ENDOSCOPIC ENDONASAL DACRYOCYSTORHINOSTOMY: EXPERIENCE OF HUNDRED CASES

Objective: To determine the success rate of Endonasal Endoscopic Dacryocystorhinostomy (Endo-DCR) in cases of chronic dacryocystitis secondary to primary acquired nasolacrimal duct obstruction (NLDO). Study Design: Quasi-experimental study. Place and Duration of Study: Department of Oculoplastic Surgery, Armed Forces Institute of Ophthalmology Rawalpindi, from Sep 2018 to Nov 2019. Methodology: Endo-DCR under General Anaesthesia was performed on 100 patients of primary acquired nasolacrimal duct obstruction causing chronic dacryocystitis. Post-operatively these patients were checked on first post-op day, then on one week and finally four months after surgery. We removed silicone tubes of all the patients four months after surgery. To ensure patency of lacrimal passage, we did syringing and irrigation of lacrimal system of all cases, at conclusion of the study. We chose absence of epiphora and patent lacrimal system on syringing as indicators of successful procedure. Results: Hundred patients (males 37; females 63) were recruited for this study. Mean age of our sample population was 51.1 ± 29 years. Right nasolacrimal duct obstruction cases were 56 whereas left nasolacrimal duct obstruction cases were 44. Subjective improvement i.e., absence of epiphora was found in 90% patients. We got successful irrigation of lacrimal passages (objective improvement) in 94% of patients. Conclusion: Endo-DCR yields comparable results to external Dacryocystorhinostomy (Ex DCR). It offers additional benefits of esthetically better outcome, lesser complication rate and short surgery and patient recovery time.

Features of the Postoperative Period in Patients with Chronic Dacryocystitis and Type 2 Diabetes Mellitus after Endoscopic Endonasal Dacryocystorhinostomy Depending on the Degree of Compensation of Diabetes Mellitus

The aim. To identify the features of the postoperative period in patients with chronic dacryocystitis and type 2 diabetes mellitus (DM2) after endoscopic endonasal dacryocystorhinostomy (DCR), depending on the degree of compensation of DM. Materials and methods. The study involved 30 DM2 patients with chronic dacryocystitis who underwent endoscopic endonasal DCR according to standard methods. The patients were divided into groups according to the degree of compensation of DM2: 6 patients with compensated, 7 patients with subcompensated and 17 patients with decompensated DM2. The results of the operation were evaluated after 2 months, 6 months and 2 years. In addition to standard methods, ophthalmic examination included nasolacrimal duct probing, lacrimal duct lavage, and endoscopic examination of the nasal cavity. Results and discussion. The efficiency of endoscopic endonasal DCR in decompensated DM2 after 2 months (58.8 ± 11.9 % of patients) on average was 1.4 times, and after 6 months (52.9 ± 12.1 % of patients) and 2 years (41.2 ± 11,9 % of patients) – it was 1.5 times less than that in subcompensated and compensated DM2 (p < 0.05). In patients with decompensated DM2, tearing was observed in 41.2 ± 11.9 % of patients after 2 months, in 47.1 ± 12.1 % of patients after 6 months and in 58.8 ± 11.9 % of patients after 2 years post-op, which was, on average, 2.7 times, 2.1 times and 1.5 times more often than that in subcompensated and compensated DM2, respectively (p < 0.05); there were no significant differences between the values (p > 0.05). Conclusions. Features of the postoperative period in patients with chronic dacryocystitis after endoscopic endonasal DCR depend on the degree of compensation of DM2. The efficiency of endoscopic endonasal DCR in decompensated DM2 after 2 months is on average 1.4 times, and after 6 months and 2 years it is 1.5 times less than that in subcompensated and compensated DM2. Keywords: type 2 diabetes mellitus, degree of compensation of diabetes mellitus, chronic dacryocystitis, efficiency of endoscopic endonasal dacryocystorhinostomy, features of postoperative period.

The importance of clinical presentation on long-term outcomes of external dacryocystorhinostomies: Our experience on 245 cases

Purpose External dacryocystorhinostomy (EXT-DCR) is a surgical approach commonly used to treat post-canalicular acquired lacrimal obstruction whose success rate has been described, equally with endoscopic DCR, to be superior to other available treatments. Methods At San Raffaele Hospital, Milan (Italy), from January 2008 to December 2020, 245 EXT-DCRs were performed. All patients underwent routine pre-operative work-up including Jones tests and probing and irrigation of the lacrimal pathway; when necessary, a multidisciplinary approach with nasal endoscopy was performed. The surgical approach was followed by positioning of a bicanalicular stent which was left in place for 6 months. Success was defined as resolution of clinical signs/symptoms and free lacrimal flow on functional test. Results Of the cases enrolled, 26.9% were treated for recurrent epiphora (group 1), and 73.1% for epiphora associated with chronic dacryocystitis (group 2). After a median follow-up of 71 months, group 1 had success at T0 (1 month) and T1 (long-term) of 81.8% and 60.6%, respectively, compared to 93.8% and 77.7% in group 2. Statistical analysis showed a significant association with surgery both at T0 ( p = 0.018) and T1 ( p = 0.012) with group 2 showing better outcomes. Additionally, the cosmetic outcome of the external scar was defined as invisible in 91.8% of cases and slightly visible in 8.2%. Conclusions External dacryocystorhinostomy provides long-term reliable results particularly in case of chronic dacryocystitis. Moreover, the optimal esthetic outcome of the external scar should be no longer considered the only guiding principle of treatment modality, particularly in the elderly.

