scholarly journals How quick is soon? Early response to continuous positive airway pressure: a randomized controlled trial

Critical Care ◽  
2008 ◽  
Vol 12 (Suppl 2) ◽  
pp. P344 ◽  
Author(s):  
J Crawford ◽  
R Otero ◽  
EP Rivers ◽  
T Lenoir ◽  
J Garcia
Keyword(s):  
Randomized Controlled Trial ◽  
Continuous Positive Airway Pressure ◽  
Airway Pressure ◽  
Positive Airway Pressure ◽  
Controlled Trial ◽  
Early Response ◽  
Randomized Controlled

scholarly journals Effect of continuous positive airway pressure on inflammatory, antioxidant, and depression biomarkers in women with obstructive sleep apnea: a randomized controlled trial

SLEEP ◽  
2019 ◽  
Vol 42 (10) ◽  
Author(s):  
Francisco Campos-Rodriguez ◽  
Maria Isabel Asensio-Cruz ◽  
Jose Cordero-Guevara ◽  
Bernabe Jurado-Gamez ◽  
Carmen Carmona-Bernal ◽  
...  
Keyword(s):  
Antioxidant Activity ◽  
Randomized Controlled Trial ◽  
Obstructive Sleep Apnea ◽  
Continuous Positive Airway Pressure ◽  
Airway Pressure ◽  
Positive Airway Pressure ◽  
Controlled Trial ◽  
Cpap Therapy ◽  
Randomized Controlled ◽  
Obstructive Sleep

AbstractStudy ObjectivesThe effect of continuous positive airway pressure (CPAP) on mediators of cardiovascular disease and depression in women with obstructive sleep apnea (OSA) is unknown. We aimed to assess the effect of CPAP therapy on a variety of biomarkers of inflammation, antioxidant activity, and depression in women with OSA.MethodsWe conducted a multicenter, randomized controlled trial in 247 women diagnosed with moderate-to-severe OSA (apnea–hypopnea index [AHI] ≥ 15). Women were randomized to CPAP (n = 120) or conservative treatment (n = 127) for 12 weeks. Changes in tumor necrosis factor α (TNFα), interleukin 6 (IL-6), C-reactive protein (CRP), intercellular adhesion molecule 1 (ICAM-1), catalase (CAT), superoxide dismutase (SOD), and brain-derived neurotrophic factor (BDNF) were assessed. Additional analyses were conducted in subgroups of clinical interest.ResultsWomen had a median (25th–75th percentiles) age of 58 (51–65) years, body mass index 33.5 (29.0–38.3) kg/m2, and AHI 33.3 (22.8–49.3). No differences were found between groups in the baseline levels of the biomarkers. After 12 weeks of follow-up, there were no changes between groups in any of the biomarkers assessed. These results did not change when the analyses were restricted to sleepy women or to those with severe OSA. In women with CPAP use at least 5 hours per night, only TNFα levels decreased compared to the control group (−0.29 ± 1.1 vs −0.06 ± 0.53, intergroup difference −0.23 [95% CI = −0.03 to −0.50]; p = 0.043).ConclusionsTwelve weeks of CPAP therapy does not improve biomarkers of inflammation, antioxidant activity, or depression compared to conservative treatment in women with moderate-to-severe OSA.Trial RegistrationNCT02047071.

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