scholarly journals Prediction of plant-derived xenomiRs from plant miRNA sequences using random forest and one-dimensional convolutional neural network models

BMC Genomics ◽  
2018 ◽  
Vol 19 (1) ◽  
Author(s):  
Qi Zhao ◽  
Qian Mao ◽  
Zheng Zhao ◽  
Tongyi Dou ◽  
Zhiguo Wang ◽  
...  
2018 ◽  
Author(s):  
Qi Zhao ◽  
Qian Mao ◽  
Zheng Zhao ◽  
Tongyi Dou ◽  
Zhiguo Wang ◽  
...  

AbstractBackgroundAn increasing number of studies reported that exogenous miRNAs (xenomiRs) can be detected in animal bodies, however, some others reported negative results. Some attributed this divergence to the selective absorption of plant-derived xenomiRs by animals.ResultsHere, we analyzed 166 plant-derived xenomiRs reported in our previous study and 942 non-xenomiRs extracted from miRNA expression profiles of four species of commonly consumed plants. Employing statistics analysis and cluster analysis, our study revealed the potential sequence specificity of plant-derived xenomiRs. Furthermore, a random forest model and a one-dimensional convolutional neural network model were trained using miRNA sequence features and raw miRNA sequences respectively and then employed to predict unlabeled plant miRNAs in miRBase. A total of 241 possible plant-derived xenomiRs were predicted by both models. Finally, the potential functions of these possible plant-derived xenomiRs along with our previously reported ones in human body were analyzed.ConclusionsOur study, for the first time, presents the systematic plant-derived xenomiR sequences analysis and provides evidence for selective absorption of plant miRNA by human body, which could facilitate the future investigation about the mechanisms underlying the transference of plant-derived xenomiR.


2021 ◽  
Vol 2095 (1) ◽  
pp. 012069
Author(s):  
Lishan Zhang ◽  
Lei Han ◽  
Yuzhen Meng ◽  
Wenkui Zhao

Abstract Convolutional neural network used in fault diagnosis can effectively extract fault features in vibration signals. However, in the feature extraction of mechanical fault diagnosis, usually more than two feature signals including at least axial and radial vibration signals can be extracted. This paper proposes two multi-input convolutional neural network models based on the fault data of the aircraft hydraulic pump including axial and radial vibration. The first is the Independent Input Multi-input Convolutional Neural Network model. The two inputs are respectively used for convolution pooling operation with CNN, and are combined through the concatenate function before the fully connected layer, and then all frames are integrated and flattened by the flatten function. A one-dimensional array, finally enters the fully connected layer and outputs the result through the softmax function. The second is the Combined Input Multiinput Convolutional Neural Network, that is, combine two one-dimensional signals into a twodimensional signal in the input layer of the convolutional neural network and then perform convolution pooling, and finally output the result through the softmax function. The results show that the two models have good accuracy and stability, and the second one has a higher convergence and fitting efficiency than the first one.


2020 ◽  
Vol 3 (1) ◽  
pp. 362-372
Author(s):  
Svitlana Antoshchuk ◽  
Oksana Babilunha ◽  
Thanh Tran Kim ◽  
Anatolii Nikolenko ◽  
Tien Nguyen Thi Khanh

2021 ◽  
Vol 1074 (1) ◽  
pp. 012025
Author(s):  
A Poornima ◽  
M Shyamala Devi ◽  
M Sumithra ◽  
Mullaguri Venkata Bharath ◽  
Swathi ◽  
...  

IEEE Access ◽  
2021 ◽  
Vol 9 ◽  
pp. 45993-45999
Author(s):  
Ung Yang ◽  
Seungwon Oh ◽  
Seung Gon Wi ◽  
Bok-Rye Lee ◽  
Sang-Hyun Lee ◽  
...  

Author(s):  
Robert J. O’Shea ◽  
Amy Rose Sharkey ◽  
Gary J. R. Cook ◽  
Vicky Goh

Abstract Objectives To perform a systematic review of design and reporting of imaging studies applying convolutional neural network models for radiological cancer diagnosis. Methods A comprehensive search of PUBMED, EMBASE, MEDLINE and SCOPUS was performed for published studies applying convolutional neural network models to radiological cancer diagnosis from January 1, 2016, to August 1, 2020. Two independent reviewers measured compliance with the Checklist for Artificial Intelligence in Medical Imaging (CLAIM). Compliance was defined as the proportion of applicable CLAIM items satisfied. Results One hundred eighty-six of 655 screened studies were included. Many studies did not meet the criteria for current design and reporting guidelines. Twenty-seven percent of studies documented eligibility criteria for their data (50/186, 95% CI 21–34%), 31% reported demographics for their study population (58/186, 95% CI 25–39%) and 49% of studies assessed model performance on test data partitions (91/186, 95% CI 42–57%). Median CLAIM compliance was 0.40 (IQR 0.33–0.49). Compliance correlated positively with publication year (ρ = 0.15, p = .04) and journal H-index (ρ = 0.27, p < .001). Clinical journals demonstrated higher mean compliance than technical journals (0.44 vs. 0.37, p < .001). Conclusions Our findings highlight opportunities for improved design and reporting of convolutional neural network research for radiological cancer diagnosis. Key Points • Imaging studies applying convolutional neural networks (CNNs) for cancer diagnosis frequently omit key clinical information including eligibility criteria and population demographics. • Fewer than half of imaging studies assessed model performance on explicitly unobserved test data partitions. • Design and reporting standards have improved in CNN research for radiological cancer diagnosis, though many opportunities remain for further progress.


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