scholarly journals Danger signal uric acid is involved in ventilator-induced lung injury pathogenesis

Critical Care ◽  
2011 ◽  
Vol 15 (S1) ◽  
Author(s):  
M Kuipers ◽  
H Aslami ◽  
T Van der Poll ◽  
M Schultz ◽  
C Wieland
Keyword(s):  
Uric Acid ◽  
Lung Injury ◽  
Danger Signal ◽  
Ventilator Induced Lung Injury

Uric Acid Is a Danger Signal Activating NALP3 Inflammasome in Lung Injury Inflammation and Fibrosis.

2009 ◽  
Author(s):  
I Couillin ◽  
P Gasse ◽  
N Riteau ◽  
J Tschopp ◽  
VF Quesniaux ◽  
...  
Keyword(s):  
Uric Acid ◽  
Lung Injury ◽  
Danger Signal ◽  
Nalp3 Inflammasome

Uric acid is a danger signal activating NALP3 inflammasome in lung injury inflammation and fibrosis

2008 ◽  
Vol 25 (9) ◽  
pp. 1191 ◽  
Author(s):  
P. Gasse ◽  
N. Riteau ◽  
V. Pétrilli ◽  
J. Tschopp ◽  
V. Lagente ◽  
...  
Keyword(s):  
Uric Acid ◽  
Lung Injury ◽  
Danger Signal ◽  
Nalp3 Inflammasome

Uric Acid Is a Danger Signal Activating NALP3 Inflammasome in Lung Injury Inflammation and Fibrosis

2009 ◽  
Vol 179 (10) ◽  
pp. 903-913 ◽  
Author(s):  
Pamela Gasse ◽  
Nicolas Riteau ◽  
Sabine Charron ◽  
Sandra Girre ◽  
Lizette Fick ◽  
...  
Keyword(s):  
Uric Acid ◽  
Lung Injury ◽  
Danger Signal ◽  
Nalp3 Inflammasome

Ventilator-induced lung injury

2003 ◽  
Vol 9 (3) ◽  
pp. 343-362 ◽  
Author(s):  
A ADAMS ◽  
D SIMONSON ◽  
D DRIES
Keyword(s):  
Lung Injury ◽  
Ventilator Induced Lung Injury

Dosisabhängige Beeinflussung vaskulärer Permeabilität im Ventilator-induced lung injury durch den Sphingosin 1- Phosphat Rezeptor Agonisten FTY720

Pneumologie ◽  
2009 ◽  
Vol 63 (02) ◽  
Author(s):  
HC Mueller ◽  
A Hocke ◽  
H Peters ◽  
B Gutbier ◽  
SM Kube ◽  
...  
Keyword(s):  
Lung Injury ◽  
Ventilator Induced Lung Injury

The circadian clock modulates susceptibility of mice to ventilator-induced lung injury

Pneumologie ◽  
2018 ◽  
Vol 72 (S 01) ◽  
pp. S10-S11
Author(s):  
M Felten ◽  
LG Teixeira Alves ◽  
C Chaput ◽  
E Letsiou ◽  
N Suttorp ◽  
...  
Keyword(s):  
Lung Injury ◽  
Circadian Clock ◽  
Ventilator Induced Lung Injury

scholarly journals Simultaneous Pretreatment of Aspirin and Omega-3 Fatty Acid Attenuates Nuclear Factor-κB Activation in a Murine Model with Ventilator-Induced Lung Injury

Nutrients ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 2258
Author(s):  
Won-Gun Kwack ◽  
Yoon-Je Lee ◽  
Eun-Young Eo ◽  
Jin-Haeng Chung ◽  
Jae-Ho Lee ◽  
...  
Keyword(s):  
Mechanical Ventilation ◽  
Fatty Acid ◽  
Lung Injury ◽  
Nuclear Factor Κb ◽  
Nuclear Factor ◽  
Omega 3 ◽  
Omega 3 Fatty Acid ◽  
Ventilator Induced Lung Injury ◽  
Sequential Administration ◽  
Pretreated Group

Ventilator-induced lung injury (VILI) is an important critical care complication. Nuclear factor-κB (NF-κB) activation, a critical signaling event in the inflammatory response, has been implicated in the tracking of the lung injury. The present study aimed to determine the effect of simultaneous pretreatment with enteral aspirin and omega-3 fatty acid on lung injury in a murine VILI model. We compared the lung inflammation after the sequential administration of lipopolysaccharides and mechanical ventilation between the pretreated simultaneous enteral aspirin and omega-3 fatty acid group and the non-pretreatment group, by quantifying NF-κB activation using an in vivo imaging system to detect bioluminescence signals. The pretreated group with enteral aspirin and omega-3 fatty acid exhibited a smaller elevation of bioluminescence signals than the non-pretreated group (p = 0.039). Compared to the non-pretreated group, the pretreatment group with simultaneous enteral aspirin and omega-3 fatty acid showed reduced expression of the pro-inflammatory cytokine, tumor necrosis factor-α, in bronchoalveolar lavage fluid (p = 0.038). Histopathological lung injury scores were also lower in the pretreatment groups compared to the only injury group. Simultaneous pretreatment with enteral administration of aspirin and omega-3 fatty acid could be a prevention method for VILI in patients with impending mechanical ventilation therapy.

Sign in / Sign up

Export Citation Format

Share Document