scholarly journals Clinical application of free-breathing 3D whole heart late gadolinium enhancement cardiovascular magnetic resonance with high isotropic spatial resolution using Compressed SENSE

2020 ◽  
Vol 22 (1) ◽  
Author(s):  
Lenhard Pennig ◽  
Simon Lennartz ◽  
Anton Wagner ◽  
Marcel Sokolowski ◽  
Matej Gajzler ◽  
...  
Keyword(s):  
Heart Rate ◽  
Cardiovascular Magnetic Resonance ◽  
Late Gadolinium Enhancement ◽  
Spatial Resolution ◽  
Free Breathing ◽  
Breath Hold ◽  
Gadolinium Enhancement ◽  
Isotropic Spatial Resolution ◽  
Scan Time ◽  
Whole Heart

Abstract Background Late gadolinium enhancement (LGE) cardiovascular magnetic resonance (CMR) represents the gold standard for assessment of myocardial viability. The purpose of this study was to investigate the clinical potential of Compressed SENSE (factor 5) accelerated free-breathing three-dimensional (3D) whole heart LGE with high isotropic spatial resolution (1.4 mm3 acquired voxel size) compared to standard breath-hold LGE imaging. Methods This was a retrospective, single-center study of 70 consecutive patients (45.8 ± 18.1 years, 27 females; February–November 2019), who were referred for assessment of left ventricular myocardial viability and received free-breathing and breath-hold LGE sequences at 1.5 T in clinical routine. Two radiologists independently evaluated global and segmental LGE in terms of localization and transmural extent. Readers scored scans regarding image quality (IQ), artifacts, and diagnostic confidence (DC) using 5-point scales (1 non-diagnostic—5 excellent/none). Effects of heart rate and body mass index (BMI) on IQ, artifacts, and DC were evaluated with ordinal logistic regression analysis. Results Global LGE (n = 33) was identical for both techniques. Using free-breathing LGE (average scan time: 04:33 ± 01:17 min), readers detected more hyperenhanced lesions (28.2% vs. 23.5%, P < .05) compared to breath-hold LGE (05:15 ± 01:23 min, P = .0104), pronounced at subepicardial localization and for 1–50% of transmural extent. For free-breathing LGE, readers graded scans with good/excellent IQ in 80.0%, with low-impact/no artifacts in 78.6%, and with good/high DC in 82.1% of cases. Elevated BMI was associated with increased artifacts (P = .0012) and decreased IQ (P = .0237). Increased heart rate negatively influenced artifacts (P = .0013) and DC (P = .0479) whereas IQ (P = .3025) was unimpaired. Conclusions In a clinical setting, free-breathing Compressed SENSE accelerated 3D high isotropic spatial resolution whole heart LGE provides good to excellent image quality in 80% of scans independent of heart rate while enabling improved depiction of small and particularly non-ischemic hyperenhanced lesions in a shorter scan time than standard breath-hold LGE.

scholarly journals Motion-corrected free-breathing late gadolinium enhancement combined with a gadolinium contrast agent with a high relaxation rate: an optimized cardiovascular magnetic resonance examination protocol

2020 ◽  
Vol 48 (10) ◽  
pp. 030006052096466
Author(s):  
Cui Yan ◽  
Junjiao Hu ◽  
Yanyu Li ◽  
Xingzhi Xie ◽  
Zhimin Zou ◽  
...  
Keyword(s):  
Cardiovascular Magnetic Resonance ◽  
Late Gadolinium Enhancement ◽  
Magnetic Resonance ◽  
Contrast Agent ◽  
Relaxation Rate ◽  
Gadolinium Enhancement ◽  
Gadolinium Contrast ◽  
Gadolinium Contrast Agent ◽  
Examination Protocol ◽  
Scan Time

Objective This prospective study investigated the feasibility of an optimized cardiovascular magnetic resonance (CMR) examination protocol using the motion-corrected (MOCO), balanced steady-state free precession (bSSFP), phase-sensitive inversion recovery (PSIR) sequence combined with a gadolinium contrast agent with a high relaxation rate in patients who cannot hold their breath. Methods Fifty-one patients with heart disease underwent CMR examinations twice and these were performed with different late gadolinium enhancement (LGE) imaging sequences (fast low-angle shot [FLASH] sequence vs. MOCO sequence) and different gadolinium contrast agents (gadopentetate dimeglumine vs. gadobenate dimeglumine) with a 48-hour interval. LGE image quality, total time spent in the whole study, and time taken to perform LGE imaging were compared for the two CMR examinations. Results LGE images with the MOCO bSSFP PSIR sequence showed significantly higher image quality compared with those with the segmented FLASH PSIR sequence. There was a significant difference between the total scan time for the two examinations and different LGE sequences. Conclusions The MOCO bSSFP PSIR sequence effectively improves the quality of LGE images. Changing the CMR scanning protocol by combining the MOCO bSSFP PSIR sequence with a gadolinium contrast agent with a high relaxation rate effectively shortens the scan time. Clinical trial registration number: ChiCTR-ROC-17013978.

