mesenchymal Stem Cell ◽  
Acute Exacerbation ◽  
Airway Pressure ◽  
Positive Airway Pressure ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease

We aimed to explore the efficacy of bone marrow mesenchymal stem cell (BMSC) transplantation combined with nasal continuous positive airway pressure (nCPAP) for treating severe acute exacerbation of chronic obstructive pulmonary disease (AECOPD). SD rat AECOPD model was established by injecting endotoxin and Staphylococcus aureus and then treated with nCPAP, BMSCs, or nCPAP combined with BMSCs (n = 20) and their conditions were evaluated with BBB score at 1 d, 3 d, 7 d, 14 d, 28 d after treatment along with analysis of apoptosis and BrdU-positive cells as well as NF200 expression by TUNEL kit staining and levels of Th1, Th7 and Th12 before and after treatment. As revealed by BBB score and HE staining, all treatments significantly alleviated the symptom of severe APEOPD (p < 0.05), while compared with nCPAP, the combined treatment exhibited higher efficacy. Besides, upon treatment, apoptosis and level of Th1, Th7 and Th12 was reduced but N200 absorbance value was elevated, with significant difference in combination group (p < 0.05). In conclusion, BMSC transplantation in combination with nCPAP alleviates severe AECOPD by reducing cell apoptosis, repairing cell damage, and regulating T-cell subsets.

scholarly journals Ventimask in exacerbation of chronic obstructive pulmonary disease and mild acidosis before starting with bilevel positive airway pressure

2014 ◽  
Vol 10 (2) ◽  
Author(s):  
Andrea Bellone ◽  
Luca Motta ◽  
Massimiliano Etteri ◽  
Anna Maria Bianchi ◽  
Anna Cappelletti ◽  
...  
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Disease ◽  
Airway Pressure ◽  
Positive Airway Pressure ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Bilevel Positive Airway Pressure
Sign in / Sign up

Export Citation Format

Share Document