The clinical effect of dexmedetomidine combined with parecoxib sodium on sedation, antianxiety and prevention of intubation stress in patients undergoing functional endoscopic sinus surgery: a randomised controlled trial

AbstractObjective:To compare the efficacy of two modes of delivery of information for patients undergoing functional endoscopic sinus surgery: website and printed leaflet.Methods:A two-centre, prospective, single-blinded, randomised, controlled trial was conducted, comparing mode of information delivery. Adult patients were randomly allocated to receive pre-operative information regarding functional endoscopic sinus surgery, either via a website or a printed leaflet. Primary outcomes, measured by questionnaire, were: readability, usability and recall of complications.Results:Fifty-eight patients were recruited. Fifty met the inclusion criteria, of which 40 were analysed in the study (20 patients per group), meeting the power criteria set. There were 18 male and 22 female patients, ranging in age from 21 to 76 years (mean, 47 years). Patients found both the printed leaflet and the website readable, and were satisfied with the usability of both modes. There were similar rates for recall of complications in both study arms.Conclusion:Patient information on functional endoscopic sinus surgery can be provided either as a printed leaflet or a website, with similar rates for usability, readability and recall of complications. These findings could help tailor the provision of pre-operative information for patients undergoing functional endoscopic sinus surgery, based on patient preference.

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Effects of preconditioning by nasal splint and mouth breathing on emergence delirium after functional endoscopic sinus surgery in Chinese adults: a study protocol for a randomised controlled trial

BMJ Open ◽

10.1136/bmjopen-2019-033803 ◽

2020 ◽

Vol 10 (8) ◽

pp. e033803

Author(s):

Hongjiao Xu ◽

Xiang Li ◽

Bin Yang ◽

Zhenyuan Shen ◽

Weiwen Li ◽

...

Keyword(s):

Randomised Controlled Trial ◽

Endoscopic Sinus Surgery ◽

Controlled Trial ◽

Original Data ◽

Functional Endoscopic Sinus Surgery ◽

Mouth Breathing ◽

Sinus Surgery ◽

Breathing Training ◽

Nasal Splint ◽

Randomised Controlled

IntroductionEmergence delirium (ED) is a common adverse manifestation after general anaesthesia and may result in undesirable consequences. Its causes and mechanisms are diverse and complex, and it is still unavoidable in clinical work. There is a high incidence of ED after otorhinolaryngology surgery, which may result from the sudden loss of functional senses and discomfort of surgical organs. This study aims to test a non-invasive, non-drug treatment modality of nose clamping and mouth-breathing training before surgery to reduce ED.Methods and analysisThis prospective randomised controlled trial (RCT) will include 200 patients who undergo functional endoscopic sinus surgery (FESS) at Shanghai General Hospital, China. Study participants will be randomly assigned in two groups with a 1:1 ratio. The pretreatment group (P-group) will receive an intervention by nasal splint and mouth-breathing training before surgery, while the control group (C-group) will not receive any intervention; following which both groups will undergo FESS under general anaesthesia in accordance with the same anaesthesia scheme. After surgery, we will perform a single-blinded assessment of ED occurrence with stratification. IBM SPSS Statistics V.20 statistical software will be used for statistical analyses. A X2 test will be used to compare the two groups, and t-tests will determine the statistical significance of continuous variables.Ethics and disseminationThis RCT was designed in accordance with the principles of the Declaration of Helsinki and has been approved by the Ethics Committee of Shanghai General Hospital, ID: 2019KY039.We expect to release the original data in February 2022 on the ResMan original data sharing platform (IPD sharing platform) of the China clinical trial registry, which can be viewed at the following website:http://www.medresman.org.cn/pub/cn/proj/projectshow.aspx?proj=6293.Trial registration numberChiCTR1900024925

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