scholarly journals Acquired nasolacrimal duct obstruction: clinical and histological findings of 275 cases

2022 ◽  
Vol 22 (1) ◽  
Author(s):  
Almantas Makselis ◽  
Donatas Petroska ◽  
Aiste Kadziauskiene ◽  
Ruta Jaruseviciene ◽  
Andrius Ruzgys ◽  
...  
Keyword(s):  
B Cell ◽  
Cell Lymphoma ◽  
B Cell Lymphoma ◽  
Nasolacrimal Duct ◽  
Nasolacrimal Duct Obstruction ◽  
Common Finding ◽  
Purulent Discharge ◽  
Histological Findings ◽  
Lacrimal Sac ◽  
Duct Obstruction

Abstract Background Acquired nasolacrimal duct obstruction is a blockage of the lacrimal outflow system usually caused by local nonspecific inflammation of the lacrimal sac and the nasolacrimal duct. However, cases exist where the primary nasolacrimal system obstruction is caused by malignancies. Our aim was to investigate lacrimal sac pathologies in patients with acquired nasolacrimal duct obstruction and compare their clinical manifestations. Methods This retrospective clinical study included 275 patients with acquired nasolacrimal duct obstruction who underwent external dacryocystorhinostomy and lacrimal sac biopsy. Cases were classified into tumor or nonspecific pathology groups and subdivided according to the level of inflammation. Histological and clinical data were analyzed. Results Three tumors (1.1%) (an adenoid cystic carcinoma, an eccrine spiradenoma and small B cell lymphoma) were diagnosed. Chronic nongranulomatous inflammation was the most common histological finding, corresponding to 194 cases (70.5%). The other 81 (29.5%) were subacute, acute forms of nongranulomatous inflammation, tumors and fibrosis cases. Epiphora with continuous purulent discharge was the most common clinical sign reported by 144 (52.4%) patients, and two (0.7%) patients had a palpable mass near the medial canthal tendon, which was identified as an eccrine spiradenoma and small B cell lymphoma. There was no significant difference in the clinical symptoms, duration or case history between the nonspecific pathology and tumor groups (p = 0.292). Conclusions Chronic nongranulomatous inflammation of the lacrimal sac was the most common finding among acquired nasolacrimal duct obstruction cases. There were no associations between the histological findings and clinical presentation. The authors recommend a lacrimal sac biopsy only in cases when a tumor is clinically suspected.

scholarly journals Acquired Nasolacrimal Duct Obstruction: Clinical and Histological Findings of 275 Cases

2021 ◽  
Author(s):  
Almantas Makselis ◽  
Donatas Petroska ◽  
Aiste Kadziauskiene ◽  
Ruta Jaruseviciene ◽  
Andrius Ruzgys ◽  
...  
Keyword(s):  
B Cell ◽  
Cell Lymphoma ◽  
Granulomatous Inflammation ◽  
B Cell Lymphoma ◽  
Nasolacrimal Duct ◽  
Nasolacrimal Duct Obstruction ◽  
Purulent Discharge ◽  
Histological Findings ◽  
Lacrimal Sac ◽  
Duct Obstruction

Abstract Background: Acquired nasolacrimal duct obstruction is a blockage of the lacrimal outflow system usually caused by a local non-specific inflammation of the lacrimal sac and the nasolacrimal duct. However, cases exist where the primary nasolacrimal system obstruction was caused by malignancies. Our aim was to investigate lacrimal sac pathologies in patients with acquired nasolacrimal duct obstruction and compare its clinical manifestations. Methods: The retrospective clinical study included 275 cases with acquired nasolacrimal duct obstruction who underwent external dacryocystorhinostomy and lacrimal sac biopsy. Cases were classified into tumor or non-specific pathology groups subdivided according to the level of inflammation. Histological and clinical data were analyzed.Results: Three tumors (1.1%) (adenoid cystic carcinoma, eccrine spiradenoma and small B cell lymphoma) were diagnosed. Chronic non-granulomatous inflammation was the most common histological finding, corresponding to 194 cases (70.5%). Other 81 (29.5%) were subacute, chronic forms of non-granulomatous inflammation, tumor and fibrosis cases. Epiphora with continuous purulent discharge was the most common clinical sign reported by 144 (52.4%) patients, two (0.7%) patients had a palpable mass near the medial canthal tendon, which were identified as an eccrine spiradenoma and small B cell lymphoma. There was no significant difference in the clinical symptoms, its’ duration or case history between the non-specific pathology and the tumor groups (p = 0.292). Conclusions: Chronic non-granulomatous inflammation of the lacrimal sac was the most frequent etiology of acquired nasolacrimal duct obstruction. There were no associations between the histological findings and clinical presentation. The authors recommend a lacrimal sac biopsy only in cases when a tumor is clinically suspected.

