Clinical research: low-level laser therapy in accelerating orthodontic tooth movement

Abstract Background The present study aimed to investigate the effects of low-level laser therapy (LLLT) on orthodontic tooth movement and its correlation with the levels of interleukin-1β (IL-1β), receptor activator of nuclear factor kappa B ligand (RANKL) and osteoprotegerin (OPG) in gingival crevicular fluid (GCF). Methods This split-mouth design study included 12 patients scheduled for the extraction of both upper first premolars. Patients were randomly selected for experimental group that received left- or right-side radiation with a diode laser (810 nm wavelength, 100 mW power output, 6.29 J/cm2 energy density). Laser treatment was applied on days 0, 7, 14, and 21, after loading the canine retraction forces. GCF concentrations of IL-1β, RANKL, and OPG were analyzed. The upper arch of each patient was scanned with an intraoral scanner to assess tooth movement. Results The cumulative tooth movement over 28 days was significantly higher in the laser group than in the control group. We observed significant reductions in OPG levels and increases in IL-1β and RANKL levels in GCF samples on the experimental sides. Conclusion With the parameter settings used in this study, LLLT could, to some extent, lead to changes in bone metabolism, which could accelerate orthodontic tooth movement. Trial registration: Chinese Clinical Trial Registry, ChiCTR2000039594. Registered 2 November 2020—Retrospectively registered, www.chictr.org.cn/edit.aspx?pid=62465&htm=4.

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Low-level laser therapy increases interleukin-1β in gingival crevicular fluid and enhances the rate of orthodontic tooth movement

American Journal of Orthodontics and Dentofacial Orthopedics ◽

10.1016/j.ajodo.2019.01.004 ◽

2019 ◽

Vol 155 (4) ◽

pp. 456-457

Author(s):

Gaetano Isola ◽

Sebastiano Ferlito ◽

Ernesto Rapisarda

Keyword(s):

Laser Therapy ◽

Tooth Movement ◽

Gingival Crevicular Fluid ◽

Orthodontic Tooth Movement ◽

Interleukin 1Β ◽

Low Level Laser Therapy ◽

Low Level ◽

Low Level Laser ◽

Level Laser ◽

Crevicular Fluid

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The Effect of Low-Level Laser Therapy on the Acceleration of Orthodontic Tooth Movement

Journal of lasers in medical sciences ◽

10.34172/jlms.2020.34 ◽

2020 ◽

Vol 11 (2) ◽

pp. 204-211 ◽

Cited By ~ 1

Author(s):

Maryam Baghizadeh Fini ◽

Pooya Olyaee ◽

Ahmadreza Homayouni

Keyword(s):

Clinical Trials ◽

Laser Therapy ◽

Tooth Movement ◽

Orthodontic Tooth Movement ◽

Low Level Laser Therapy ◽

Control Group ◽

Low Level ◽

Low Level Laser ◽

Level Laser ◽

Significant Difference

In clinical practice, low-level laser therapy (LLLT) is widely used. The main aim of this review is to assess the effectiveness of LLLT in accelerating tooth movement in human subjects. The PRISMA checklist was utilized as a guideline to carry out this systematic review. The electronic databases were searched from Google Scholar (2014-2018) and PubMed, and comprehensive research on this topic was also manually conducted. Therefore, 77 articles randomized clinical trials (RCTs) or controlled clinical trials (CCTs) were selected. After screening studies, consequently, eleven trials met the inclusion criteria. Eight out of 11 studies showed LLLT has a significant impact on the acceleration of orthodontic tooth movement, and there was no statistically significant difference in the rate of tooth movement between the laser group and the control group in the two remaining studies. Furthermore, five out of 11 articles showed that LLLT has no adverse effects. Although we have some degree of understanding from a cellular point of view to LLLT effects, we still do not know whether these cellular level changes have any effect on the clinical acceleration of orthodontic tooth movement. The results are inconclusive and cannot be generalized to the public community; therefore, well-structured studies are required.

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