scholarly journals Non-obstructive idiopathic azoospermia vs azoospermia with antecedents of cryptorchidism: ways and probabilities of becoming parents

2021 ◽  
Vol 31 (1) ◽  
Author(s):  
Jacques Singh Sangwan ◽  
Claire Petit ◽  
Romane Sainte Rose ◽  
Cynthia Frapsauce ◽  
Laura Dijols ◽  
...  
Keyword(s):  
Testicular Sperm Extraction ◽  
Obstructive Azoospermia ◽  
Sperm Donation ◽  
Testicular Sperm ◽  
Embryo Donation ◽  
History Of ◽  
Group 2 ◽  
Sperm Freezing ◽  
Group 1

Abstract Background Non-obstructive azoospermia (NOA) with history of cryptorchidism and idiopathic NOA are the most common forms of NOA without genetic aetiology. Of all patients with one of these two types of NOA, only a few will have a positive TEsticular Sperm Extraction (TESE). Of those with positive extraction followed by sperm freezing, not all will have a child after TESE-ICSI. What are the ways and probabilities of taking home a baby for patients with NOA and a history of cryptorchidism compared with patients with idiopathic NOA? Results Patients with idiopathic NOA or NOA and a history of cryptorchidism who underwent their first TESE were included. The patients were divided into two groups: Group 1 was composed of 125 patients with idiopathic NOA and Group 2 of 55 patients with NOA and a history of surgically treated cryptorchidism. Our results showed that more than half of the NOA patients succeeded in becoming parents. The main way to fulfil their plans for parenthood is to use sperm or embryo donation (72%) for men with idiopathic NOA, whereas the majority of men with NOA and a history of cryptorchidism had a child after TESE-ICSI (58.8%). Conclusions In our centre, before considering TESE for a patient with NOA, we explain systematically TESE-ICSI alternatives (sperm donation, embryo donation or adoption). As a result, the couple can consider each solution to become parents.

scholarly journals PD05-07 TESTICULAR SPERM EXTRACTION FOR TREATMENT OF NON-OBSTRUCTIVE AZOOSPERMIA IN MEN WITH HISTORY OF CRYPTORCHIDISM

2016 ◽  
Vol 195 (4S) ◽  
Author(s):  
Phil Bach ◽  
Bobby Najari ◽  
Filipe Tenorio Lira Neto ◽  
Gianpiero Palermo ◽  
Nikica Zaninovic ◽  
...  
Keyword(s):  
Testicular Sperm Extraction ◽  
Obstructive Azoospermia ◽  
Testicular Sperm ◽  
History Of

scholarly journals Predictive factors of successful salvage microdissection testicular sperm extraction (mTESE) after failed mTESE in patients with non-obstructive azoospermia: Long-term experience at a single institute

2018 ◽  
Vol 90 (2) ◽  
pp. 136 ◽  
Author(s):  
Cem Yücel ◽  
Salih Budak ◽  
Mehmet Zeynel Keskin ◽  
Erdem Kisa ◽  
Zafer Kozacioglu
Keyword(s):  
Testicular Sperm Extraction ◽  
Obstructive Azoospermia ◽  
Testicular Sperm ◽  
Sperm Retrieval ◽  
Retrieval Rate ◽  
Significant Difference ◽  
History Of ◽  
The Mean ◽  
Long Term Experience

Objective: To observe the clinical practice of salvage microdissection testicular sperm extraction (mTESE) in patients with non-obstructive azoospermia (NOA) and to determine the factors that may predict the presence of spermatozoa in preoperative salvage mTESE. Methods: We retrospectively reviewed the medical records of 445 patients with the diagnosis of NOA, who had undergone the mTESE operation consecutively in our institution between the dates of March 2008 and June 2017. The study included a total of 49 patients with failure to detect spermatozoa in the first mTESE and who had then undergone salvage mTESE. In order to investigate the factors that predict the result of salvage mTESE, the patients were classified into two groups according to the outcome of salvage mTESE, as those with and without spermatozoa retrieval. Patients in these two groups were compared with regard to age, body mass index, history of varicocele, history of cryptorchidism, duration of infertility, outcomes of genetic analysis, results of hormone profiles and the testicular histopathology results of the first mTESE. Results: The sperm retrieval rate following salvage mTESE was observed to be 42.8%. Statistically a significant difference was determined between the mean follicle stimulating hormone (FSH) values of the groups (p = 0.013). No significant difference was observed between the groups with regard to the remaining parameters.Conclusion: It was observed that among the factors that predict the success of sperm retrieval in salvage mTESE in patients with NOA and previous unsuccessful sperm retrieval in mTESE operation, only the pre-operative FSH level was observed to significantly correlate with the success in salvage mTESE.

scholarly journals MP44-17 THE OUTCOME OF TESTICULAR SPERM EXTRACTION IN PATIENTS WITH NON-OBSTRUCTIVE AZOOSPERMIA WITH A HISTORY OF UNDESCENDED TESTIS

2020 ◽  
Vol 203 ◽  
pp. e662-e663
Author(s):  
Mazhar Ortaç ◽  
Şenol Tonyalõ ◽  
Nusret can Cilesiz ◽  
Metin Savun ◽  
Ateş Kadıoglu
Keyword(s):  
Undescended Testis ◽  
Testicular Sperm Extraction ◽  
Obstructive Azoospermia ◽  
Testicular Sperm ◽  
History Of

scholarly journals Prediction Models for Successful Sperm Retrieval in Patients with Non-Obstructive Azoospermia Undergoing Microdissection Testicular Sperm Extraction: Is There Any Room for Further Studies?

2021 ◽  
Vol 10 (23) ◽  
pp. 5538
Author(s):  
Ettore Caroppo ◽  
Giovanni Maria Colpi
Keyword(s):  
Prediction Accuracy ◽  
Prediction Models ◽  
Noncoding Rnas ◽  
Testicular Sperm Extraction ◽  
Obstructive Azoospermia ◽  
Testicular Sperm ◽  
Sperm Retrieval ◽  
Azfc Deletion ◽  
The Past ◽  
History Of

Several prediction models for successful sperm retrieval (SSR) in patients with azoospermia due to spermatogenic dysfunction (also termed non-obstructive azoospermia—NOA) have been developed and published in the past years, however their resulting prediction accuracy has never been strong enough to translate their results in the clinical practice. This notwithstanding, the number of prediction models being proposed in this field is growing. We have reviewed the available evidence and found that, although patients with complete AZFc deletion or a history of cryptorchidism may have better probability of SSR compared to those with idiopathic NOA, no clinical or laboratory marker is able to determine whether a patient with NOA should or should not undergo microdissection testicular sperm extraction (mTESE) to have his testicular sperm retrieved. Further research is warranted to confirm the utility of evaluating the expression of noncoding RNAs in the seminal plasma, to individuate patients with NOA with higher probability of SSR.

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