Lacrimal sac lymphoma: A series of Japanese patients

2018 ◽  
Vol 29 (6) ◽  
pp. 678-684 ◽  
Author(s):  
Maria Suzanne Sabundayo ◽  
Yasuhiro Takahashi ◽  
Hirohiko Kakizaki
Keyword(s):  
B Cell ◽  
Cell Lymphoma ◽  
Case Series ◽  
B Cell Lymphoma ◽  
Japanese Patients ◽  
Nasolacrimal Duct ◽  
Lacrimal Sac ◽  
Retrospective Case ◽  
Large B Cell Lymphoma ◽  
Large B Cell

Purpose: To present cases of primary lacrimal sac lymphoma in a Japanese population. Methods: In this retrospective case series, five cases (two males and three females; mean age: 49.8 years; age range: 38–62 years) were included. Clinical features, diagnostic findings, and treatment outcomes were collected and reviewed. Results: Most patients presented with a swelling or mass in the medial canthal area. Only one patient presented with epiphora, while another patient also complained of pain which was due to inflammation. Imaging studies revealed a lacrimal sac mass with involvement of the nasolacrimal duct and variable involvement of the nasal cavity. Histopathological findings revealed three cases of diffuse large B-cell lymphoma, one case of extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue, and one case of follicular lymphoma. Four cases were treated with a combination of chemotherapy and immunotherapy, with one case necessitating additional radiotherapy. One case was treated with immunotherapy alone. The mean follow-up was 23 (range: 3–50) months. Four cases showed complete remission, while the remaining patient is still ongoing treatment. Conclusion: Diffuse large B-cell lymphoma is the most common type of lacrimal sac lymphoma in this series. Lacrimal sac tumors should be ruled out in the presence of epiphora, dacryocystitis, or a mass in the medial canthus, even in the absence of pain or bleeding. Combined chemotherapy and immunotherapy is an effective treatment for these cases.

Functional metagenomic profile of the lacrimal sac microbial communities in primary acquired nasolacrimal duct obstruction: The Lacriome paper 2

2021 ◽  
pp. 112067212110640
Author(s):  
Mohammad Javed Ali
Keyword(s):  
Functional Analysis ◽  
Microbial Communities ◽  
Cell Structure ◽  
Tertiary Care ◽  
Nasolacrimal Duct ◽  
Ecosystem Dynamics ◽  
Nasolacrimal Duct Obstruction ◽  
Lacrimal Sac ◽  
Duct Obstruction ◽  
Information Processes

Purpose To study the functional metagenomic profile of the microbes isolated from the lacrimal sac of patients with primary acquired nasolacrimal duct obstruction. Methods A prospective study was performed on 10 consecutive lacrimal sac samples obtained for the metagenomic analysis from patients with primary acquired nasolacrimal duct obstruction ( who underwent endoscopic dacryocystorhinostomy at a tertiary care Dacryology service. The samples were collected intraoperatively soon after a full-length lacrimal sac marsupialization and immediately transported on ice to the laboratory. Following DNA extraction and library preparation, a whole shotgun metagenome sequencing was performed on the Illumina NOVASEQ 6000TM platform. The downstream processing and bioinformatics of the samples were performed using multiple software packaged in SqueezeMetaTM pipeline and functional analysis using the MG-RASTTM pipeline. Results The microbial gene mapping and protein prediction demonstrated proteins with known functions to range from 66.41% to 84.03% across the samples. The functional category distribution of Kyoto Encyclopedia of Genes and Genomes ortholog (level 1 data) showed metabolism to be the most commonly involved function followed by environmental information processes, genetic information processes and cellular processes. The functional subsystem profiling demonstrated genes associated with carbohydrate, protein and RNA metabolism, Amino acids and their derivatives, cofactors and prosthetic groups and factors involved in cell structure regulation and cell cycle control. Conclusion This is the first functional metagenomic profile of the lacrimal sac microbiota from patients with primary acquired nasolacrimal duct obstruction. Functional analysis has provided newer insights into the ecosystem dynamics and strategies of microbial communities inhabiting the lacrimal sac. Further Lacriome studies may provide clues for better understanding of the disease etiopathogenesis.

Relationship between lacrimal sac size and duration of tearing in nasolacrimal duct obstruction

2019 ◽  
Vol 54 (1) ◽  
pp. 111-115 ◽  
Author(s):  
Min Joung Lee ◽  
In Hyuk Kim ◽  
Youn Joo Choi ◽  
Namju Kim ◽  
Ho-Kyung Choung ◽  
...  
Keyword(s):  
Nasolacrimal Duct ◽  
Nasolacrimal Duct Obstruction ◽  
Lacrimal Sac ◽  
Duct Obstruction
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