Effects of aerobic exercise on tear secretion and tear film stability in dry eye patients

Abstract Background To study the effects of aerobic exercise (AE) on tear secretion and tear film stability in dry eye patients. Methods This study consisted of two parts, each part included 3 groups, namely dry eye without AE group, dry eye with AE group and pre-clinical dry eye with AE group. In part 1, we studied the variations of Schirmer I test and six tear compositions before and after AE (34 eyes in each group). In part 2, we studied the variations of tear meniscus height, first and average non-invasive tear breakup time (F-NITBUT and A-NITBUT), lipid layer thickness, number of incomplete and complete blinks, partial blink rate (PBR) and visual acuity before and after AE (30 eyes in each group). Results In dry eye with AE group, Schirmer I test at 0 min after AE increased significantly compared to baseline (P < 0.001), the oxidative stress marker 8-hydroxy-2′-deoxyguanosine after AE decreased significantly compared to baseline (P = 0.035, P = 0.045), F-NITBUT and A-NITBUT after AE prolonged significantly compared to baseline (P < 0.001, P = 0.007, P = 0.036; P < 0.001, P = 0.001, P = 0.044), number of incomplete blinks and PBR at 10 min after AE decreased significantly compared to baseline (P < 0.001; P < 0.001) while number of complete blinks increased significantly (P < 0.001). Besides, significant differences were also found between dry eye with AE group and dry eye without AE group at all above corresponding time point (P < 0.05). Conclusion AE promotes tear secretion and improves tear film stability in dry eye patients. AE may be a potential treatment for dry eye. Trial registration Chinese Clinical Trial Registry, ChiCTR2000038673. Registered 27 September 2020,

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Effects of Aerobic Exercise on Tear Secretion and Tear Film Stability in Dry Eye Patients

10.21203/rs.3.rs-294144/v1 ◽

2021 ◽

Author(s):

Chao Sun ◽

Xiaofan Chen ◽

Yanming Huang ◽

Huan Zou ◽

Wei Fan ◽

...

Keyword(s):

Visual Acuity ◽

Aerobic Exercise ◽

Dry Eye ◽

Tear Film ◽

Normal Subjects ◽

Oxidative Stress Marker ◽

Film Stability ◽

Tear Secretion ◽

Tear Film Stability ◽

Before And After

Abstract Background: To study the effects of aerobic exercise (AE) on tear secretion and tear film stability in dry eye patients.Methods: Firstly we observed Schirmer Ⅰ test and 6 tear compositions detected by ELISA in 34 eyes of dry eye patients and 34 eyes of normal subjects before and after AE. Then we observed 30 eyes of dry eye patients and 30 eyes of normal subjects before and after AE, the evaluated variables included tear meniscus height (TMH), first and average non-invasive tear breakup time (F-NITBUT and A-NITBUT), lipid layer thickness (LLT), number of incomplete and complete blinks, partial blink rate (PBR) and visual acuity.Results: In dry eye group, compared with baseline, Schirmer Ⅰ test at 0 minutes after AE increased significantly (P < 0.001), F-NITBUT and A-NITBUT at every time point after AE prolonged significantly (P < 0.001, P = 0.007, P = 0.036; P < 0.001, P = 0.001, P = 0.044), number of incomplete blinks and PBR at 10 minutes after AE decreased significantly (P < 0.001; P < 0.001) while number of complete blinks increased significantly (P < 0.001), visual acuity at 10 and 20 minutes after AE improved significantly (P = 0.017, P = 0.021). The overall oxidative stress marker 8-hydroxy-2’-deoxyguanosine at 0 minutes after AE decreased significantly compared with baseline (P = 0.040).Conclusion: AE promotes tear secretion and improves tear film stability in dry eye patients. AE may be a potential treatment for dry eye.Trial registration: Chinese Clinical Trial Registry, ChiCTR2000038673. Registered 27 September 2020, http://www.chictr.org.cn/showproj.aspx?proj=57282

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Ocular Surface Disorders in a Group of Egyptian Children with End Stage Renal Failure on Dialysis: A Cross-Sectional Study

Journal of Ophthalmology ◽

10.1155/2016/4767819 ◽

2016 ◽

Vol 2016 ◽

pp. 1-7

Author(s):

Mohamed Anbar ◽

Ahmed R. H. Ahmed ◽

Abdel-Azeem M. El-Mazary ◽

Ramadan A. Mahmoud

Keyword(s):