A case of severe corneal-conjunctival xerosis caused by long-term local use of inocaine in a patient with viral conjunctivitis (COVID-19)

The article describes a rare case of conjunctivitis in a 25-year-old patient that developed 5 days before the first typical signs of COVID-19 disease appeared, and led to cicatricial changes in the conjunctiva in the form of bilateral partial external symblepharon and mild dry eye syndrome, and later chronic dacryocystitis of the right eyes. Surgical treatment of simblepharon led to its relapse in the right eye with gradual development of severe DES with a significant decrease in visual acuity. The prescribed complex therapy with drops of dexamethasone, restasis, vitabact and tear-suppressing drugs (Oftagel, Vita Pos ointment) for several days, however, led to extensive detachment of the corneal epithelium and the development of a superficial ulcer of the right eye with a keratomalacia area in its lower part. In the process of inpatient treatment recommended to the patient at one of the councils, it suddenly turned out that the patient had been periodically instilling inocaine into his right eye for anesthesia for several months on his own. It was the decrease in sensitivity against the background of prolonged instillations of the local anesthetic inocaine that aggravated the violation of the stability of the tear film, led to a significant decrease in tear secretion and a cytotoxic effect, which gradually led to the development of severe corneal-conjunctival xerosis. The performed inpatient treatment and subsequent outpatient treatment led to the relief of inflammation, epithelialization of the ulcer. Key words: conjunctivitis, COVID-19, complication, simblefaron, inocaine anesthetic, corneal-conjunctival xerosis.

Endoscopic endonasal dacryocystorhinostomy-an experience in a tertiary care hospital

<p><strong>Background:</strong> Dacryocystorhinostomy is a surgical procedure by which the lacrimal flow is diverted into the nasal cavity by making an opening in the lacrimal sac when the nasolacrimal duct gets blocked. The operation can be carried out using either an external or endonasal surgical approach.</p><p><strong>Methods:</strong> This is a clinical observational study done on 50 patients with chronic dacryocystitis with obstruction at the level of sac or nasolacrimal duct. This study was conducted at Dr. Shankarrao Chavan government medical college, Nanded, during the period of 2 years (2018-2020). Patients were evaluated and operated for endoscopic endonasal dacryocystorhinostomy.</p><p class="Default"><strong>Results:</strong> The mean age of studied cases was 33.92±12.13 years. The M:F ratio was 0.78. Epiphora was the predominant complaint in all cases 100%. Swelling of lacrimal sac was present in 24% cases and Pain on affected side was present in 18% cases. 6% patients had fistula on the side of block. 12% patients had mucocele and 14% patients had pyocele on the affected side. Left and right side was involved in 54% and 40% cases respectively. The disease presented bilaterally in 06% cases. 80% patients had no complications after endonasal endoscopic dacryocystorhinostomy (EEDCR) surgery. Rate of surgical success was 92%.</p><p class="Default"><strong>Conclusions:</strong> Nasolacrimal duct obstruction is more common among females and in middle aged persons. EEDCR is treatment which provides patients relief from the symptoms without any scar and also preserves nasolacrimal pump system with high success rate. It may prove better surgical technique in chronic dacryocystitis.</p>

The Bacterial Profile and Microbial Susceptibility of Acute and Chronic Dacryocystitis in Matini Hospital, Kashan, Iran

Background: Recent studies have shown an increasing incidence of antibiotic resistance in dacryocystitis. Management of diseases may include determining microbial agents and choosing appropriate antibiotics for treatment. Objectives: This study aimed to present the best treatments for dacryocystitis. To this end, specimens' microbiology and antibiotic susceptibility were examined in patients with dacryocystitis in the microbiology laboratory of the Kashan University of Medical Sciences. Methods: This cross-sectional study was performed on 172 patients presenting with acute and chronic dacryocystitis at the Matini Hospital, Kashan, between 2017 - 2018. Patient characteristics, culture isolates, and antimicrobial susceptibility data were collected. The PCR assay of the mecA gene was performed in all methicillin-resistant Staphylococcus isolates. Results: The most common bacteria were coagulase-negative staphylococci (CoNS), Staphylococcus aureus, Pseudomonas aeruginosa, and Acinetobacter baumannii. The majority of the isolated microbes were sensitive to rifampicin, linezolid, amikacin, and gentamicin. In Gram-negative bacilli, nine of the isolates were extended-spectrum beta-lactamase positive. The PCR test showed the frequency of mecA gene of resistant S. aureus and resistant CoNS isolates to be 40 and 46.3%, respectively. Conclusions: Coagulase-negative staphylococci were the most frequently isolated bacteria. The highest antibiotic susceptibility was observed to rifampin, linezolid, amikacin, and gentamicin. A high percentage of CoNS carried the mecA gene.