scholarly journals Free-breathing late gadolinium enhancement CMR with a fixed short scan time using CosMo

2012 ◽  
Vol 14 (S1) ◽  
Author(s):  
Mehdi H Moghari ◽  
Hussein Rayatzadeh ◽  
Susie Hong ◽  
Raymond H Chan ◽  
Mehmet Akcakaya ◽  
...  
Keyword(s):  
Late Gadolinium Enhancement ◽  
Free Breathing ◽  
Gadolinium Enhancement ◽  
Scan Time

scholarly journals 3D whole-heart grey-blood late gadolinium enhancement cardiovascular magnetic resonance imaging

2021 ◽  
Vol 23 (1) ◽  
Author(s):  
Giorgia Milotta ◽  
Camila Munoz ◽  
Karl P. Kunze ◽  
Radhouene Neji ◽  
Stefano Figliozzi ◽  
...  
Keyword(s):  
Late Gadolinium Enhancement ◽  
Image Quality ◽  
Free Breathing ◽  
Inversion Recovery ◽  
Water Volume ◽  
Gadolinium Enhancement ◽  
Isotropic Resolution ◽  
Whole Heart ◽  
2D And 3D ◽  
Dual Echo

Abstract Purpose To develop a free-breathing whole-heart isotropic-resolution 3D late gadolinium enhancement (LGE) sequence with Dixon-encoding, which provides co-registered 3D grey-blood phase-sensitive inversion-recovery (PSIR) and complementary 3D fat volumes in a single scan of < 7 min. Methods A free-breathing 3D PSIR LGE sequence with dual-echo Dixon readout with a variable density Cartesian trajectory with acceleration factor of 3 is proposed. Image navigators are acquired to correct both inversion recovery (IR)-prepared and reference volumes for 2D translational respiratory motion, enabling motion compensated PSIR reconstruction with 100% respiratory scan efficiency. An intermediate PSIR reconstruction is performed between the in-phase echoes to estimate the signal polarity which is subsequently applied to the IR-prepared water volume to generate a water grey-blood PSIR image. The IR-prepared water volume is obtained using a water/fat separation algorithm from the corresponding dual-echo readout. The complementary fat-volume is obtained after water/fat separation of the reference volume. Ten patients (6 with myocardial scar) were scanned with the proposed water/fat grey-blood 3D PSIR LGE sequence at 1.5 T and compared to breath-held grey-blood 2D LGE sequence in terms of contrast ratio (CR), contrast-to-noise ratio (CNR), scar depiction, scar transmurality, scar mass and image quality. Results Comparable CRs (p = 0.98, 0.40 and 0.83) and CNRs (p = 0.29, 0.40 and 0.26) for blood-myocardium, scar-myocardium and scar-blood respectively were obtained with the proposed free-breathing 3D water/fat LGE and 2D clinical LGE scan. Excellent agreement for scar detection, scar transmurality, scar mass (bias = 0.29%) and image quality scores (from 1: non-diagnostic to 4: excellent) of 3.8 ± 0.42 and 3.6 ± 0.69 (p > 0.99) were obtained with the 2D and 3D PSIR LGE approaches with comparable total acquisition time (p = 0.29). Similar agreement in intra and inter-observer variability were obtained for the 2D and 3D acquisition respectively. Conclusion The proposed approach enabled the acquisition of free-breathing motion-compensated isotropic-resolution 3D grey-blood PSIR LGE and fat volumes. The proposed approach showed good agreement with conventional 2D LGE in terms of CR, scar depiction and scan time, while enabling free-breathing acquisition, whole-heart coverage, reformatting in arbitrary views and visualization of both water and fat information.

scholarly journals Accelerated Late Gadolinium Enhancement Cardiac MR Imaging with Isotropic Spatial Resolution Using Compressed Sensing: Initial Experience

Radiology ◽  
2012 ◽  
Vol 264 (3) ◽  
pp. 691-699 ◽  
Author(s):  
Mehmet Akçakaya ◽  
Hussein Rayatzadeh ◽  
Tamer A. Basha ◽  
Susie N. Hong ◽  
Raymond H. Chan ◽  
...  
Keyword(s):  
Late Gadolinium Enhancement ◽  
Mr Imaging ◽  
Compressed Sensing ◽  
Spatial Resolution ◽  
Initial Experience ◽  
Gadolinium Enhancement ◽  
Cardiac Mr ◽  
Isotropic Spatial Resolution
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