Prevalence of high-risk human papillomavirus and abnormal pap smears in female sex workers compared to the general population in Antwerp, Belgium

Female sex workers (FSWs) have a notably high risk of acquiring human papillomavirus (HPV) infections. Relatively few studies address the type-specific prevalence and incidence of HPV among FSWs in sub-Saharan Africa. FSWs (n = 348) attending the Korogocho clinic in Nairobi, Kenya participated from August 2009 to March 2011. HPV DNA was detected using the SPF10-LiPA25 PCR assay. Baseline prevalence of HPV infection and cervical dysplasia were calculated, stratified by HIV-serostatus. Incidence rate (IR) of infection was calculated as number of new infections from baseline over person-months among 160 HPV-negative participants with complete 12-month follow-up. Baseline HPV prevalence was 23.6% for any HPV and 20.4% for high-risk HPV (hrHPV) types. Most prevalent types were HPV52 (10.1%), HPV35 (2.3%), and HPV51 (2.3%). A quarter (24%) of participants were HIV-positive. HPV prevalence was higher in HIV-positive (32.1%) than HIV-negative (20.8%) participants. hrHPV prevalence was higher in HIV-positive (27.4%) than HIV-negative (18.2%) women. During follow-up, HPV IR was 31.4 (95% CI: 23.8–41.5) for any HPV and 24.2 (95% CI: 17.9–32.8) for hrHPV types. HPV52 had the highest IR (6.0; 95% CI: 6.5–10.3). Overall HPV and hrHPV prevalence were lower than expected, but both prevalence and incidence were higher in HIV-positive than in HIV-negative women.

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Evaluation of Association between Vaginal Infections and High-Risk Human Papillomavirus Types in Female Sex Workers in Spain

ISRN Obstetrics and Gynecology ◽

10.5402/2012/240190 ◽

2012 ◽

Vol 2012 ◽

pp. 1-7 ◽

Cited By ~ 15

Author(s):

C. Rodriguez-Cerdeira ◽

E. Sanchez-Blanco ◽

A. Alba

Keyword(s):

Human Papillomavirus ◽

High Risk ◽

Bacterial Vaginosis ◽

Sex Workers ◽

Trichomonas Vaginalis ◽

Female Sex Workers ◽

Vaginal Microbiota ◽

Transmitted Infection ◽

Female Sex ◽

Associated Lesions

Background. Infection with and persistence of high-risk human papillomavirus (HR-HPV) are the strongest risk factors for cervical cancer. In addition, other genital microorganisms may also be involved in the progression of HPV-associated lesions. Objetive. To evaluate the association of the vaginal microbiota (Candida spp., Trichomonas vaginalis, and bacterial vaginosis) with HR-HPV infection in Spanish female sex workers (FSWs). Methods. This cross-sectional study involved 208 (FSWs; age, 18–49 years) who visited a sexually transmitted infection (STI) information and prevention center (SERGAS) between January 2010 and December 2011. Face-to-face interviews were carried out. Cervical and vaginal samples were examined for human papillomavirus (HPV), Trichomonas vaginalis, Candida spp., and microorganisms related to bacterial vaginosis (BV). Results. HR-HPV was found to be significantly associated with BV in FSWs with positive results for HPV16-related types (31, 33, 35, and 52). T. vaginalis was isolated in FSWs with the following HR-HPVs: 18, 45, 66, and 68. Candida spp. were isolated only in FSWs with HPV 18-positive infection. Conclusion. We demonstrate a significant prevalence of HR-HPVs in FSWs with disturbances in the vaginal microbiota.

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Higher incidence and persistence of high-risk human papillomavirus infection in female sex workers compared with women attending family planning

International Journal of Infectious Diseases ◽

10.1016/j.ijid.2011.05.011 ◽

2011 ◽

Vol 15 (10) ◽

pp. e688-e694 ◽

Cited By ~ 6

Author(s):

C. González ◽

M. Torres ◽

J. Canals ◽

E. Fernández ◽

J. Belda ◽

...