Epidemiology, clinical profile, complications and treatment outcomes of chronic dacryocystitis in a tertiary care hospital in post lockdown era: An observational study

to study the epidemiological factors, clinical features, complications and treatment outcomes of chronic dacryocystitis in Odisha after nationwide lockdown in 2020. An observational study was designed from July 2020 to December 2020 in Regional Institute of Ophthalmology, Cuttack, Odisha. Total of 187 patients presenting with chronic dacryocystits were evaluated thoroughly in various epidemiological parameters. The history and clinical features were noted. After proper evaluation and conservative treatment, those patients were subjected for surgery and the surgical outcomes are followed-up upto 3 more months, i.e. March 2021.: The prevalence of chronic dacryocystitis was around 1.224%. Among the 187 patients, 112 were females (59.9%). The disease was found in highest proportion in the age group of 51-60 years (30.5%) followed by 25.7% in the age group of 61-70 years. 90.4% were from rural population. Socioeconomic status and living standard was found to be a significant factor, people belonging to class 4 & 3 were affected more. Majority of the affected were housewives (39.6%) and farmers (21.9%) followed by small businessmen (13.9%) and wage laborers (12.9%). Epiphora was the commonest presenting symptom in 71.6%, followed by mucopurulent discharge in 29.9% and swelling near the medial canthus in 12.3% cases. Complications like conjunctivitis, keratitis, preseptal cellulitis, cutaneous fistula were present in 6.4%, 8.4%, 7.5% and 5.9% cases respectively in our study group. The success rate of external DCR was reported as 85.8% in this study. Chronic Dacryocystitis, though a common problem of lacrimal drainage system, is much less recognized disease, specially in rural population and in lower socio-economic community in Odisha. Thus patients may present late with one or more complications, e.g. conjunctivitis, keratitis, preseptal cellulitis, lacrimal abscess, mucocele, cutaneous fistula, which is the current scenario in post-lockdown 2020 era. Maintaining all precautions and guidelines for COVID-19, we should not delay treating these patients with surgical measures. The surgical success rate (85.8%) however was not affected much in spite of all these factors.

Use of modern energetic methods of bone tissue removal during endoscopic dacryocystorhinostomy

The article presents the results of surgical treatment of 22 patients with chronic dacryocystitis accompanied by proximal obstruction of the nasolacrimal duct. A new method of nasolacrimal anastomosis bone window during endonasal endoscopic dacryocystorhinostomy using ultrasound bone dissection is described. The questions of operation technique using SONOCA 185 ultrasound bone dissector and specific features of postoperative treatment are discussed. The obtained data allow to conclude that low temperature process of bone dissection with ultrasound cavitation gives a possibility of adequate bone window formation, reduces surgical trauma of bone structures, surrounding soft tissues and nasal cavity vessels as well as reduces the risk of bleeding and operation time needed for its stopping. It also enables better healing of soft tissues in shorter terms, provides anatomical and functional success of operation in 91 % of cases. Key words: chronic dacryocystitis; endonasal endoscopic dacryocystorhinostomy; ultrasound bone dissection; dacryostoma.

Chronic Dacryocystitis: Clinico-Bacteriological Profile and its Antibiogram at a Tertiary care Hospital in Belagavi, Karnataka

Chronic dacryocystitis is an infection of the lacrimal sac and occurs due to obstruction of the nasolacrimal duct. It is an important cause of ocular morbidity in India. Objective: 1) To identify various species of aerobic bacteria causing chronic dacryocystitis 2) To determine the antibiotic sensitivity pattern of these bacterial species. At a tertiary care hospital in Belagavi, Karnataka, over two year period, a cross-sectional study was conducted among 60 patients suffering from chronic dacryocystitis. Samples obtained were subjected to microbiological culture and antibiotic sensitivity testing was done on identified isolates. Statistical analysis was done using Microsoft office excel 2010. The Maximum (31.67%) number of patients who belonged to the age group of 45-50 years Female were predominantly affected 50 (83.3%). Majority i.e. 53 (88.34%) had unilateral eye involvement. Of 67 samples collected 42 (62.68%) were culture positive. Gram-positive cocci (65.22%) were the predominant cause of bacterial infection than Gram-negative bacilli (34.78%). Among Gram-positive cocci, Staphylococcus aureus (30.43%) and Streptococcus pneumoniae (21.73%) and among Gram-negative bacilli. Pseudomonas aeruginosa and Klebsiella aerogenes (10.86% each) were the predominant isolates. The most effective antimicrobial agents for Gram-positive cocci were Gentamicin and Vancomycin (93.33% each) and for Gram-negative bacilli were Ticarcillin/Clavulanic acid (87.25%), Ticarcillin, Imipenem, and Ceftazidime/Clavulanic acid (81.25% each). The present study highlights the need for detection of specific etiological agents and their antibiotic sensitivity which will enable the clinician in efficient patient management and avoid irrational antibiotic use.