scholarly journals Clinicopathological features of idiopathic membranous nephropathy combined with IgA nephropathy: a retrospective analysis of 9 cases

2016 ◽  
Vol 11 (1) ◽  
Author(s):  
Ruimin Hu ◽  
Guolan Xing ◽  
Huijuan Wu ◽  
Zhigang Zhang
Keyword(s):  
Retrospective Analysis ◽  
Iga Nephropathy ◽  
Membranous Nephropathy ◽  
Clinicopathological Features ◽  
Idiopathic Membranous Nephropathy

scholarly journals The correlation between Serum phospholipase A2 receptor antibody and clinicopathological features in patients with membranous nephropathy

2021 ◽  
Vol 5 (2.1) ◽  
pp. 8
Author(s):  
Qipeng Huang ◽  
Gaosi Xu ◽  
Fang Wang ◽  
Fang Zeng ◽  
Weidong Fang
Keyword(s):  
Phospholipase A2 ◽  
Membranous Nephropathy ◽  
Clinicopathological Features ◽  
Stage I ◽  
Stage Ii ◽  
Stage Iii ◽  
Idiopathic Membranous Nephropathy ◽  
Receptor Antibody ◽  
Phospholipase A2 Receptor ◽  
Normal Controls

Objective: To assess the correlation between Serum phospholipase A2 receptor antibody and clinicopathological features in patients with membranous nephropathy. Method: The patients being hospitalized for renal biopsy were selected in this study from January 2016 to January 2018. And normal controls were randomly selected; all the patients were divided into idiopathic membranous nephropathy and non-idiopathic membranous nephropathy groups; patients with idiopathic membranous nephropathy were divided into three groups, namely stage I, stage II and stage III; using software for statistical analysis. Results: A total of 357 patients were enrolled, including 155 patients with idiopathic membranous nephropathy, 183 patients with non-idiopathic membranous nephropathy, and 19 cases for normal controls. The average age of the idiopathic membranous nephropathy (IMN) group is higher than that of the membranous nephropathy group (P = 0.01). Different pathological stages of idiopathic membranous nephropathy general clinical characteristics analysis results showed that the age, cys c, serum creatinine (Scr) in stage III membranous nephropathy group were higher than those of the stage I and II membranous nephropathy (P values were 0.003, 0.000 and 0.000 respectively); titers of serum phospholipase A2 receptors antibody with stage II and III membranous nephropathy higher than the stage I membranous nephropathy group (P = 0.006); serum albumin (Alb) levels correlated inversely with serum anti-PLA2R antibody titers (rs = –0.234, P = 0.003), serum antiphospholipase A2 receptor (PLA2R) antibody titer level in patients with idiopathic membranous nephropathy was significantly higher than that in patients with non-membranous nephropathy (P < 0.001). Conclusion: Baseline titer of serum anti-PLA2R antibody is negatively correlated with Alb in the IMN patients，and serum anti-PLA2R antibody level in patients with stage I IMN was significantly lower than stage II and III IMN patients.

scholarly journals P0128COMPARISON OF ULTRASTRUCTURE FEATURES BETWEEN PATIENTS WITH MERCURY-ASSOCIATED MEMBRANOUS NEPHROPATHY AND IDIOPATHIC MEMBRANOUS NEPHROPATHY

2020 ◽  
Vol 35 (Supplement_3) ◽  
Author(s):  
Aibo Qin ◽  
Zishan Lin ◽  
Fude Zhou ◽  
Minghui Zhao ◽  
Suxia Wang ◽  
...  
Keyword(s):  
Membranous Nephropathy ◽  
Prolonged Exposure ◽  
High Sensitivity ◽  
Clinicopathological Features ◽  
Idiopathic Membranous Nephropathy ◽  
Dense Deposits ◽  
Foot Process ◽  
The Difference ◽  
Potential Tool ◽  
Glomerular Capillaries