Keyword(s):

Human Papillomavirus ◽

Family Planning ◽

High Risk ◽

Sex Workers ◽

Female Sex Workers ◽

Female Sex ◽

Human Papillomavirus Infection ◽

Papillomavirus Infection

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The Role of Chlamydia trachomatis in High-Risk Human Papillomavirus Persistence Among Female Sex Workers in Nairobi, Kenya

Sexually Transmitted Diseases ◽

10.1097/olq.0000000000000287 ◽

2015 ◽

Vol 42 (6) ◽

pp. 305-311 ◽

Cited By ~ 13

Author(s):

Nadja Vielot ◽

Michael G. Hudgens ◽

Nelly Mugo ◽

Michael Chitwa ◽

Joshua Kimani ◽

...

Keyword(s):

Human Papillomavirus ◽

High Risk ◽

Chlamydia Trachomatis ◽

Sex Workers ◽

Female Sex Workers ◽

Female Sex

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Prevalence and Risk Factors of High-Risk Human Papillomavirus in Female Sex Workers in Spain: Differences by Geographical Origin

Journal of Women s Health ◽

10.1089/jwh.2008.1293 ◽

2009 ◽

Vol 18 (12) ◽

pp. 2057-2064 ◽

Cited By ~ 15

Author(s):

Julia del Amo ◽

Cristina González ◽

Josefina Belda ◽

Elisa Fernández ◽

Rosario Martínez ◽

...

Keyword(s):

Risk Factors ◽

Human Papillomavirus ◽

High Risk ◽

Sex Workers ◽

Female Sex Workers ◽

Geographical Origin ◽

Female Sex

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Hospital-based prevalence of high-risk cervical HPV types infecting the general population and female sex workers in Huzhou, China

International Journal of Gynecology & Obstetrics ◽

10.1016/j.ijgo.2012.07.019 ◽

2012 ◽

Vol 120 (1) ◽

pp. 37-41 ◽

Cited By ~ 6

Author(s):

Xiang Wang ◽

Donghua Gu ◽

Bin Lou ◽

Bin Xu ◽

Fuchu Qian ◽

...

Keyword(s):

High Risk ◽

General Population ◽

Sex Workers ◽

Female Sex Workers ◽

Female Sex ◽

Hpv Types

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High-Risk Human Papillomavirus Is Associated with HIV Acquisition among South African Female Sex Workers

Infectious Diseases in Obstetrics and Gynecology ◽

10.1155/2011/692012 ◽

2011 ◽

Vol 2011 ◽

pp. 1-9 ◽

Cited By ~ 26

Author(s):

Bertran Auvert ◽

Dianne Marais ◽

Pascale Lissouba ◽

Kevin Zarca ◽

Gita Ramjee ◽

...

Keyword(s):

Human Papillomavirus ◽

High Risk ◽

South African ◽

Sex Workers ◽

Female Sex Workers ◽

Linear Trend ◽

Hpv Infection ◽

Female Sex ◽

Hiv Seroconversion ◽

Hiv Acquisition

Background. Mounting evidence suggests an association between human papillomavirus (HPV) and HIV acquisition. This study aimed to explore this association among South African female sex workers (FSWs).Methods. We used data from 88 HIV-negative FSWs who participated in a vaginal gel (COL-1492) trial. Cervicovaginal rinse samples, obtained before HIV-seroconversion, were genotyped into high-risk (HR-) and low-risk (LR-) HPV. HIV-adjusted hazard ratios (aHRs) and 95% confidence intervals (CI) were estimated using Cox survival analysis.Results. HR- and LR-HPV prevalences were 70.5% (95% CI : 60.5–79.2) and 60.2% (95% CI : 49.9–70.0), respectively. Twenty-five women HIV seroconverted. Controlling for background characteristics and other sexually transmitted infections, HIV aHR increased by a factor of 1.7 (95% CI : 1.01–2.7,Plinear trend= 0.045) for an increase of one unit of the number of HR-HPV genotypes.Conclusions. HIV seroconversion among FSWs is associated with genital HR-HPV infection. Further investigation is warranted, including testing the possible protective effect of available HPV vaccines on HIV acquisition.

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