Renal Failure ◽

Dry Eye ◽

Tear Film ◽

Film Stability ◽

End Stage Renal Failure ◽

Tear Secretion ◽

Tear Film Stability ◽

Eye Symptoms ◽

End Stage ◽

Dry Eye Symptoms

Purpose. To investigate tear function, ocular manifestations, and squamous metaplasia of the conjunctival epithelium (SMCE) in children with end stage renal failure (ESRF) on dialysis.Methods. Thirty children with ESRF and 20 age and sex matched controls during the period from January 2014 to May 2015 underwent full ophthalmologic examination and the tear function was investigated by the Schirmer and tear film break-up time (TBUT) tests. SMCE was evaluated by impression cytology and immunocytochemistry. The correlations of tear function status with ESRF-related clinical and biochemical variables were measured statistically.Results. Dry eye symptoms were detected in 26% of children with ESRF, compared with none of the controls (P=0.05) and SMCE was almost absent. Values of the Schirmer and TBUT tests were significantly lower in children with ESRF for right eye (t=24.63,P=0.01, andt=11.9,P=0.002, resp.) and left eye (t=24.7,P=0.02, andt=11.4,P=0.0004, resp.). TBUT and the Schirmer test values were correlated inversely with the duration of ESRF (R=-0.45,P=0.01, andR=-0.46,P=0.01, resp.) and with the duration of dialysis (R=-0.39,P=0.03, andR=-0.45,P=0.01, resp.). None of the following parameters was associated with distorted tear function including serum creatinine, electrolytes, parathyroid hormone, total protein, albumin, CBC parameters, and systolic or diastolic blood pressure.Conclusion. The basal tear secretion and tear film stability were lower while the dry eye symptoms such as itching and redness were more common among children with ESRF. The duration of ESRF and dialysis duration seem to be related to the disturbances in tear secretion and tear film stability. However, SMCE is very rare.

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Associations between dry eye symptoms with tear film stability, volume, and osmolarity in a sample of young adults in Kuala Lumpur

Sudanese Journal of Ophthalmology ◽

10.4103/sjopthal.sjopthal_14_18 ◽

2018 ◽

Vol 10 (1) ◽

pp. 32

Author(s):

Bariah Mohd-Ali ◽

MohamadHanif Hajar-Maidin ◽

Asmah Ahmad ◽

Zainora Mohammed ◽

Jamaluddin Mohamed

Keyword(s):

Young Adults ◽

Dry Eye ◽

Tear Film ◽

Kuala Lumpur ◽

Film Stability ◽

Tear Film Stability ◽

Eye Symptoms ◽

Dry Eye Symptoms

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Association among Blink Rate, Changes in Ocular Surface Temperature, Tear Film Stability, and Functional Visual Acuity in Patients after Cataract Surgery

Journal of Ophthalmology ◽

10.1155/2019/8189097 ◽

2019 ◽

Vol 2019 ◽

pp. 1-8 ◽

Cited By ~ 1

Author(s):

Takashi Itokawa ◽

Yukinobu Okajima ◽

Takashi Suzuki ◽

Tatsuhiko Kobayashi ◽

Yuto Tei ◽

...

Keyword(s):

Visual Acuity ◽

Regression Analysis ◽

Cataract Surgery ◽

Ocular Surface ◽

Tear Film ◽

Blink Rate ◽

Film Stability ◽

Tear Film Stability ◽

Functional Visual Acuity ◽

Film Group

Purpose. To investigate the association among the ocular surface temperature (OST), tear film stability, functional visual acuity (FVA), and blink rate in patients after cataract surgery. Methods. We recruited 98 eyes of 69 patients (mean age, 73.7 ± 5.2 years) 1 month after phacoemulsification with implantation of acrylic intraocular lenses and assessed slit-lamp microscopy, corrected distance VA, FVA, noninvasive tear breakup time (NIBUT), and OST. We defined the changes in the OST from 0 to 10 seconds after eye opening as the ΔOST. We measured the FVA and blink rate using the FVA measurement system. We divided the patients into two groups based on tear film stability: stable tear film (NIBUT, >5.0 seconds) and unstable tear film (NIBUT, ≤5.0 seconds). We evaluated the differences between the two groups and the association between the blink rate and other clinical parameters. Results. The unstable tear film group (56 eyes) had significantly (p<0.0001, unpaired t-test) shorter NIBUTs than the stable tear film group (42 eyes). The ΔOSTs and blink rates were significantly (p<0.0001) higher in the unstable tear film group than in the stable group. Linear single regression analysis showed that the ΔOST (r = −0.430, p<0.0001), NIBUT (r = −0.392, p<0.0001), and gender (r = −0.370, p=0.0002) were correlated significantly with the blink rate. Multiple regression analysis showed that the ΔOST independently contributed to the blink rate. Conclusions. The frequency of blinks is associated with tear film stability in patients after cataract surgery. The blink rate may be useful for evaluating the tear film stability in clinical practice. The ΔOST should be an important contributing factor to the blink rate. [This trial is registered with UMIN000026970].

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