Abstract Background and Aims Prolonged exposure to mercury can cause membranous nephropathy. The routine clinicopathological features of mercury-associated membranous nephropathy (M-MN) and idiopathic membranous nephropathy (I-MN) are similar. The difference in ultrastructure between them was observed clinically. The current study retrospectively compared the ultrastructure features, clinical and pathological data, treatment and prognosis of patients with M-MN and I-MN. Method Thirteen patients with M-MN and 13 patients with I-MN were enrolled. The clinical and pathological data were retrospectively collected. Electron micrographs of glomerular capillaries were taken and the foot process width (FPW) and the number of foot processes per 10 μm glomerular basement membrane (GBM) were measured. The presence and location of electron-dense deposits in mesangium and subendothelial region were recorded. Results Patients with M-MN were younger (38.7±8.5 versus 45.8±5.7 years, P=0.020), with a shorter duration of complete remission (9.0±6.1 versus 20.3±9.8 months, P=0.004) and lower relapse rate (0% versus 45.5%, P=0.014) than patients with I-MN. As to ultrastructure, patients with M-MN had lower levels of FPW [974.3nm (range 791.2∼1504.4) versus 2370.6nm (range 2219.4∼2559.1), P=0.001, Figure 1], more foot processes per 10 μm GBM [8.1 (range 5.2∼10.0) versus 3.3 (range 3.1∼3.5), P=0.001], and higher ratio of mesangial electron-dense deposits (41.7% versus 0, P=0.015, Figure 2) than those with I-MN. Multivariate analysis showed that type of disease (M-MN or I-MN) and stage of MN (stageIor stageIIand above) were the two only determinants of FPW. FPW over 1645 nm differentiated M-MN from I-MN with high sensitivity (92.3%) and specificity (83.3%). Conclusion The quantitative analysis of foot processes may offer a potential tool to distinguish M-MN from I-MN. Better prognosis in patients with M-MN may be related to minor podocyte damage.

scholarly journals Risk alleles for IgA nephropathy-associated SNPs conferred completely opposite effects to idiopathic membranous nephropathy in Chinese Han

2017 ◽  
Vol 65 (5) ◽  
pp. 1059-1064 ◽  
Author(s):  
Xiaosong Qin ◽  
Chen Wang ◽  
Guanting Lu ◽  
Mengle Peng ◽  
Guixue Cheng ◽  
...  
Keyword(s):  
Iga Nephropathy ◽  
Membranous Nephropathy ◽  
Idiopathic Membranous Nephropathy ◽  
Chinese Han ◽  
Risk Alleles

scholarly journals A rare case of PLA2R- and THSD7A-positive idiopathic membranous nephropathy

2020 ◽  
Vol 42 (2) ◽  
pp. 254-258
Author(s):  
David Campos Wanderley ◽  
Bárbara Dornelas Jones ◽  
Fabricio Augusto Marques Barbosa ◽  
Stanley de Almeida Araujo
Keyword(s):  
Nephrotic Syndrome ◽  
Iga Nephropathy ◽  
Male Patient ◽  
Membranous Nephropathy ◽  
Rare Case ◽  
The Other ◽  
Idiopathic Membranous Nephropathy ◽  
Secondary Literature ◽  
Nephrotic Range Proteinuria ◽  
Histopathology Examination

ABSTRACT Idiopathic membranous nephropathy (IMN) is a frequent cause of nephrotic syndrome in adults. In terms of etiology, the condition may be categorized as primary/idiopathic or secondary. Literature on the pathophysiology of IMN has indicated the presence of autoantibodies (PLA2R and THSD7A) directed against podocyte antigens. The detection of antibodies against a domain favors IMN. The presence of autoantibodies against one of the domains would in theory exclude the possibility of there being autoantibodies against the other domain. However, cases of patients with PLA2R- and THSD7A-positive disease have been recently reported, showing that antibodies against two targets may be concomitantly produced via yet unknown pathophysiological mechanisms. This study reports the case of a 46-year-old male patient with nephrotic-range proteinuria, hematuria, hypoalbuminemia, and hypercholesterolemia submitted to biopsy and histopathology examination (LM, IF, IHC, and EM) eventually diagnosed with PLA2R- and THSD7A-positive IMN associated with IgA nephropathy, stressing our experience with the use of IgG subclasses, PLA2R, and THSD7A in the workup for MN and the relevance of adopting a broad and adequate approach to elucidating and acquiring knowledge of the pathophysiology of IMN.

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